Claudin-1-Dependent Destabilization of the Blood–Brain Barrier in Chronic Stroke

• Published in: The Journal of neuroscience Vol. 39; no. 4; pp. 743 - 757
• Main Authors: Sladojevic, Nikola, Stamatovic, Svetlana M., Johnson, Allison M., Choi, Jennifer, Hu, Anna, Dithmer, Sophie, Blasig, Ingolf E., Keep, Richard F., Andjelkovic, Anuska V.
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 23.01.2019
• Subjects: Animals; Barriers; Blood vessels; Blood-brain barrier; Blood-Brain Barrier - pathology; Brain; Brain Ischemia - pathology; Cell membranes; Claudin-1 - genetics; Claudin-5 - biosynthesis; Claudin-5 - genetics; Dementia disorders; Destabilization; Down-Regulation - genetics; Endothelial cells; Endothelial Cells - pathology; Energy recovery; Energy transfer; Female; Fluorescence; Fluorescence recovery after photobleaching; Fluorescence resonance energy transfer; Health risks; Humans; Infarction, Middle Cerebral Artery - genetics; Infarction, Middle Cerebral Artery - pathology; Inflammation; Inflammation - pathology; Leakage; Male; Mice; Morphology; mRNA; Permeability; Phenotypes; Photobleaching; Proteins; Recovery of function; Stroke; Stroke - genetics; Stroke - pathology; Substrates; Tight Junctions - pathology; Vascular dementia; Zonula occludens-1 protein; Zonula Occludens-1 Protein - biosynthesis; Zonula Occludens-1 Protein - genetics; cerebrovascular injury; claudin-1; BBB recovery; stroke

Recent evidence suggests that blood–brain barrier (BBB) recovery and reestablishment of BBB impermeability after stroke is incomplete. This could influence stroke recovery, increase the risk of repeat stroke, and be a solid substrate for developing vascular dementia. Although accumulating evidence h...