Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

• Published in: Nature communications Vol. 6; no. 1; p. 6656
• Main Authors: Pillai, Vinodkumar B., Samant, Sadhana, Sundaresan, Nagalingam R., Raghuraman, Hariharasundaram, Kim, Gene, Bonner, Michael Y., Arbiser, Jack L., Walker, Douglas I., Jones, Dean P., Gius, David, Gupta, Mahesh P.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.04.2015; Nature Publishing Group
• Subjects: 13; 13/2; 13/31; 38; 38/109; 38/77; 42; 631/154/349; 631/443/592/1540; 631/92/612/100/2285; 631/92/612/1240; 96; 96/106; 96/95; Acetylation - drug effects; Adenosine Triphosphatases - antagonists & inhibitors; Adenosine Triphosphatases - genetics; Adenosine Triphosphatases - metabolism; Animals; Biphenyl Compounds - pharmacology; Cardiomegaly - chemically induced; Cardiomegaly - genetics; Cardiomegaly - pathology; Cardiomegaly - prevention & control; Cardiotonic Agents - pharmacology; Carrier Proteins - antagonists & inhibitors; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Differentiation - drug effects; Cell Proliferation - drug effects; Enzyme Activation; Fibroblasts - drug effects; Fibroblasts - enzymology; Fibroblasts - pathology; Gene Expression Regulation; Humanities and Social Sciences; Isoproterenol; Lignans - pharmacology; Membrane Proteins - antagonists & inhibitors; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mitochondria - drug effects; Mitochondria - enzymology; Mitochondria - pathology; multidisciplinary; Myocardium - enzymology; Myocardium - pathology; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - enzymology; Myocytes, Cardiac - pathology; Myofibroblasts - drug effects; Myofibroblasts - enzymology; Myofibroblasts - pathology; Phenylephrine - pharmacology; Primary Cell Culture; Reactive Oxygen Species - antagonists & inhibitors; Reactive Oxygen Species - metabolism; Science; Science (multidisciplinary); Signal Transduction; Sirtuin 3 - genetics; Sirtuin 3 - metabolism; Superoxide Dismutase - antagonists & inhibitors; Superoxide Dismutase - genetics; Superoxide Dismutase - metabolism

Honokiol (HKL) is a natural biphenolic compound derived from the bark of magnolia trees with anti-inflammatory, anti-oxidative, anti-tumour and neuroprotective properties. Here we show that HKL blocks agonist-induced and pressure overload-mediated, cardiac hypertrophic responses, and ameliorates pre...