Diagnosis- and Cell Type-Specific Mitochondrial Functional Pathway Signatures in Schizophrenia and Bipolar Disorder

• Published in: The American journal of psychiatry Vol. 177; no. 12; pp. 1140 - 1150
• Main Authors: Glausier, Jill R., Enwright, John F., Lewis, David A.
• Format: Journal Article
• Language: English
• Published: United States American Psychiatric Association 01.12.2020
• Subjects: Animals; Antipsychotic Agents - pharmacology; Antipsychotics; Bipolar disorder; Bipolar Disorder - genetics; Cerebral Cortex - metabolism; Down-Regulation; Female; Gene expression; Gene Expression - drug effects; Gene Expression Profiling - statistics & numerical data; Gray Matter - metabolism; Humans; Macaca fuscata; Macaca mulatta; Male; Medical diagnosis; Mitochondria; Mitochondria - metabolism; Prefrontal Cortex - metabolism; Psychosis; Pyramidal Cells - metabolism; Schizophrenia; Schizophrenia - genetics; Signal Transduction - genetics; Schizophrenia; Genetics; Bipolar Disorder; Mitochondrial Function

The shared risk factors and clinical features in schizophrenia and bipolar disorder may be linked via mitochondrial dysfunction. However, the severity of mitochondrial dysfunction, and/or the specific mitochondrial functional pathways affected, may differ between diagnoses, especially at the level o...