A Calcium-Based Simple Model of Multiple Spike Interactions in Spike-Timing-Dependent Plasticity

• Published in: Neural computation Vol. 25; no. 7; pp. 1853 - 1869
• Main Authors: Uramoto, Takumi, Torikai, Hiroyuki
• Format: Journal Article
• Language: English
• Published: One Rogers Street, Cambridge, MA 02142-1209, USA MIT Press 01.07.2013; MIT Press Journals, The
• Subjects: Action Potentials - physiology; Animals; Brain; Brain - cytology; Calcium; Calcium - metabolism; Comparative analysis; In Vitro Techniques; Letters; Models, Neurological; Neuronal Plasticity - physiology; Neurons - physiology; Ordinary differential equations; Sensory perception; Synapses - physiology
• ISSN: 0899-7667; 1530-888X
• DOI: 10.1162/NECO_a_00462

Spike-timing-dependent plasticity (STDP) is a form of synaptic modification that depends on the relative timings of presynaptic and postsynaptic spikes. In this letter, we proposed a calcium-based simple STDP model, described by an ordinary differential equation having only three state variables: one represents the density of intracellular calcium, one represents a fraction of open state NMDARs, and one represents the synaptic weight. We shown that in spite of its simplicity, the model can reproduce the properties of the plasticity that have been experimentally measured in various brain areas (e.g., layer 2/3 and 5 visual cortical slices, hippocampal cultures, and layer 2/3 somatosensory cortical slices) with respect to various patterns of presynaptic and postsynaptic spikes. In addition, comparisons with other STDP models are made, and the significance and advantages of the proposed model are discussed.