Development and characterization of a microfluidic model of the tumour microenvironment

• Published in: Scientific reports Vol. 6; no. 1; p. 36086
• Main Authors: Ayuso, Jose M., Virumbrales-Muñoz, María, Lacueva, Alodia, Lanuza, Pilar M., Checa-Chavarria, Elisa, Botella, Pablo, Fernández, Eduardo, Doblare, Manuel, Allison, Simon J., Phillips, Roger M., Pardo, Julián, Fernandez, Luis J., Ochoa, Ignacio
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 31.10.2016; Nature Publishing Group
• Subjects: 13/109; 13/2; 13/62; 14/34; 631/1647/277; 631/67/327; 631/67/70; Apoptosis; Cancer; Cell interactions; Cell proliferation; Chemotherapy; Data processing; Drug screening; Glucose; Humanities and Social Sciences; Microfluidics; multidisciplinary; Nutrients; Oxygen; Physiology; Science; Spheroids; Tumor microenvironment; Tumors

The physical microenvironment of tumours is characterized by heterotypic cell interactions and physiological gradients of nutrients, waste products and oxygen. This tumour microenvironment has a major impact on the biology of cancer cells and their response to chemotherapeutic agents. Despite this,...