Resistin Promotes Cardiac Hypertrophy via the AMP-activated Protein Kinase/Mammalian Target of Rapamycin (AMPK/mTOR) and c-Jun N-terminal Kinase/Insulin Receptor Substrate 1 (JNK/IRS1) Pathways

• Published in: The Journal of biological chemistry Vol. 286; no. 21; pp. 18465 - 18473
• Main Authors: Kang, Soojeong, Chemaly, Elie R., Hajjar, Roger J., Lebeche, Djamel
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.05.2011; American Society for Biochemistry and Molecular Biology
• Subjects: AMP-activated Kinase (AMPK); AMP-Activated Protein Kinases - antagonists & inhibitors; AMP-Activated Protein Kinases - genetics; AMP-Activated Protein Kinases - metabolism; Animals; Apoptosis - drug effects; Apoptosis - genetics; Biomarkers - metabolism; Cardiac Hypertrophy; Cardiomegaly - genetics; Cardiomegaly - metabolism; Cardiomegaly - pathology; Cardiomyocyte; Cells, Cultured; Diabetes; Diabetic Cardiomyopathy; Enzyme Inhibitors - pharmacology; Gene Expression Regulation - drug effects; Gene Expression Regulation - genetics; Gene Transfer; Insulin Receptor Substrate Proteins - antagonists & inhibitors; Insulin Receptor Substrate Proteins - genetics; Insulin Receptor Substrate Proteins - metabolism; Insulin Resistance; Insulin Resistance - genetics; JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors; JNK Mitogen-Activated Protein Kinases - genetics; JNK Mitogen-Activated Protein Kinases - metabolism; Molecular Bases of Disease; mTOR, JNK Signaling; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Natriuretic Peptide, Brain - biosynthesis; Natriuretic Peptide, Brain - genetics; Phosphorylation - drug effects; Phosphorylation - genetics; Rats; Rats, Sprague-Dawley; Resistin; Resistin - genetics; Resistin - metabolism; Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors; Ribosomal Protein S6 Kinases, 70-kDa - genetics; Ribosomal Protein S6 Kinases, 70-kDa - metabolism; Signal Transduction; TOR Serine-Threonine Kinases - antagonists & inhibitors; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Ventricular Myosins - biosynthesis; Ventricular Myosins - genetics; Cardiomyocyte; Insulin Resistance; AMP-activated Kinase (AMPK); Gene Transfer; Diabetes; mTOR, JNK Signaling; Cardiac Hypertrophy; Diabetic Cardiomyopathy; Resistin

Resistin has been suggested to be involved in the development of diabetes and insulin resistance. We recently reported that resistin is expressed in diabetic hearts and promotes cardiac hypertrophy; however, the mechanisms underlying this process are currently unknown. Therefore, we wanted to elucid...