Low magnesium in conjunction with high homocysteine increases DNA damage in healthy middle aged Australians

• Published in: European journal of nutrition Vol. 63; no. 7; pp. 2555 - 2565
• Main Authors: Dhillon, Varinderpal S., Deo, Permal, Fenech, Michael
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2024; Springer Nature B.V
• Subjects: Adult; Australasian People; biomarkers; Biomarkers - blood; blood; Blood levels; Chemistry; Chemistry and Materials Science; Cytokinesis; DNA biosynthesis; DNA damage; DNA Damage - drug effects; DNA repair; DNA replication; Female; Folic acid; Folic Acid - blood; Homocysteine; Homocysteine - blood; Humans; Lymphocytes; Lymphocytes - drug effects; Lymphocytes - metabolism; Magnesium; Magnesium - blood; Magnesium Deficiency - blood; Male; metabolism; Micronuclei; Micronucleus Tests - methods; Middle age; Middle Aged; Nutrition; Original Contribution; Peripheral blood; risk; South Australia; Vitamin B 12 - blood; Vitamin B12; South Australia; Nuclear buds (NBuds); DNA damage; Nucleoplasmic bridges (NPBs); Magnesium; Cytokinesis-block Micronucleus Cytome; Homocysteine; Micronuclei (MN)

Purpose Magnesium is one of the most common elements in the human body and plays an important role as a cofactor of enzymes required for DNA replication and repair and many other biochemical mechanisms including sensing and regulating one-carbon metabolism deficiencies. Low intake of magnesium can i...