Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen

• Published in: The Journal of biological chemistry Vol. 284; no. 16; pp. 10552 - 10560
• Main Authors: Hishiki, Asami, Hashimoto, Hiroshi, Hanafusa, Tomo, Kamei, Keijiro, Ohashi, Eiji, Shimizu, Toshiyuki, Ohmori, Haruo, Sato, Mamoru
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 17.04.2009; American Society for Biochemistry and Molecular Biology
• Subjects: Amino Acid Sequence; Animals; Crystallography, X-Ray; DNA Damage; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase - chemistry; DNA-Directed DNA Polymerase - genetics; DNA-Directed DNA Polymerase - metabolism; Humans; Isoenzymes - chemistry; Isoenzymes - genetics; Isoenzymes - metabolism; Molecular Sequence Data; Proliferating Cell Nuclear Antigen - chemistry; Proliferating Cell Nuclear Antigen - genetics; Proliferating Cell Nuclear Antigen - metabolism; Protein Binding; Protein Conformation; Sequence Alignment

Translesion synthesis (TLS) is a DNA damage tolerance mechanism that allows continued DNA synthesis, even in the presence of damaged DNA templates. Mammals have multiple DNA polymerases specialized for TLS, including Polη, Polι, and Polκ. These enzymes show preferential bypass for different lesions....