Division and Adaptation to Host Environment of Apicomplexan Parasites Depend on Apicoplast Lipid Metabolic Plasticity and Host Organelle Remodeling

• Published in: Cell reports (Cambridge) Vol. 30; no. 11; pp. 3778 - 3792.e9
• Main Authors: Amiar, Souad, Katris, Nicholas J., Berry, Laurence, Dass, Sheena, Duley, Samuel, Arnold, Christophe-Sebastien, Shears, Melanie J., Brunet, Camille, Touquet, Bastien, McFadden, Geoffrey I., Yamaryo-Botté, Yoshiki, Botté, Cyrille Y.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 17.03.2020; Elsevier
• Subjects: Acyltransferases - metabolism; Adaptation, Physiological; Animals; Apicomplexa; apicoplast; Apicoplasts - metabolism; Biochemistry, Molecular Biology; Cancer; Cell Division; Cell Membrane - metabolism; Cellular Biology; Cytokinesis; Fatty Acid Synthases - metabolism; Fatty Acids - biosynthesis; Gene Deletion; host nutritional environment; host-parasite interaction; Host-Parasite Interactions; Human health and pathology; Humans; Infectious diseases; Intracellular Space - parasitology; Life Cycle Stages; Life Sciences; Lipid Metabolism; lipid synthesis; Lipidomics; malaria; Male; Microbiology and Parasitology; Models, Biological; Multivesicular Bodies - metabolism; Multivesicular Bodies - ultrastructure; Mutation - genetics; Nutrients; Parasites - growth & development; Parasites - metabolism; Parasites - physiology; Parasites - ultrastructure; Parasitology; phosphatidic acid; Protozoan Proteins - metabolism; Quantitative Methods; Toxoplasma - growth & development; Toxoplasma - metabolism; Toxoplasma - physiology; Toxoplasma - ultrastructure; toxoplasmosis; Vegetal Biology; Apicomplexa; lipid synthesis; host nutritional environment; toxoplasmosis; cytokinesis; host-parasite interaction; phosphatidic acid; malaria; lipidomics; apicoplast

Apicomplexan parasites are unicellular eukaryotic pathogens that must obtain and combine lipids from both host cell scavenging and de novo synthesis to maintain parasite propagation and survival within their human host. Major questions on the role and regulation of each lipid source upon fluctuating...