High frequency of kidney and urinary tract anomalies in asymptomatic first-degree relatives of patients with CAKUT

• Published in: Pediatric nephrology (Berlin, West) Vol. 28; no. 11; pp. 2143 - 2147
• Main Authors: Bulum, Burcu, Özçakar, Z. Birsin, Üstüner, Evren, Düşünceli, Ebru, Kavaz, Aslı, Duman, Duygu, Walz, Katherina, Fitoz, Suat, Tekin, Mustafa, Yalçınkaya, Fatoş
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2013; Springer; Springer Nature B.V
• Subjects: Adolescent; Asymptomatic; Birth defects; Child; Child, Preschool; Cluster Analysis; Congenital diseases; Diagnosis; Familial diseases; Families & family life; Family; Female; Genetic aspects; Humans; Infant; Kidney - abnormalities; Kidney - diagnostic imaging; Kidney diseases; Male; Medicine; Medicine & Public Health; Mutation; Nephrology; Original Article; Parents; Pathogenesis; Patients; Pediatrics; Siblings; Turkey - epidemiology; Ultrasonic imaging; Ultrasonography; Urinary Tract - abnormalities; Urinary Tract - diagnostic imaging; Urinary tract diseases; Urogenital Abnormalities; Urogenital system; Urologic diseases; Urologic Diseases - genetics; Urology; Vesico-Ureteral Reflux - genetics; Vesico-Ureteral Reflux - pathology; Young Adult; Turkey; Ankara Turkey; CAKUT; First-degree relatives; Kidney and urinary tract anomalies; Familial clustering; Renal ultrasound

Background Congenital anomalies of the kidney and urinary tract (CAKUT) commonly cause chronic kidney disease in children. While most CAKUT cases are sporadic, observed familial clustering suggests that the pathogenesis is influenced by genetic factors. Methods The purpose of the present study is to...