Tocilizumab for Severe Worsening COVID-19 Pneumonia: a Propensity Score Analysis

• Published in: Journal of clinical immunology Vol. 41; no. 2; pp. 303 - 314
• Main Authors: Roumier, Mathilde, Paule, Romain, Vallée, Alexandre, Rohmer, Julien, Ballester, Marie, Brun, Anne-Laure, Cerf, Charles, Chabi, Marie-Laure, Chinet, Thierry, Colombier, Marie-Alice, Farfour, Eric, Fourn, Erwan, Géri, Guillaume, Khau, David, Marroun, Ibrahim, Ponsoye, Matthieu, Roux, Antoine, Salvator, Hélène, Schoindre, Yoland, Si Larbi, Anne-Gaëlle, Tchérakian, Colas, Vasse, Marc, Verrat, Anne, Zuber, Benjamin, Couderc, Louis-Jean, Kahn, Jean-Emmanuel, Groh, Matthieu, Ackermann, Félix
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2021; Springer Nature B.V; Springer Verlag
• Subjects: Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized - administration & dosage; Antibodies, Monoclonal, Humanized - adverse effects; Antibodies, Monoclonal, Humanized - therapeutic use; Biomedical and Life Sciences; Biomedicine; C-reactive protein; Clinical trials; Combined Modality Therapy; Coronaviruses; COVID-19; COVID-19 - diagnosis; COVID-19 - virology; COVID-19 Drug Treatment; Disease Progression; Female; Fibrinogen; Humans; Immunology; Immunosuppressive agents; Infectious Diseases; Inflammation; Interleukin 6; Interleukin 6 receptors; Internal Medicine; Intravenous administration; Kaplan-Meier Estimate; Life Sciences; Male; Mechanical ventilation; Medical Microbiology; Middle Aged; Monoclonal antibodies; Neutropenia; Original; Original Article; Oxygen; Oxygen therapy; Patients; Pneumonia; Propensity Score; Receptors, Interleukin-6 - antagonists & inhibitors; SARS-CoV-2 - drug effects; Severity of Illness Index; Treatment Outcome; COVID-19; tocilizumab; intensive care unit; cytokine storm; interleukin-6

Background High levels of serum interleukin-6 (IL-6) correlate with disease severity in COVID-19. We hypothesized that tocilizumab (a recombinant humanized anti-IL-6 receptor) could improve outcomes in selected patients with severe worsening COVID-19 pneumonia and high inflammatory parameters. Metho...