Imaging of Intact Tissue Sections: Moving beyond the Microscope

• Published in: The Journal of biological chemistry Vol. 286; no. 29; pp. 25459 - 25466
• Main Authors: Seeley, Erin H., Schwamborn, Kristina, Caprioli, Richard M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.07.2011; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Drugs; Humans; Imaging Mass Spectrometry; Lipids; Mass Spectrometry (MS); Metabolites; Minireviews; Molecular Imaging - methods; Peptides; Peptides - metabolism; Pharmaceutical Preparations - metabolism; Proteins; Proteins - metabolism; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods; Tissue; Drugs; Proteins; Tissue; Peptides; Metabolites; Proteomics; Mass Spectrometry (MS); Imaging Mass Spectrometry; Lipids

MALDI-imaging MS is a new molecular imaging technology for direct in situ analysis of thin tissue sections. Multiple analytes can be monitored simultaneously without prior knowledge of their identities and without the need for target-specific reagents such as antibodies. Imaging MS provides importan...