Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to Enhance CHOP Translation

• Published in: The Journal of biological chemistry Vol. 286; no. 13; pp. 10939 - 10949
• Main Authors: Palam, Lakshmi Reddy, Baird, Thomas D., Wek, Ronald C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2011; American Society for Biochemistry and Molecular Biology
• Subjects: Activating Transcription Factor 4 - genetics; Activating Transcription Factor 4 - metabolism; Animals; Apoptosis - physiology; Cell Line; ER Stress; Eukaryotic Initiation Factor-2 - genetics; Eukaryotic Initiation Factor-2 - metabolism; Mice; Open Reading Frames - physiology; Phosphorylation - physiology; Protein Biosynthesis - physiology; Protein Synthesis; Protein Synthesis and Degradation; Ribosomes - genetics; Ribosomes - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Stress, Physiological - physiology; Transcription Factor CHOP - biosynthesis; Transcription Factor CHOP - genetics; Translation; Translation Control; Translation Regulation; Translation; Protein Synthesis; ER Stress; Translation Regulation; Translation Control

In response to different environmental stresses, phosphorylation of eukaryotic initiation factor-2 (eIF2) rapidly reduces protein synthesis, which lowers energy expenditure and facilitates reprogramming of gene expression to remediate stress damage. Central to the changes in gene expression, eIF2 ph...