SENP2 regulates mitochondrial function and insulin secretion in pancreatic β cells

• Published in: Experimental & molecular medicine Vol. 54; no. 1; pp. 72 - 80
• Main Authors: Nan, Jinyan, Lee, Ji Seon, Moon, Joon Ho, Lee, Seung-Ah, Park, Young Joo, Lee, Dong-Sup, Chung, Sung Soo, Park, Kyong Soo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2022; Springer Nature B.V; 생화학분자생물학회
• Subjects: 14/28; 42/109; 42/70; 631/337/458/1733; 631/80/304; 631/80/458/538; 64/110; 64/60; 692/163/2743/137; 82/29; 82/51; 82/80; Adipogenesis; Animals; Beta cells; Biomedical and Life Sciences; Biomedicine; Cell culture; Cysteine Endopeptidases - genetics; Cysteine Endopeptidases - metabolism; Diabetes; Diabetes mellitus (non-insulin dependent); Glucose; Glucose - metabolism; Glucose tolerance; Insulin; Insulin - metabolism; Insulin Secretion; Insulin-Secreting Cells - metabolism; Investigations; Lipid metabolism; Medical Biochemistry; Metabolism; Mice; Mitochondria; Mitochondria - metabolism; Mitochondrial Proteins - metabolism; Molecular Medicine; Oxygen consumption; Palmitic acid; Pancreas; Peptide Hydrolases - metabolism; Phosphorylation; Protein turnover; Proteins; Secretion; Skeletal muscle; Stem Cells; Ubiquitin; 생화학

Increasing evidence has shown that small ubiquitin-like modifier (SUMO) modification plays an important role in metabolic regulation. We previously demonstrated that SUMO-specific protease 2 (SENP2) is involved in lipid metabolism in skeletal muscle and adipogenesis. In this study, we investigated t...