Ambient atmospheric PM worsens mouse lung injury induced by influenza A virus through lysosomal dysfunction

• Published in: Respiratory research Vol. 24; no. 1; pp. 306 - 12
• Main Authors: Li, Shunwang, Ju, Xiangwu, Liu, Qiang, Yan, Yiwu, Zhang, Cong, Qin, Yuhao, Deng, Xingyu, Li, Chang, Tian, Mingyao, Zhang, Yanli, Jin, Ningyi, Jiang, Chengyu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.12.2023; BioMed Central; BMC
• Subjects: Air pollution; Aluminum Oxide; Alveoli; Animals; Antibodies; Avian flu; Care and treatment; Cell death; Cloning; Complications and side effects; Degradation; Environmental aspects; Epithelial cells; Epithelium; Experiments; Health aspects; Humans; Infections; Influenza; Influenza A; Influenza A virus; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H5N1 Subtype; Influenza, Human; Laboratory animals; Lamps; Life cycles; Lung injury; Lung Injury - chemically induced; Lungs; Lysosomes; Membrane proteins; Membranes; Metabolism, Inborn errors of; Mice; Mortality; Nanoparticles; Orthomyxoviridae; Outdoor air quality; Particles; Particulate emissions; Particulate matter; Prevention; Proteins; Respiratory diseases; Risk factors; Silica; Silicon Dioxide; siRNA; Synergistic effect; Viruses; China; Beijing China; United States > US; Particulate matter; Influenza a virus; Lung injury

Particulate matter (PM) air pollution poses a significant risk to respiratory health and is especially linked with various infectious respiratory diseases such as influenza. Our previous studies have shown that H5N1 virus infection could induce alveolar epithelial A549 cell death by enhancing lysoso...