Induction of HIV-1–Specific Mucosal Immune Responses Following Intramuscular Recombinant Adenovirus Serotype 26 HIV-1 Vaccination of Humans

• Published in: The Journal of infectious diseases Vol. 211; no. 4; pp. 518 - 528
• Main Authors: Baden, Lindsey R., Liu, Jinyan, Li, Hualin, Johnson, Jennifer A., Walsh, Stephen R., Kleinjan, Jane A., Engelson, Brian A., Peter, Lauren, Abbink, Peter, Milner, Danny A., Golden, Kevin L., Viani, Kyle L., Stachler, Matthew D., Chen, Benjamin J., Pau, Maria G., Weijtens, Mo, Carey, Brittany R., Miller, Caroline A., Swann, Edith M., Wolff, Mark, Loblein, Hayley, Seaman, Michael S., Dolin, Raphael, Barouch, Dan H.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 15.02.2015
• Subjects: Adenovirus; Adenoviruses, Human - immunology; Adult; AIDS Vaccines - administration & dosage; AIDS Vaccines - adverse effects; AIDS Vaccines - immunology; CD4-Positive T-Lymphocytes - immunology; Colon - immunology; Colon - pathology; Cytokines - blood; env Gene Products, Human Immunodeficiency Virus - immunology; Enzyme-Linked Immunosorbent Assay; Female; HIV Antibodies - blood; HIV Antibodies - immunology; HIV Infections - prevention & control; HIV-1 - immunology; HIV/AIDS; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; Immunity, Mucosal - immunology; Injections, Intramuscular; Intestinal Mucosa - immunology; Intestinal Mucosa - pathology; Major and Brief Reports; Male; Middle Aged; Young Adult; vaccine; HIV; adenovirus; mucosal immunity

Background. Defining mucosal immune responses and inflammation to candidate human immunodeficiency virus type 1 (HIV-1) vaccines represents a current research priority for the HIV-1 vaccine field. In particular, it is unclear whether intramuscular immunization can elicit immune responses at mucosal...