Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue

The genetic regulation of the human epigenome is not fully appreciated. Here we describe the effects of genetic variants on the DNA methylome in human lung based on methylation-quantitative trait loci (meQTL) analyses. We report 34,304 cis - and 585 trans -meQTLs, a genetic–epigenetic interaction of...

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Published inNature communications Vol. 5; no. 1; p. 3365
Main Authors Shi, Jianxin, Marconett, Crystal N., Duan, Jubao, Hyland, Paula L., Li, Peng, Wang, Zhaoming, Wheeler, William, Zhou, Beiyun, Campan, Mihaela, Lee, Diane S., Huang, Jing, Zhou, Weiyin, Triche, Tim, Amundadottir, Laufey, Warner, Andrew, Hutchinson, Amy, Chen, Po-Han, Chung, Brian S. I., Pesatori, Angela C., Consonni, Dario, Bertazzi, Pier Alberto, Bergen, Andrew W., Freedman, Mathew, Siegmund, Kimberly D., Berman, Benjamin P., Borok, Zea, Chatterjee, Nilanjan, Tucker, Margaret A., Caporaso, Neil E., Chanock, Stephen J., Laird-Offringa, Ite A., Landi, Maria Teresa
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 27.02.2014
Nature Publishing Group
Subjects
631/208/2489/2487/2486
631/208/726/649
631/67/1612
Breast - metabolism
Carcinogenesis
CpG Islands - genetics
DNA Methylation
Epistasis, Genetic
Gene mapping
Genetic diversity
Genetic Predisposition to Disease - ethnology
Genetic Predisposition to Disease - genetics
Genetic variance
Genetic Variation
Genome-Wide Association Study
Genotype
Health risks
Humanities and Social Sciences
Humans
Hypersensitivity
Kidney - metabolism
Lung - metabolism
Lung cancer
Lung Neoplasms - ethnology
Lung Neoplasms - genetics
multidisciplinary
Polymorphism, Single Nucleotide
Promoter Regions, Genetic - genetics
Quantitative Trait Loci - genetics
Risk Factors
Science
Science (multidisciplinary)
White People - genetics
Online AccessGet full text

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Abstract The genetic regulation of the human epigenome is not fully appreciated. Here we describe the effects of genetic variants on the DNA methylome in human lung based on methylation-quantitative trait loci (meQTL) analyses. We report 34,304 cis - and 585 trans -meQTLs, a genetic–epigenetic interaction of surprising magnitude, including a regulatory hotspot. These findings are replicated in both breast and kidney tissues and show distinct patterns: cis -meQTLs mostly localize to CpG sites outside of genes, promoters and CpG islands (CGIs), while trans -meQTLs are over-represented in promoter CGIs. meQTL SNPs are enriched in CTCF-binding sites, DNaseI hypersensitivity regions and histone marks. Importantly, four of the five established lung cancer risk loci in European ancestry are cis- meQTLs and, in aggregate, cis -meQTLs are enriched for lung cancer risk in a genome-wide analysis of 11,587 subjects. Thus, inherited genetic variation may affect lung carcinogenesis by regulating the human methylome. The effects of genetic variation on DNA methylation patterns are poorly understood. Here, Shi et al. systematically map methylation-quantitative trait loci in lung, breast and kidney tissue to reveal the impact of inherited variation on the human methylome, which also affects cancer risk.
AbstractList The genetic regulation of the human epigenome is not fully appreciated. Here we describe the effects of genetic variants on the DNA methylome in human lung based on methylation-quantitative trait loci (meQTL) analyses. We report 34,304 cis- and 585 trans-meQTLs, a genetic-epigenetic interaction of surprising magnitude, including a regulatory hotspot. These findings are replicated in both breast and kidney tissues and show distinct patterns: cis-meQTLs mostly localize to CpG sites outside of genes, promoters and CpG islands (CGIs), while trans-meQTLs are over-represented in promoter CGIs. meQTL SNPs are enriched in CTCF-binding sites, DNaseI hypersensitivity regions and histone marks. Importantly, four of the five established lung cancer risk loci in European ancestry are cis-meQTLs and, in aggregate, cis-meQTLs are enriched for lung cancer risk in a genome-wide analysis of 11,587 subjects. Thus, inherited genetic variation may affect lung carcinogenesis by regulating the human methylome.The genetic regulation of the human epigenome is not fully appreciated. Here we describe the effects of genetic variants on the DNA methylome in human lung based on methylation-quantitative trait loci (meQTL) analyses. We report 34,304 cis- and 585 trans-meQTLs, a genetic-epigenetic interaction of surprising magnitude, including a regulatory hotspot. These findings are replicated in both breast and kidney tissues and show distinct patterns: cis-meQTLs mostly localize to CpG sites outside of genes, promoters and CpG islands (CGIs), while trans-meQTLs are over-represented in promoter CGIs. meQTL SNPs are enriched in CTCF-binding sites, DNaseI hypersensitivity regions and histone marks. Importantly, four of the five established lung cancer risk loci in European ancestry are cis-meQTLs and, in aggregate, cis-meQTLs are enriched for lung cancer risk in a genome-wide analysis of 11,587 subjects. Thus, inherited genetic variation may affect lung carcinogenesis by regulating the human methylome.
The genetic regulation of the human epigenome is not fully appreciated. Here we describe the effects of genetic variants on the DNA methylome in human lung based on methylation-quantitative trait loci (meQTL) analyses. We report 34,304 cis- and 585 trans-meQTLs, a genetic-epigenetic interaction of surprising magnitude, including a regulatory hotspot. These findings are replicated in both breast and kidney tissues and show distinct patterns: cis-meQTLs mostly localize to CpG sites outside of genes, promoters and CpG islands (CGIs), while trans-meQTLs are over-represented in promoter CGIs. meQTL SNPs are enriched in CTCF-binding sites, DNaseI hypersensitivity regions and histone marks. Importantly, four of the five established lung cancer risk loci in European ancestry are cis-meQTLs and, in aggregate, cis-meQTLs are enriched for lung cancer risk in a genome-wide analysis of 11,587 subjects. Thus, inherited genetic variation may affect lung carcinogenesis by regulating the human methylome.
The genetic regulation of the human epigenome is not fully appreciated. Here we describe the effects of genetic variants on the DNA methylome in human lung based on methylation-quantitative trait loci (meQTL) analyses. We report 34,304 cis - and 585 trans -meQTLs, a genetic-epigenetic interaction of surprising magnitude, including a regulatory hotspot. These findings are replicated in both breast and kidney tissues and show distinct patterns: cis -meQTLs mostly localize to CpG sites outside of genes, promoters, and CpG islands (CGIs), while trans -meQTLs are over-represented in promoter CGIs. meQTL SNPs are enriched in CTCF binding sites, DNaseI hypersensitivity regions and histone marks. Importantly, 4 of the 5 established lung cancer risk loci in European ancestry are cis- meQTLs and, in aggregate, cis -meQTLs are enriched for lung cancer risk in a genome-wide analysis of 11,587 subjects. Thus, inherited genetic variation may affect lung carcinogenesis by regulating the human methylome.
The genetic regulation of the human epigenome is not fully appreciated. Here we describe the effects of genetic variants on the DNA methylome in human lung based on methylation-quantitative trait loci (meQTL) analyses. We report 34,304 cis - and 585 trans -meQTLs, a genetic–epigenetic interaction of surprising magnitude, including a regulatory hotspot. These findings are replicated in both breast and kidney tissues and show distinct patterns: cis -meQTLs mostly localize to CpG sites outside of genes, promoters and CpG islands (CGIs), while trans -meQTLs are over-represented in promoter CGIs. meQTL SNPs are enriched in CTCF-binding sites, DNaseI hypersensitivity regions and histone marks. Importantly, four of the five established lung cancer risk loci in European ancestry are cis- meQTLs and, in aggregate, cis -meQTLs are enriched for lung cancer risk in a genome-wide analysis of 11,587 subjects. Thus, inherited genetic variation may affect lung carcinogenesis by regulating the human methylome. The effects of genetic variation on DNA methylation patterns are poorly understood. Here, Shi et al. systematically map methylation-quantitative trait loci in lung, breast and kidney tissue to reveal the impact of inherited variation on the human methylome, which also affects cancer risk.
ArticleNumber 3365
Author Zhou, Beiyun
Duan, Jubao
Zhou, Weiyin
Pesatori, Angela C.
Shi, Jianxin
Wheeler, William
Chen, Po-Han
Laird-Offringa, Ite A.
Hyland, Paula L.
Chanock, Stephen J.
Bertazzi, Pier Alberto
Hutchinson, Amy
Consonni, Dario
Li, Peng
Berman, Benjamin P.
Tucker, Margaret A.
Chung, Brian S. I.
Borok, Zea
Freedman, Mathew
Campan, Mihaela
Amundadottir, Laufey
Lee, Diane S.
Triche, Tim
Landi, Maria Teresa
Warner, Andrew
Siegmund, Kimberly D.
Caporaso, Neil E.
Chatterjee, Nilanjan
Huang, Jing
Marconett, Crystal N.
Wang, Zhaoming
Bergen, Andrew W.
AuthorAffiliation 8 Bioinformatics Division, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089, USA
7 Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
10 Unit of Epidemiology, IRCCS Fondazione Ca’ Granda Ospedale Maggiore Policlinico and Department of Clinical Sciences and Community Health, University of Milan, Milan, 20122, Italy
3 Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90089, USA
9 Pathology/Histotechnology Laboratory, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, 21702, USA
13 Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215
4 Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, North Shore University Health System Research Ins
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/24572595$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/nature09386
10.1038/nrg2969
10.1016/S0168-9525(97)01181-5
10.1101/gr.136101.111
10.1002/ijc.27870
10.1038/ng.286
10.1038/sj.emboj.7600509
10.1158/2159-8290.CD-11-0246
10.1038/nrg3230
10.1093/hmg/ddm010
10.1016/j.ajhg.2010.02.005
10.1038/ng.298
10.1016/S0092-8674(00)81967-4
10.1101/gr.101907.109
10.1038/nature08629
10.1214/10-AOAS400
10.1093/molbev/msj115
10.1074/jbc.M112.382416
10.1371/journal.pgen.1002956
10.1038/ng.857
10.1038/nature09165
10.1371/journal.pgen.1000529
10.1371/journal.pgen.1003513
10.1038/nature06846
10.1016/j.ajhg.2009.09.012
10.1038/ng.840
10.1038/ng.254
10.1038/ng1011-1040c
10.1371/journal.pgen.1000952
10.1038/nature06885
10.1186/gb-2012-13-10-r84
10.1038/ng.2394
10.1093/nar/gkm875
10.1038/ng.109
10.1038/ng.2205
10.1186/1471-2458-8-203
10.1093/nar/gkt090
10.1371/journal.pone.0055923
10.1186/gb-2012-13-1-r7
10.1186/gb-2011-12-1-r10
10.1016/j.molcel.2013.02.010
10.1038/nrg3345
10.1074/jbc.M001538200
10.1038/nature12477
10.1016/j.cell.2009.06.001
10.1126/science.1222794
10.1111/j.0006-341X.1999.00997.x
10.1093/hmg/dds334
10.1101/cshperspect.a001008
10.1038/nature10442
10.1016/j.cell.2013.03.008
10.1126/science.1697983
10.1093/carcin/bgt062
10.1038/ng.273
10.1186/gb-2003-4-5-p3
10.1371/journal.pgen.1003486
10.1016/j.ajhg.2013.10.004
10.1038/nature11232
10.1371/journal.pbio.1001046
10.1038/nature09534
10.1038/nature07385
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References Landi (CR19) 2008; 8
Landi (CR20) 2009; 85
Irizarry (CR13) 2009; 41
Fairfax (CR40) 2012; 44
Shen, Laird (CR12) 2013; 153
Thurman (CR28) 2012; 489
Dennis (CR23) 2003; 4
Tekpli (CR37) 2013; 132
Siegmund, Yakir, Zhang (CR62) 2011; 5
Grundberg (CR6) 2013; 93
Thorgeirsson (CR32) 2008; 452
Grundberg (CR50) 2012; 44
Phillips, Corces (CR55) 2009; 137
Freedman (CR46) 2011; 43
Drong (CR5) 2013; 8
Maunakea (CR9) 2010; 466
Small (CR41) 2011; 43
Montgomery, Dermitzakis (CR15) 2011; 12
Zhang (CR4) 2010; 86
Howie, Donnelly, Marchini (CR59) 2009; 5
Heinig (CR42) 2010; 467
Yoder, Walsh, Bestor (CR10) 1997; 13
Amos (CR30) 2008; 40
Marconett (CR29) 2013; 9
Shi (CR35) 2012; 2
Wang (CR27) 2012; 22
Bao, Zhou, Cui (CR64) 2008; 36
Shukla (CR39) 2011; 479
Timofeeva (CR36) 2012; 21
McKay (CR34) 2008; 40
Papamichos-Chronakis, Peterson (CR52) 2013; 14
Bell (CR7) 2011; 12
Falvella (CR38) 2013; 34
Handoko (CR54) 2011; 43
Kaminsky (CR1) 2009; 41
Korostowski, Sedlak, Engel (CR44) 2012; 8
CR17
Devlin, Roeder (CR61) 1999; 55
Wu (CR43) 2012; 287
Jones (CR21) 2012; 13
Alexandrov (CR14) 2013; 500
Sabin, Delas, Hannon (CR45) 2013; 49
Chernukhin (CR53) 2000; 275
Gaffney (CR25) 2012; 13
Maurano (CR24) 2012; 337
Sproul (CR49) 2012; 13
Jones (CR18) 2012; 13
Brenner (CR57) 2005; 24
Bell, West, Felsenfeld (CR56) 1999; 98
Triche, Weisenberger, Van Den Berg, Laird, Siegmund (CR58) 2013; 41
Pleasance (CR48) 2010; 463
Heijmans, Kremer, Tobi, Boomsma, Slagboom (CR2) 2007; 16
Flutre, Wen, Pritchard, Stephens (CR51) 2013; 9
CR26
Gibbs (CR3) 2010; 6
Kim, Yi (CR63) 2006; 23
CR22
CR60
Wang (CR33) 2008; 40
Olivier, Hollstein, Hainaut (CR47) 2010; 2
Laurent (CR8) 2010; 20
Rideout, Coetzee, Olumi, Jones (CR11) 1990; 249
Schiller, Lucas, Ward, Peregoy (CR16) 2012; 10
Hung (CR31) 2008; 452
J Shi (BFncomms4365_CR35) 2012; 2
BFncomms4365_CR60
PA Jones (BFncomms4365_CR21) 2012; 13
BT Heijmans (BFncomms4365_CR2) 2007; 16
LR Sabin (BFncomms4365_CR45) 2013; 49
M Papamichos-Chronakis (BFncomms4365_CR52) 2013; 14
ZA Kaminsky (BFncomms4365_CR1) 2009; 41
CI Amos (BFncomms4365_CR30) 2008; 40
MT Landi (BFncomms4365_CR20) 2009; 85
S Shukla (BFncomms4365_CR39) 2011; 479
L Korostowski (BFncomms4365_CR44) 2012; 8
Y Wu (BFncomms4365_CR43) 2012; 287
MT Maurano (BFncomms4365_CR24) 2012; 337
MN Timofeeva (BFncomms4365_CR36) 2012; 21
T Flutre (BFncomms4365_CR51) 2013; 9
BFncomms4365_CR22
BFncomms4365_CR26
TE Thorgeirsson (BFncomms4365_CR32) 2008; 452
C Brenner (BFncomms4365_CR57) 2005; 24
KS Small (BFncomms4365_CR41) 2011; 43
AC Bell (BFncomms4365_CR56) 1999; 98
L Laurent (BFncomms4365_CR8) 2010; 20
TJ Triche Jr (BFncomms4365_CR58) 2013; 41
E Grundberg (BFncomms4365_CR6) 2013; 93
PA Jones (BFncomms4365_CR18) 2012; 13
BFncomms4365_CR17
DJ Gaffney (BFncomms4365_CR25) 2012; 13
L Bao (BFncomms4365_CR64) 2008; 36
Y Wang (BFncomms4365_CR33) 2008; 40
RE Thurman (BFncomms4365_CR28) 2012; 489
FS Falvella (BFncomms4365_CR38) 2013; 34
B Devlin (BFncomms4365_CR61) 1999; 55
JT Bell (BFncomms4365_CR7) 2011; 12
RJ Hung (BFncomms4365_CR31) 2008; 452
AK Maunakea (BFncomms4365_CR9) 2010; 466
BN Howie (BFncomms4365_CR59) 2009; 5
MT Landi (BFncomms4365_CR19) 2008; 8
G Dennis Jr (BFncomms4365_CR23) 2003; 4
X Tekpli (BFncomms4365_CR37) 2013; 132
ED Pleasance (BFncomms4365_CR48) 2010; 463
D Sproul (BFncomms4365_CR49) 2012; 13
CN Marconett (BFncomms4365_CR29) 2013; 9
H Shen (BFncomms4365_CR12) 2013; 153
JE Phillips (BFncomms4365_CR55) 2009; 137
JD McKay (BFncomms4365_CR34) 2008; 40
H Wang (BFncomms4365_CR27) 2012; 22
JA Yoder (BFncomms4365_CR10) 1997; 13
E Grundberg (BFncomms4365_CR50) 2012; 44
M Heinig (BFncomms4365_CR42) 2010; 467
IV Chernukhin (BFncomms4365_CR53) 2000; 275
RA Irizarry (BFncomms4365_CR13) 2009; 41
M Olivier (BFncomms4365_CR47) 2010; 2
BP Fairfax (BFncomms4365_CR40) 2012; 44
WM Rideout (BFncomms4365_CR11) 1990; 249
SH Kim (BFncomms4365_CR63) 2006; 23
JR Gibbs (BFncomms4365_CR3) 2010; 6
D Siegmund (BFncomms4365_CR62) 2011; 5
L Handoko (BFncomms4365_CR54) 2011; 43
JS Schiller (BFncomms4365_CR16) 2012; 10
D Zhang (BFncomms4365_CR4) 2010; 86
LB Alexandrov (BFncomms4365_CR14) 2013; 500
SB Montgomery (BFncomms4365_CR15) 2011; 12
ML Freedman (BFncomms4365_CR46) 2011; 43
AW Drong (BFncomms4365_CR5) 2013; 8
References_xml – ident: CR22
– volume: 467
  start-page: 460
  year: 2010
  end-page: 464
  ident: CR42
  article-title: A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
  publication-title: Nature
  doi: 10.1038/nature09386
– volume: 12
  start-page: 277
  year: 2011
  end-page: 282
  ident: CR15
  article-title: From expression QTLs to personalized transcriptomics
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg2969
– volume: 10
  start-page: 1
  year: 2012
  end-page: 207
  ident: CR16
  article-title: Summary health statistics for U.S. adults: National Health Interview Survey, 2010
  publication-title: Vital. Health. Stat.
– volume: 13
  start-page: 335
  year: 1997
  end-page: 340
  ident: CR10
  article-title: Cytosine methylation and the ecology of intragenomic parasites
  publication-title: Trends Genet.
  doi: 10.1016/S0168-9525(97)01181-5
– volume: 22
  start-page: 1680
  year: 2012
  end-page: 1688
  ident: CR27
  article-title: Widespread plasticity in CTCF occupancy linked to DNA methylation
  publication-title: Genome Res.
  doi: 10.1101/gr.136101.111
– volume: 132
  start-page: 1811
  year: 2013
  end-page: 1820
  ident: CR37
  article-title: Functional effect of polymorphisms in 15q25 locus on CHRNA5 mRNA, bulky DNA adducts and TP53 mutations
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.27870
– volume: 41
  start-page: 240
  year: 2009
  end-page: 245
  ident: CR1
  article-title: DNA methylation profiles in monozygotic and dizygotic twins
  publication-title: Nat. Genet.
  doi: 10.1038/ng.286
– volume: 24
  start-page: 336
  year: 2005
  end-page: 346
  ident: CR57
  article-title: Myc represses transcription through recruitment of DNA methyltransferase corepressor
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7600509
– volume: 2
  start-page: 131
  year: 2012
  end-page: 139
  ident: CR35
  article-title: Inherited variation at chromosome 12p13.33, including RAD52, influences the risk of squamous cell lung carcinoma
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-11-0246
– volume: 13
  start-page: 484
  year: 2012
  end-page: 492
  ident: CR18
  article-title: Functions of DNA methylation: islands, start sites, gene bodies and beyond
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg3230
– volume: 16
  start-page: 547
  year: 2007
  end-page: 554
  ident: CR2
  article-title: Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddm010
– volume: 86
  start-page: 411
  year: 2010
  end-page: 419
  ident: CR4
  article-title: Genetic control of individual differences in gene-specific methylation in human brain
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2010.02.005
– volume: 41
  start-page: 178
  year: 2009
  end-page: 186
  ident: CR13
  article-title: The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
  publication-title: Nat. Genet.
  doi: 10.1038/ng.298
– volume: 98
  start-page: 387
  year: 1999
  end-page: 396
  ident: CR56
  article-title: The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81967-4
– volume: 20
  start-page: 320
  year: 2010
  end-page: 331
  ident: CR8
  article-title: Dynamic changes in the human methylome during differentiation
  publication-title: Genome Res.
  doi: 10.1101/gr.101907.109
– volume: 463
  start-page: 184
  year: 2010
  end-page: 190
  ident: CR48
  article-title: A small-cell lung cancer genome with complex signatures of tobacco exposure
  publication-title: Nature
  doi: 10.1038/nature08629
– volume: 5
  start-page: 24
  year: 2011
  ident: CR62
  article-title: Detecting simultaneous variant intervals in aligned sequences
  publication-title: Ann. Appl. Stat.
  doi: 10.1214/10-AOAS400
– volume: 23
  start-page: 1068
  year: 2006
  end-page: 1075
  ident: CR63
  article-title: Correlated asymmetry of sequence and functional divergence between duplicate proteins of saccharomyces cerevisiae
  publication-title: Mol. Biol. Evol.
  doi: 10.1093/molbev/msj115
– volume: 287
  start-page: 40003
  year: 2012
  end-page: 40011
  ident: CR43
  article-title: Interplay between menin and K-Ras in regulating lung adenocarcinoma
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.382416
– volume: 8
  start-page: e1002956
  year: 2012
  ident: CR44
  article-title: The Kcnq1ot1 long non-coding RNA affects chromatin conformation and expression of Kcnq1, but does not regulate its imprinting in the developing heart
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1002956
– volume: 43
  start-page: 630
  year: 2011
  end-page: 638
  ident: CR54
  article-title: CTCF-mediated functional chromatin interactome in pluripotent cells
  publication-title: Nat. Genet.
  doi: 10.1038/ng.857
– volume: 466
  start-page: 253
  year: 2010
  end-page: 257
  ident: CR9
  article-title: Conserved role of intragenic DNA methylation in regulating alternative promoters
  publication-title: Nature
  doi: 10.1038/nature09165
– volume: 5
  start-page: e1000529
  year: 2009
  ident: CR59
  article-title: A flexible and accurate genotype imputation method for the next generation of genome-wide association studies
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1000529
– volume: 13
  start-page: 484
  year: 2012
  end-page: 492
  ident: CR21
  article-title: Functions of DNA methylation: islands, start sites, gene bodies and beyond
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg3230
– volume: 9
  start-page: e1003513
  year: 2013
  ident: CR29
  article-title: Integrated transcriptomic and epigenomic analysis reveals novel pathways regulating distal lung epithelial cell differentiation
  publication-title: Plos Genet.
  doi: 10.1371/journal.pgen.1003513
– volume: 452
  start-page: 638
  year: 2008
  end-page: 642
  ident: CR32
  article-title: A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
  publication-title: Nature
  doi: 10.1038/nature06846
– ident: CR60
– volume: 85
  start-page: 679
  year: 2009
  end-page: 691
  ident: CR20
  article-title: A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2009.09.012
– volume: 43
  start-page: 513
  year: 2011
  end-page: 518
  ident: CR46
  article-title: Principles for the post-GWAS functional characterization of cancer risk loci
  publication-title: Nat. Genet.
  doi: 10.1038/ng.840
– volume: 40
  start-page: 1404
  year: 2008
  end-page: 1406
  ident: CR34
  article-title: Lung cancer susceptibility locus at 5p15.33
  publication-title: Nat. Genet.
  doi: 10.1038/ng.254
– volume: 43
  start-page: 561
  year: 2011
  end-page: 564
  ident: CR41
  article-title: Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes
  publication-title: Nat. Genet.
  doi: 10.1038/ng1011-1040c
– ident: CR26
– volume: 6
  start-page: e1000952
  year: 2010
  ident: CR3
  article-title: Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1000952
– volume: 452
  start-page: 633
  year: 2008
  end-page: 637
  ident: CR31
  article-title: A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
  publication-title: Nature
  doi: 10.1038/nature06885
– volume: 13
  start-page: R84
  year: 2012
  ident: CR49
  article-title: Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns
  publication-title: Genome Biol.
  doi: 10.1186/gb-2012-13-10-r84
– volume: 44
  start-page: 1084
  year: 2012
  end-page: 1089
  ident: CR50
  article-title: Mapping cis- and trans-regulatory effects across multiple tissues in twins
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2394
– volume: 36
  start-page: D83
  year: 2008
  end-page: D87
  ident: CR64
  article-title: CTCFBSDB: a CTCF-binding site database for characterization of vertebrate genomic insulators
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkm875
– volume: 40
  start-page: 616
  year: 2008
  end-page: 622
  ident: CR30
  article-title: Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
  publication-title: Nat. Genet.
  doi: 10.1038/ng.109
– volume: 44
  start-page: 502
  year: 2012
  end-page: 510
  ident: CR40
  article-title: Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2205
– volume: 8
  start-page: 203
  year: 2008
  ident: CR19
  article-title: Environment And Genetics in Lung cancer Etiology (EAGLE) study: an integrative population-based case-control study of lung cancer
  publication-title: BMC Public Health
  doi: 10.1186/1471-2458-8-203
– volume: 41
  start-page: e90
  year: 2013
  ident: CR58
  article-title: Low-level processing of Illumina Infinium DNA Methylation BeadArrays
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt090
– volume: 8
  start-page: e55923
  year: 2013
  ident: CR5
  article-title: The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0055923
– volume: 13
  start-page: R7
  year: 2012
  ident: CR25
  article-title: Dissecting the regulatory architecture of gene expression QTLs
  publication-title: Genome Biol.
  doi: 10.1186/gb-2012-13-1-r7
– volume: 12
  start-page: R10
  year: 2011
  ident: CR7
  article-title: DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines
  publication-title: Genome Biol.
  doi: 10.1186/gb-2011-12-1-r10
– volume: 49
  start-page: 783
  year: 2013
  end-page: 794
  ident: CR45
  article-title: Dogma derailed: the many influences of RNA on the genome
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2013.02.010
– volume: 14
  start-page: 62
  year: 2013
  end-page: 75
  ident: CR52
  article-title: Chromatin and the genome integrity network
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg3345
– volume: 275
  start-page: 29915
  year: 2000
  end-page: 29921
  ident: CR53
  article-title: Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M001538200
– volume: 500
  start-page: 415
  year: 2013
  end-page: 421
  ident: CR14
  article-title: Signatures of mutational processes in human cancer
  publication-title: Nature
  doi: 10.1038/nature12477
– volume: 137
  start-page: 1194
  year: 2009
  end-page: 1211
  ident: CR55
  article-title: CTCF: master weaver of the genome
  publication-title: Cell
  doi: 10.1016/j.cell.2009.06.001
– volume: 337
  start-page: 1190
  year: 2012
  end-page: 1195
  ident: CR24
  article-title: Systematic localization of common disease-associated variation in regulatory DNA
  publication-title: Science
  doi: 10.1126/science.1222794
– volume: 55
  start-page: 997
  year: 1999
  end-page: 1004
  ident: CR61
  article-title: Genomic control for association studies
  publication-title: Biometrics
  doi: 10.1111/j.0006-341X.1999.00997.x
– volume: 21
  start-page: 4980
  year: 2012
  end-page: 4995
  ident: CR36
  article-title: Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/dds334
– volume: 2
  start-page: a001008
  year: 2010
  ident: CR47
  article-title: TP53 mutations in human cancers: origins, consequences, and clinical use
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a001008
– ident: CR17
– volume: 479
  start-page: 74
  year: 2011
  end-page: 79
  ident: CR39
  article-title: CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing
  publication-title: Nature
  doi: 10.1038/nature10442
– volume: 153
  start-page: 38
  year: 2013
  end-page: 55
  ident: CR12
  article-title: Interplay between the cancer genome and epigenome
  publication-title: Cell
  doi: 10.1016/j.cell.2013.03.008
– volume: 249
  start-page: 1288
  year: 1990
  end-page: 1290
  ident: CR11
  article-title: 5-Methylcytosine as an endogenous mutagen in the human Ldl receptor and P53 Genes
  publication-title: Science
  doi: 10.1126/science.1697983
– volume: 34
  start-page: 1281
  year: 2013
  end-page: 1285
  ident: CR38
  article-title: Multiple isoforms and differential allelic expression of CHRNA5 in lung tissue and lung adenocarcinoma
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgt062
– volume: 40
  start-page: 1407
  year: 2008
  end-page: 1409
  ident: CR33
  article-title: Common 5p15.33 and 6p21.33 variants influence lung cancer risk
  publication-title: Nat. Genet.
  doi: 10.1038/ng.273
– volume: 4
  start-page: P3
  year: 2003
  ident: CR23
  article-title: DAVID: Database for Annotation, Visualization, and Integrated Discovery
  publication-title: Genome Biol.
  doi: 10.1186/gb-2003-4-5-p3
– volume: 9
  start-page: e1003486
  year: 2013
  ident: CR51
  article-title: A statistical framework for joint eQTL analysis in multiple tissues
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1003486
– volume: 93
  start-page: 876
  year: 2013
  end-page: 890
  ident: CR6
  article-title: Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2013.10.004
– volume: 489
  start-page: 75
  year: 2012
  end-page: 82
  ident: CR28
  article-title: The accessible chromatin landscape of the human genome
  publication-title: Nature
  doi: 10.1038/nature11232
– volume: 8
  start-page: e55923
  year: 2013
  ident: BFncomms4365_CR5
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0055923
– volume: 86
  start-page: 411
  year: 2010
  ident: BFncomms4365_CR4
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2010.02.005
– volume: 34
  start-page: 1281
  year: 2013
  ident: BFncomms4365_CR38
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgt062
– volume: 463
  start-page: 184
  year: 2010
  ident: BFncomms4365_CR48
  publication-title: Nature
  doi: 10.1038/nature08629
– volume: 40
  start-page: 616
  year: 2008
  ident: BFncomms4365_CR30
  publication-title: Nat. Genet.
  doi: 10.1038/ng.109
– volume: 249
  start-page: 1288
  year: 1990
  ident: BFncomms4365_CR11
  publication-title: Science
  doi: 10.1126/science.1697983
– volume: 41
  start-page: e90
  year: 2013
  ident: BFncomms4365_CR58
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt090
– volume: 452
  start-page: 633
  year: 2008
  ident: BFncomms4365_CR31
  publication-title: Nature
  doi: 10.1038/nature06885
– volume: 43
  start-page: 561
  year: 2011
  ident: BFncomms4365_CR41
  publication-title: Nat. Genet.
  doi: 10.1038/ng1011-1040c
– volume: 44
  start-page: 1084
  year: 2012
  ident: BFncomms4365_CR50
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2394
– volume: 9
  start-page: e1003513
  year: 2013
  ident: BFncomms4365_CR29
  publication-title: Plos Genet.
  doi: 10.1371/journal.pgen.1003513
– volume: 13
  start-page: 335
  year: 1997
  ident: BFncomms4365_CR10
  publication-title: Trends Genet.
  doi: 10.1016/S0168-9525(97)01181-5
– volume: 467
  start-page: 460
  year: 2010
  ident: BFncomms4365_CR42
  publication-title: Nature
  doi: 10.1038/nature09386
– volume: 9
  start-page: e1003486
  year: 2013
  ident: BFncomms4365_CR51
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1003486
– volume: 23
  start-page: 1068
  year: 2006
  ident: BFncomms4365_CR63
  publication-title: Mol. Biol. Evol.
  doi: 10.1093/molbev/msj115
– volume: 49
  start-page: 783
  year: 2013
  ident: BFncomms4365_CR45
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2013.02.010
– volume: 2
  start-page: 131
  year: 2012
  ident: BFncomms4365_CR35
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-11-0246
– volume: 13
  start-page: 484
  year: 2012
  ident: BFncomms4365_CR21
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg3230
– ident: BFncomms4365_CR26
  doi: 10.1371/journal.pbio.1001046
– volume: 137
  start-page: 1194
  year: 2009
  ident: BFncomms4365_CR55
  publication-title: Cell
  doi: 10.1016/j.cell.2009.06.001
– volume: 287
  start-page: 40003
  year: 2012
  ident: BFncomms4365_CR43
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.382416
– volume: 41
  start-page: 240
  year: 2009
  ident: BFncomms4365_CR1
  publication-title: Nat. Genet.
  doi: 10.1038/ng.286
– volume: 8
  start-page: e1002956
  year: 2012
  ident: BFncomms4365_CR44
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1002956
– volume: 93
  start-page: 876
  year: 2013
  ident: BFncomms4365_CR6
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2013.10.004
– volume: 5
  start-page: e1000529
  year: 2009
  ident: BFncomms4365_CR59
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1000529
– volume: 20
  start-page: 320
  year: 2010
  ident: BFncomms4365_CR8
  publication-title: Genome Res.
  doi: 10.1101/gr.101907.109
– volume: 21
  start-page: 4980
  year: 2012
  ident: BFncomms4365_CR36
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/dds334
– ident: BFncomms4365_CR60
  doi: 10.1038/nature09534
– volume: 12
  start-page: 277
  year: 2011
  ident: BFncomms4365_CR15
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg2969
– volume: 500
  start-page: 415
  year: 2013
  ident: BFncomms4365_CR14
  publication-title: Nature
  doi: 10.1038/nature12477
– volume: 479
  start-page: 74
  year: 2011
  ident: BFncomms4365_CR39
  publication-title: Nature
  doi: 10.1038/nature10442
– ident: BFncomms4365_CR17
– volume: 22
  start-page: 1680
  year: 2012
  ident: BFncomms4365_CR27
  publication-title: Genome Res.
  doi: 10.1101/gr.136101.111
– volume: 2
  start-page: a001008
  year: 2010
  ident: BFncomms4365_CR47
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a001008
– volume: 85
  start-page: 679
  year: 2009
  ident: BFncomms4365_CR20
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2009.09.012
– volume: 13
  start-page: R7
  year: 2012
  ident: BFncomms4365_CR25
  publication-title: Genome Biol.
  doi: 10.1186/gb-2012-13-1-r7
– volume: 452
  start-page: 638
  year: 2008
  ident: BFncomms4365_CR32
  publication-title: Nature
  doi: 10.1038/nature06846
– volume: 36
  start-page: D83
  year: 2008
  ident: BFncomms4365_CR64
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkm875
– volume: 275
  start-page: 29915
  year: 2000
  ident: BFncomms4365_CR53
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M001538200
– volume: 8
  start-page: 203
  year: 2008
  ident: BFncomms4365_CR19
  publication-title: BMC Public Health
  doi: 10.1186/1471-2458-8-203
– volume: 13
  start-page: 484
  year: 2012
  ident: BFncomms4365_CR18
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg3230
– volume: 40
  start-page: 1404
  year: 2008
  ident: BFncomms4365_CR34
  publication-title: Nat. Genet.
  doi: 10.1038/ng.254
– volume: 44
  start-page: 502
  year: 2012
  ident: BFncomms4365_CR40
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2205
– volume: 10
  start-page: 1
  year: 2012
  ident: BFncomms4365_CR16
  publication-title: Vital. Health. Stat.
– volume: 13
  start-page: R84
  year: 2012
  ident: BFncomms4365_CR49
  publication-title: Genome Biol.
  doi: 10.1186/gb-2012-13-10-r84
– volume: 132
  start-page: 1811
  year: 2013
  ident: BFncomms4365_CR37
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.27870
– volume: 12
  start-page: R10
  year: 2011
  ident: BFncomms4365_CR7
  publication-title: Genome Biol.
  doi: 10.1186/gb-2011-12-1-r10
– volume: 466
  start-page: 253
  year: 2010
  ident: BFncomms4365_CR9
  publication-title: Nature
  doi: 10.1038/nature09165
– ident: BFncomms4365_CR22
  doi: 10.1038/nature07385
– volume: 14
  start-page: 62
  year: 2013
  ident: BFncomms4365_CR52
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg3345
– volume: 337
  start-page: 1190
  year: 2012
  ident: BFncomms4365_CR24
  publication-title: Science
  doi: 10.1126/science.1222794
– volume: 40
  start-page: 1407
  year: 2008
  ident: BFncomms4365_CR33
  publication-title: Nat. Genet.
  doi: 10.1038/ng.273
– volume: 24
  start-page: 336
  year: 2005
  ident: BFncomms4365_CR57
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7600509
– volume: 55
  start-page: 997
  year: 1999
  ident: BFncomms4365_CR61
  publication-title: Biometrics
  doi: 10.1111/j.0006-341X.1999.00997.x
– volume: 98
  start-page: 387
  year: 1999
  ident: BFncomms4365_CR56
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81967-4
– volume: 16
  start-page: 547
  year: 2007
  ident: BFncomms4365_CR2
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddm010
– volume: 489
  start-page: 75
  year: 2012
  ident: BFncomms4365_CR28
  publication-title: Nature
  doi: 10.1038/nature11232
– volume: 4
  start-page: P3
  year: 2003
  ident: BFncomms4365_CR23
  publication-title: Genome Biol.
  doi: 10.1186/gb-2003-4-5-p3
– volume: 43
  start-page: 630
  year: 2011
  ident: BFncomms4365_CR54
  publication-title: Nat. Genet.
  doi: 10.1038/ng.857
– volume: 153
  start-page: 38
  year: 2013
  ident: BFncomms4365_CR12
  publication-title: Cell
  doi: 10.1016/j.cell.2013.03.008
– volume: 43
  start-page: 513
  year: 2011
  ident: BFncomms4365_CR46
  publication-title: Nat. Genet.
  doi: 10.1038/ng.840
– volume: 6
  start-page: e1000952
  year: 2010
  ident: BFncomms4365_CR3
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1000952
– volume: 41
  start-page: 178
  year: 2009
  ident: BFncomms4365_CR13
  publication-title: Nat. Genet.
  doi: 10.1038/ng.298
– volume: 5
  start-page: 24
  year: 2011
  ident: BFncomms4365_CR62
  publication-title: Ann. Appl. Stat.
  doi: 10.1214/10-AOAS400
SSID ssj0000391844
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Snippet The genetic regulation of the human epigenome is not fully appreciated. Here we describe the effects of genetic variants on the DNA methylome in human lung...
SourceID pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 3365
SubjectTerms 631/208/2489/2487/2486
631/208/726/649
631/67/1612
Breast - metabolism
Carcinogenesis
CpG Islands - genetics
DNA Methylation
Epistasis, Genetic
Gene mapping
Genetic diversity
Genetic Predisposition to Disease - ethnology
Genetic Predisposition to Disease - genetics
Genetic variance
Genetic Variation
Genome-Wide Association Study
Genotype
Health risks
Humanities and Social Sciences
Humans
Hypersensitivity
Kidney - metabolism
Lung - metabolism
Lung cancer
Lung Neoplasms - ethnology
Lung Neoplasms - genetics
multidisciplinary
Polymorphism, Single Nucleotide
Promoter Regions, Genetic - genetics
Quantitative Trait Loci - genetics
Risk Factors
Science
Science (multidisciplinary)
White People - genetics
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Title Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue
URI https://link.springer.com/article/10.1038/ncomms4365
https://www.ncbi.nlm.nih.gov/pubmed/24572595
https://www.proquest.com/docview/1502606688
https://www.proquest.com/docview/1503551301
https://pubmed.ncbi.nlm.nih.gov/PMC3982882
Volume 5
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