Mitochondrial and metabolic dysfunction of peripheral immune cells in multiple sclerosis

• Published in: Journal of neuroinflammation Vol. 21; no. 1; pp. 28 - 19
• Main Authors: Wang, Peng-Fei, Jiang, Fei, Zeng, Qiu-Ming, Yin, Wei-Fan, Hu, Yue-Zi, Li, Qiao, Hu, Zhao-Lan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.01.2024; BioMed Central; BMC
• Subjects: Analysis; Antigens; Apoptosis; Care and treatment; Chemokines; Cytokines; Cytology; Cytotoxicity; Demyelination; Diagnosis; Immune cells; Immune response; Immune system; Immune-metabolic; Inflammation; Lymphocytes; Magnetic resonance imaging; Metabolism; Mitochondria; Mitochondrial DNA; Mitochondrion; Multiple sclerosis; Nerves; Neurodegeneration; Pathogenesis; Phosphorylation; Proteins; T cell receptors; Therapeutic targets; Tumor necrosis factor-TNF; China; Mitochondrion; Immune-metabolic; Immune cells; MS

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the infiltration of inflammatory cells and demyelination of nerves. Mitochondrial dysfunction has been implicated in the pathogenesis of MS, as studies have shown abnormalities in mitochondrial activities, metabolism, mitochon...