Mitochondrial and metabolic dysfunction of peripheral immune cells in multiple sclerosis

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the infiltration of inflammatory cells and demyelination of nerves. Mitochondrial dysfunction has been implicated in the pathogenesis of MS, as studies have shown abnormalities in mitochondrial activities, metabolism, mitochon...

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Published inJournal of neuroinflammation Vol. 21; no. 1; pp. 28 - 19
Main Authors Wang, Peng-Fei, Jiang, Fei, Zeng, Qiu-Ming, Yin, Wei-Fan, Hu, Yue-Zi, Li, Qiao, Hu, Zhao-Lan
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 20.01.2024
BioMed Central
BMC
Subjects
Analysis
Antigens
Apoptosis
Care and treatment
Chemokines
Cytokines
Cytology
Cytotoxicity
Demyelination
Diagnosis
Immune cells
Immune response
Immune system
Immune-metabolic
Inflammation
Lymphocytes
Magnetic resonance imaging
Metabolism
Mitochondria
Mitochondrial DNA
Mitochondrion
Multiple sclerosis
Nerves
Neurodegeneration
Pathogenesis
Phosphorylation
Proteins
T cell receptors
Therapeutic targets
Tumor necrosis factor-TNF
China
Mitochondrion
Immune-metabolic
Immune cells
MS
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Abstract Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the infiltration of inflammatory cells and demyelination of nerves. Mitochondrial dysfunction has been implicated in the pathogenesis of MS, as studies have shown abnormalities in mitochondrial activities, metabolism, mitochondrial DNA (mtDNA) levels, and mitochondrial morphology in immune cells of individuals with MS. The presence of mitochondrial dysfunctions in immune cells contributes to immunological dysregulation and neurodegeneration in MS. This review provided a comprehensive overview of mitochondrial dysfunction in immune cells associated with MS, focusing on the potential consequences of mitochondrial metabolic reprogramming on immune function. Current challenges and future directions in the field of immune-metabolic MS and its potential as a therapeutic target were also discussed.
AbstractList Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the infiltration of inflammatory cells and demyelination of nerves. Mitochondrial dysfunction has been implicated in the pathogenesis of MS, as studies have shown abnormalities in mitochondrial activities, metabolism, mitochondrial DNA (mtDNA) levels, and mitochondrial morphology in immune cells of individuals with MS. The presence of mitochondrial dysfunctions in immune cells contributes to immunological dysregulation and neurodegeneration in MS. This review provided a comprehensive overview of mitochondrial dysfunction in immune cells associated with MS, focusing on the potential consequences of mitochondrial metabolic reprogramming on immune function. Current challenges and future directions in the field of immune-metabolic MS and its potential as a therapeutic target were also discussed.
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the infiltration of inflammatory cells and demyelination of nerves. Mitochondrial dysfunction has been implicated in the pathogenesis of MS, as studies have shown abnormalities in mitochondrial activities, metabolism, mitochondrial DNA (mtDNA) levels, and mitochondrial morphology in immune cells of individuals with MS. The presence of mitochondrial dysfunctions in immune cells contributes to immunological dysregulation and neurodegeneration in MS. This review provided a comprehensive overview of mitochondrial dysfunction in immune cells associated with MS, focusing on the potential consequences of mitochondrial metabolic reprogramming on immune function. Current challenges and future directions in the field of immune-metabolic MS and its potential as a therapeutic target were also discussed. Keywords: Mitochondrion, Immune-metabolic, Immune cells, MS
Abstract Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the infiltration of inflammatory cells and demyelination of nerves. Mitochondrial dysfunction has been implicated in the pathogenesis of MS, as studies have shown abnormalities in mitochondrial activities, metabolism, mitochondrial DNA (mtDNA) levels, and mitochondrial morphology in immune cells of individuals with MS. The presence of mitochondrial dysfunctions in immune cells contributes to immunological dysregulation and neurodegeneration in MS. This review provided a comprehensive overview of mitochondrial dysfunction in immune cells associated with MS, focusing on the potential consequences of mitochondrial metabolic reprogramming on immune function. Current challenges and future directions in the field of immune-metabolic MS and its potential as a therapeutic target were also discussed.
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the infiltration of inflammatory cells and demyelination of nerves. Mitochondrial dysfunction has been implicated in the pathogenesis of MS, as studies have shown abnormalities in mitochondrial activities, metabolism, mitochondrial DNA (mtDNA) levels, and mitochondrial morphology in immune cells of individuals with MS. The presence of mitochondrial dysfunctions in immune cells contributes to immunological dysregulation and neurodegeneration in MS. This review provided a comprehensive overview of mitochondrial dysfunction in immune cells associated with MS, focusing on the potential consequences of mitochondrial metabolic reprogramming on immune function. Current challenges and future directions in the field of immune-metabolic MS and its potential as a therapeutic target were also discussed.Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the infiltration of inflammatory cells and demyelination of nerves. Mitochondrial dysfunction has been implicated in the pathogenesis of MS, as studies have shown abnormalities in mitochondrial activities, metabolism, mitochondrial DNA (mtDNA) levels, and mitochondrial morphology in immune cells of individuals with MS. The presence of mitochondrial dysfunctions in immune cells contributes to immunological dysregulation and neurodegeneration in MS. This review provided a comprehensive overview of mitochondrial dysfunction in immune cells associated with MS, focusing on the potential consequences of mitochondrial metabolic reprogramming on immune function. Current challenges and future directions in the field of immune-metabolic MS and its potential as a therapeutic target were also discussed.
ArticleNumber 28
Audience Academic
Author Jiang, Fei
Li, Qiao
Yin, Wei-Fan
Wang, Peng-Fei
Hu, Zhao-Lan
Hu, Yue-Zi
Zeng, Qiu-Ming
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  surname: Hu
  fullname: Hu, Zhao-Lan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38243312$$D View this record in MEDLINE/PubMed
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Snippet Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the infiltration of inflammatory cells and demyelination of nerves. Mitochondrial...
Abstract Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the infiltration of inflammatory cells and demyelination of nerves....
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SubjectTerms Analysis
Antigens
Apoptosis
Care and treatment
Chemokines
Cytokines
Cytology
Cytotoxicity
Demyelination
Diagnosis
Immune cells
Immune response
Immune system
Immune-metabolic
Inflammation
Lymphocytes
Magnetic resonance imaging
Metabolism
Mitochondria
Mitochondrial DNA
Mitochondrion
Multiple sclerosis
Nerves
Neurodegeneration
Pathogenesis
Phosphorylation
Proteins
T cell receptors
Therapeutic targets
Tumor necrosis factor-TNF
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Title Mitochondrial and metabolic dysfunction of peripheral immune cells in multiple sclerosis
URI https://www.ncbi.nlm.nih.gov/pubmed/38243312
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