Loss of Vascular Distensibility During Exercise Is an Early Hemodynamic Marker of Pulmonary Vascular Disease

• Published in: Chest Vol. 149; no. 2; p. 353
• Main Authors: Lau, Edmund M T, Chemla, Denis, Godinas, Laurent, Zhu, Kaixian, Sitbon, Olivier, Savale, Laurent, Montani, David, Jaïs, Xavier, Celermajer, David S, Simonneau, Gérald, Humbert, Marc, Hervé, Philippe
• Format: Journal Article
• Language: English
• Published: United States 01.02.2016
• Subjects: Cardiac Catheterization; Exercise - physiology; Exercise Test; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary - diagnosis; Hypertension, Pulmonary - physiopathology; Male; Middle Aged; Pulmonary Artery - physiopathology; Pulmonary Circulation - physiology; Pulmonary Wedge Pressure - physiology; Retrospective Studies; Severity of Illness Index; Time Factors; Vascular Resistance; exercise; pulmonary arterial hypertension; pulmonary hypertension; hemodynamics

Exercise can distend the normally compliant, thin-walled pulmonary vessels. Loss of distensibility has been suggested as an early marker of pulmonary vascular remodeling. We hypothesized that in mild pulmonary vascular disease (PVD), a reduction in vascular distensibility during exercise occurs prio...