Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis

• Published in: Respiratory research Vol. 24; no. 1; pp. 287 - 12
• Main Authors: Blumhagen, Rachel Z., Kurche, Jonathan S., Cool, Carlyne D., Walts, Avram D., Heinz, David, Fingerlin, Tasha E., Yang, Ivana V., Schwartz, David A.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.11.2023; BioMed Central; BMC
• Subjects: Alveoli; Analysis; Care and treatment; Cytokeratin; Deactivation; Development and progression; Endoplasmic reticulum; Epithelium; Eukaryotic Initiation Factor-2 - genetics; Eukaryotic Initiation Factor-2 - metabolism; Fibrosis; Gene expression; Genetic aspects; Geospatial data; Heat shock proteins; Humans; Idiopathic Pulmonary Fibrosis - metabolism; Immunofluorescence; Lung - metabolism; Lung cancer; Lung diseases; Metaplasia; Morphology; Parenchyma; Pulmonary fibrosis; RNA sequencing; Signal transduction; Smooth muscle; Spatial discrimination; Spatial resolution; Stress proteins; Therapeutic targets; Tissues; Transcription; Transcriptome; Transcriptomes; Transcriptomics; Wound healing; United States
• ISSN: 1465-993X; 1465-9921; 1465-993X
• DOI: 10.1186/s12931-023-02572-6

Idiopathic pulmonary fibrosis (IPF) is a heterogeneous disease that is pathologically characterized by areas of normal-appearing lung parenchyma, active fibrosis (transition zones including fibroblastic foci) and dense fibrosis. Defining transcriptional differences between these pathologically heter...