Influences of Organic Cation Transporter Polymorphisms on the Population Pharmacokinetics of Metformin in Healthy Subjects

• Published in: The AAPS journal Vol. 15; no. 2; pp. 571 - 580
• Main Authors: Yoon, Hwa, Cho, Hea-Young, Yoo, Hee-Doo, Kim, Se-Mi, Lee, Yong-Bok
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.04.2013
• Subjects: Administration, Oral; Adult; Analysis of Variance; Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Chi-Square Distribution; Drug Dosage Calculations; Gene Frequency; Genotype; Half-Life; Humans; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - blood; Hypoglycemic Agents - pharmacokinetics; Male; Metabolic Clearance Rate; Metformin - administration & dosage; Metformin - blood; Metformin - pharmacokinetics; Models, Biological; Nonlinear Dynamics; Organic Cation Transport Proteins - genetics; Organic Cation Transport Proteins - metabolism; Organic Cation Transporter 2; Pharmacogenetics; Pharmacology/Toxicology; Pharmacy; Phenotype; Polymorphism, Genetic; Randomized Controlled Trials as Topic; Research Article; Retrospective Studies; Young Adult; metformin; genetic polymorphism; OCTs; population pharmacokinetics

This study investigated the effects of genetic polymorphisms in organic cation transporter (OCT) genes, such as OCT1-3, OCTN1, MATE1, and MATE2-K, on metformin pharmacokinetics. Of particular interest was the influence of genetic polymorphisms as covariates on the variability in the population pharm...