Influences of Organic Cation Transporter Polymorphisms on the Population Pharmacokinetics of Metformin in Healthy Subjects - Yoon, Hwa; Cho, Hea-Young; Yoo, Hee-Doo; Kim, Se-Mi; Lee, Yong-Bok (The AAPS journal, 2013)
Keywords: Administration, Oral; Adult; Analysis of Variance; Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Chi-Square Distribution; Drug Dosage Calculations; Gene Frequency; Genotype; Half-Life; Humans; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - blood; Hypoglycemic Agents - pharmacokinetics; Male; Metabolic Clearance Rate; Metformin - administration & dosage; Metformin - blood; Metformin - pharmacokinetics; Models, Biological; Nonlinear Dynamics; Organic Cation Transport Proteins - genetics; Organic Cation Transport Proteins - metabolism; Organic Cation Transporter 2; Pharmacogenetics; Pharmacology/Toxicology; Pharmacy; Phenotype; Polymorphism, Genetic; Randomized Controlled Trials as Topic; Research Article; Retrospective Studies; Young Adult; metformin; genetic polymorphism; OCTs; population pharmacokinetics