Berberrubine, a Main Metabolite of Berberine, Alleviates Non-Alcoholic Fatty Liver Disease via Modulating Glucose and Lipid Metabolism and Restoring Gut Microbiota

• Published in: Frontiers in pharmacology Vol. 13; p. 913378
• Main Authors: Yang, Sa, Cao, Shijie, Li, Congyu, Zhang, Jichao, Liu, Chang, Qiu, Feng, Kang, Ning
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 08.07.2022
• Subjects: berberine; berberrubine; glucose and lipid metabolism; gut microbiota; NAFLD; Pharmacology

Non-alcoholic fatty liver disease (NAFLD) is a major public health problem in many countries. Berberine (BBR) is an effective therapeutic agent in alleviating NAFLD. Berberrubine (BRB) is one of the main active metabolites of BBR, which shows significant anti-obesity and antihypoglycemic effects. Ho...