Effects of Aging on Cortical Neural Dynamics and Local Sleep Homeostasis in Mice

• Published in: The Journal of neuroscience Vol. 38; no. 16; pp. 3911 - 3928
• Main Authors: McKillop, Laura E., Fisher, Simon P., Cui, Nanyi, Peirson, Stuart N., Foster, Russell G., Wafford, Keith A., Vyazovskiy, Vladyslav V.
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 18.04.2018
• Subjects: Aging; Aging - physiology; Animals; Architecture; Cortex (motor); Cortical Excitability; EEG; Electrophysiological recording; Eye movements; Homeostasis; Life span; Male; Mice; Mice, Inbred C57BL; Motor Cortex - cytology; Motor Cortex - growth & development; Motor Cortex - physiology; Motors; Neurons - physiology; NREM sleep; Oscillations; REM sleep; Senescence; Sleep; Sleep and wakefulness; Sleep deprivation; Sleep Stages; sleep; neocortex; aging; mice

Healthy aging is associated with marked effects on sleep, including its daily amount and architecture, as well as the specific EEG oscillations. Neither the neurophysiological underpinnings nor the biological significance of these changes are understood, and crucially the question remains whether ag...