Wall teichoic acid-dependent phagocytosis of intact cell walls of Lactiplantibacillus plantarum elicits IL-12 secretion from macrophages

• Published in: Frontiers in microbiology Vol. 13; p. 986396
• Main Authors: Kojima, Naoya, Kojima, Shohei, Hosokawa, Shin, Oda, Yoshiki, Zenke, Daisuke, Toura, Yuta, Onohara, Emi, Yokota, Shin-ichi, Nagaoka, Masato, Kuroda, Yasuhiro
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 09.08.2022
• Subjects: actin remodeling; cell wall teichoic acid; IL-12; intact cell wall; Lactiplantibacillus plantarum; macrophage; Microbiology

Selected lactic acid bacteria can stimulate macrophages and dendritic cells to secrete IL-12, which plays a key role in activating innate and cellular immunity. In this study, we investigated the roles of cell wall teichoic acids (WTAs) displayed on whole intact cell walls (ICWs) of Lactiplantibacil...