CNS Hypomyelination Disrupts Axonal Conduction and Behavior in Larval Zebrafish

• Published in: The Journal of neuroscience Vol. 41; no. 44; pp. 9099 - 9111
• Main Authors: Madden, M. E., Suminaite, D., Ortiz, E., Early, J. J., Koudelka, S., Livesey, M. R., Bianco, I. H., Granato, M., Lyons, D. A.
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 03.11.2021
• Subjects: Acoustic Stimulation; Action potential; Action Potentials; Animals; Axons; Axons - metabolism; Axons - physiology; Central nervous system; Central Nervous System - metabolism; Central Nervous System - physiology; Circuits; Conduction; Danio rerio; Firing rate; Investigations; Larva - physiology; Larvae; Latency; Membrane Proteins; Mutants; Mutation; Myelin; Myelin Sheath - metabolism; Myelination; Reflex, Startle; Startle response; Stimuli; Transcription Factors; Zebrafish; Zebrafish - growth & development; Zebrafish - metabolism; Zebrafish Proteins; myelin; myrf; zebrafish; electrophysiology; circuit function; oligodendrocyte

Myelination is essential for central nervous system (CNS) formation, health and function. As a model organism, larval zebrafish have been extensively employed to investigate the molecular and cellular basis of CNS myelination, because of their genetic tractability and suitability for non-invasive li...