Effect of bupropion on hippocampal neurotransmitters and on peripheral hormonal concentrations in the rat
Departments of 1 Human Physiology and Sportsmedicine and 3 Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel, 1050 Brussels, Belgium; and 2 University Institute of Sport Sciences, 00194 Rome, Italy Submitted 18 November 2002 ; accepted in final form 8 April 2003 The purpose of t...
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Published in | Journal of applied physiology (1985) Vol. 95; no. 2; pp. 652 - 656 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Bethesda, MD
Am Physiological Soc
01.08.2003
American Physiological Society |
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Abstract | Departments of 1 Human Physiology and
Sportsmedicine and 3 Pharmaceutical Chemistry and Drug
Analysis, Vrije Universiteit Brussel, 1050 Brussels, Belgium; and
2 University Institute of Sport Sciences, 00194 Rome,
Italy
Submitted 18 November 2002
; accepted in final form 8 April 2003
The purpose of the present study was to administer an acute dose of the
dual dopamine norepinephrine reuptake blocker bupropion in freely moving rats
and to monitor the extracellular neurotransmitter concentrations in the
hippocampus via in vivo microdialysis and the peripheral hormonal
concentrations via catheterization. A microdialysis probe was inserted in the
hippocampus, and samples for serotonin, dopamine, and norepinephrine were
collected every 20 min before and after the injection of 17 mg/kg of
bupropion, for a total sampling time of 180 min. A catheter was placed in the
vena femoralis of the second group of rats, and blood samples were collected
before and after bupropion injection for quantification of growth hormone,
prolactin, corticosterone, adrenocorticotropin hormone, and -endorphins.
All neurotransmitter levels (dopamine, norepinephrine, and serotonin)
significantly increased after bupropion injection. This was accompanied by a
significant decrease in prolactin concentrations, whereas the other hormones
showed no statistically significant variation. It can, therefore, be concluded
that, although bupropion has dual reuptake proprieties, the observed effects
both at the central and at the peripheral level seem to be ruled by the
dopaminergic system.
dopamine and norepinephrine reuptake inhibitor; hippocampus; hypothalamic-pituitary-adrenal axis; microdialysis; neurotransmitters.
Address for reprint requests and other correspondence: R. Meeusen, Dept. of
Human Physiology and Sportsmedicine, Free Univ. Brussel, Pleinlaan 2, 1050
Brussels, Belgium (E-mail:
rmeeusen{at}vub.ac.be ). |
---|---|
AbstractList | The purpose of the present study was to administer an acute dose of the dual dopamine norepinephrine reuptake blocker bupropion in freely moving rats and to monitor the extracellular neurotransmitter concentrations in the hippocampus via in vivo microdialysis and the peripheral hormonal concentrations via catheterization. A microdialysis probe was inserted in the hippocampus, and samples for serotonin, dopamine, and norepinephrine were collected every 20 min before and after the injection of 17 mg/kg of bupropion, for a total sampling time of 180 min. A catheter was placed in the vena femoralis of the second group of rats, and blood samples were collected before and after bupropion injection for quantification of growth hormone, prolactin, corticosterone, adrenocorticotropin hormone, and beta-endorphins. All neurotransmitter levels (dopamine, norepinephrine, and serotonin) significantly increased after bupropion injection. This was accompanied by a significant decrease in prolactin concentrations, whereas the other hormones showed no statistically significant variation. It can, therefore, be concluded that, although bupropion has dual reuptake proprieties, the observed effects both at the central and at the peripheral level seem to be ruled by the dopaminergic system. The purpose of the present study was to administer an acute dose of the dual dopamine norepinephrine reuptake blocker bupropion in freely moving rats and to monitor the extracellular neurotransmitter concentrations in the hippocampus via in vivo microdialysis and the peripheral hormonal concentrations via catheterization. A microdialysis probe was inserted in the hippocampus, and samples for serotonin, dopamine, and norepinephrine were collected every 20 min before and after the injection of 17 mg/kg of bupropion, for a total sampling time of 180 min. A catheter was placed in the vena femoralis of the second group of rats, and blood samples were collected before and after bupropion injection for quantification of growth hormone, prolactin, corticosterone, adrenocorticotropin hormone, and β-endorphins. All neurotransmitter levels (dopamine, norepinephrine, and serotonin) significantly increased after bupropion injection. This was accompanied by a significant decrease in prolactin concentrations, whereas the other hormones showed no statistically significant variation. It can, therefore, be concluded that, although bupropion has dual reuptake proprieties, the observed effects both at the central and at the peripheral level seem to be ruled by the dopaminergic system. The purpose of the present study was to administer an acute dose of the dual dopamine norepinephrine reuptake blocker bupropion in freely moving rats and to monitor the extracellular neurotransmitter concentrations in the hippocampus via in vivo microdialysis and the peripheral hormonal concentrations via catheterization. A microdialysis probe was inserted in the hippocampus, and samples for serotonin, dopamine, and norepinephrine were collected every 20 min before and after the injection of 17 mg/kg of bupropion, for a total sampling time of 180 min. A catheter was placed in the vena femoralis of the second group of rats, and blood samples were collected before and after bupropion injection for quantification of growth hormone, prolactin, corticosterone, adrenocorticotropin hormone, and [beta]-endorphins. All neurotransmitter levels (dopamine, norepinephrine, and serotonin) significantly increased after bupropion injection. This was accompanied by a significant decrease in prolactin concentrations, whereas the other hormones showed no statistically significant variation. It can, therefore, be concluded that, although bupropion has dual reuptake proprieties, the observed effects both at the central and at the peripheral level seem to be ruled by the dopaminergic system. [PUBLICATION ABSTRACT] Departments of 1 Human Physiology and Sportsmedicine and 3 Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel, 1050 Brussels, Belgium; and 2 University Institute of Sport Sciences, 00194 Rome, Italy Submitted 18 November 2002 ; accepted in final form 8 April 2003 The purpose of the present study was to administer an acute dose of the dual dopamine norepinephrine reuptake blocker bupropion in freely moving rats and to monitor the extracellular neurotransmitter concentrations in the hippocampus via in vivo microdialysis and the peripheral hormonal concentrations via catheterization. A microdialysis probe was inserted in the hippocampus, and samples for serotonin, dopamine, and norepinephrine were collected every 20 min before and after the injection of 17 mg/kg of bupropion, for a total sampling time of 180 min. A catheter was placed in the vena femoralis of the second group of rats, and blood samples were collected before and after bupropion injection for quantification of growth hormone, prolactin, corticosterone, adrenocorticotropin hormone, and -endorphins. All neurotransmitter levels (dopamine, norepinephrine, and serotonin) significantly increased after bupropion injection. This was accompanied by a significant decrease in prolactin concentrations, whereas the other hormones showed no statistically significant variation. It can, therefore, be concluded that, although bupropion has dual reuptake proprieties, the observed effects both at the central and at the peripheral level seem to be ruled by the dopaminergic system. dopamine and norepinephrine reuptake inhibitor; hippocampus; hypothalamic-pituitary-adrenal axis; microdialysis; neurotransmitters. Address for reprint requests and other correspondence: R. Meeusen, Dept. of Human Physiology and Sportsmedicine, Free Univ. Brussel, Pleinlaan 2, 1050 Brussels, Belgium (E-mail: rmeeusen{at}vub.ac.be ). |
Author | Clinckers, R Sarre, S Ebinger, G Piacentini, M. F Meeusen, R Michotte, Y |
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Cites_doi | 10.1055/s-2007-972683 10.1097/00005768-200207000-00021 10.1016/0024-3205(79)90474-0 10.1016/0893-133X(89)90031-6 10.1016/0024-3205(82)90306-X 10.1385/0-89603-394-5:185 10.1055/s-2001-15648 10.1002/(SICI)1097-4547(19980601)52:5<591::AID-JNR11>3.0.CO;2-5 10.1159/000126835 10.1016/0047-6374(95)01635-X 10.1677/joe.0.1690205 10.1080/17461390200072203 10.1017/S0033291700039593 10.1038/npp.1994.43 10.1016/S0166-4328(01)00361-8 10.1007/s002130050443 10.1097/00005768-199701000-00008 |
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Keywords | Animal model Rat Hypothalamohypophysoadrenal axis Psychotropic Rodentia Central nervous system Encephalon Dose activity relation Vertebrata Mammalia Bupropion Animal Neurotransmitter Antidepressant agent Hippocampus |
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Sportsmedicine and 3 Pharmaceutical Chemistry and Drug
Analysis, Vrije Universiteit Brussel, 1050 Brussels, Belgium; and... The purpose of the present study was to administer an acute dose of the dual dopamine norepinephrine reuptake blocker bupropion in freely moving rats and to... |
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SubjectTerms | Animals Biological and medical sciences Brain Bupropion - pharmacology Dopamine - metabolism Dopamine Uptake Inhibitors - pharmacology Drugs Extracellular Space - metabolism Hippocampus - drug effects Hippocampus - metabolism Hormones Male Medical sciences Microdialysis Nervous system Neuropharmacology Neurotransmitter Agents - metabolism Neurotransmitters Norepinephrine - metabolism Osmolar Concentration Pharmacology. Drug treatments Prolactin - blood Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Wistar Rodents Serotonin - metabolism |
Title | Effect of bupropion on hippocampal neurotransmitters and on peripheral hormonal concentrations in the rat |
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