Anterior Cingulate Cortex to Ventral Hippocampus Circuit Mediates Contextual Fear Generalization

• Published in: The Journal of neuroscience Vol. 39; no. 29; pp. 5728 - 5739
• Main Authors: Bian, Xin-Lan, Qin, Cheng, Cai, Cheng-Yun, Zhou, Ying, Tao, Yan, Lin, Yu-Hui, Wu, Hai-Yin, Chang, Lei, Luo, Chun-Xia, Zhu, Dong-Ya
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 17.07.2019
• Subjects: Anxiety; c-Fos protein; Circuits; Cortex (cingulate); Fear; Fibers; Hippocampus; Mental disorders; Neurons; Post traumatic stress disorder; Psychological stress; contextual fear memory; neural circuit; anxiety disorders; ventral hippocampus; anterior cingulate cortex; memory generalization

Contextual fear memory becomes less context-specific over time, a phenomenon referred to as contextual fear generalization. Overgeneralization of contextual fear memory is a core symptom of post-traumatic stress disorder (PTSD), but circuit mechanisms underlying the generalization remain unclear. We...