A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities

• Published in: Molecular cell Vol. 70; no. 3; pp. 408 - 421.e8
• Main Authors: Conway, Eric, Jerman, Emilia, Healy, Evan, Ito, Shinsuke, Holoch, Daniel, Oliviero, Giorgio, Deevy, Orla, Glancy, Eleanor, Fitzpatrick, Darren J., Mucha, Marlena, Watson, Ariane, Rice, Alan M., Chammas, Paul, Huang, Christine, Pratt-Kelly, Indigo, Koseki, Yoko, Nakayama, Manabu, Ishikura, Tomoyuki, Streubel, Gundula, Wynne, Kieran, Hokamp, Karsten, McLysaght, Aoife, Ciferri, Claudio, Di Croce, Luciano, Cagney, Gerard, Margueron, Raphaël, Koseki, Haruhiko, Bracken, Adrian P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.05.2018; Cell Press
• Subjects: AEBP2; C10ORF12; EZH2; H3K27me2; H3K27me3; LCOR; Life Sciences; PALI1; polycomb; PRC2; PRC2; AEBP2; PALI1; polycomb; LCOR; C10ORF12; H3K27me2; EZH2; H3K27me3

The polycomb repressive complex 2 (PRC2) consists of core subunits SUZ12, EED, RBBP4/7, and EZH1/2 and is responsible for mono-, di-, and tri-methylation of lysine 27 on histone H3. Whereas two distinct forms exist, PRC2.1 (containing one polycomb-like protein) and PRC2.2 (containing AEBP2 and JARID...