A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities

The polycomb repressive complex 2 (PRC2) consists of core subunits SUZ12, EED, RBBP4/7, and EZH1/2 and is responsible for mono-, di-, and tri-methylation of lysine 27 on histone H3. Whereas two distinct forms exist, PRC2.1 (containing one polycomb-like protein) and PRC2.2 (containing AEBP2 and JARID...

Full description

Saved in:
Bibliographic Details
Published inMolecular cell Vol. 70; no. 3; pp. 408 - 421.e8
Main Authors Conway, Eric, Jerman, Emilia, Healy, Evan, Ito, Shinsuke, Holoch, Daniel, Oliviero, Giorgio, Deevy, Orla, Glancy, Eleanor, Fitzpatrick, Darren J., Mucha, Marlena, Watson, Ariane, Rice, Alan M., Chammas, Paul, Huang, Christine, Pratt-Kelly, Indigo, Koseki, Yoko, Nakayama, Manabu, Ishikura, Tomoyuki, Streubel, Gundula, Wynne, Kieran, Hokamp, Karsten, McLysaght, Aoife, Ciferri, Claudio, Di Croce, Luciano, Cagney, Gerard, Margueron, Raphaël, Koseki, Haruhiko, Bracken, Adrian P.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 03.05.2018
Cell Press
Subjects
AEBP2
C10ORF12
EZH2
H3K27me2
H3K27me3
LCOR
Life Sciences
PALI1
polycomb
PRC2
PRC2
AEBP2
PALI1
polycomb
LCOR
C10ORF12
H3K27me2
EZH2
H3K27me3
Online AccessGet full text

Cover

Abstract The polycomb repressive complex 2 (PRC2) consists of core subunits SUZ12, EED, RBBP4/7, and EZH1/2 and is responsible for mono-, di-, and tri-methylation of lysine 27 on histone H3. Whereas two distinct forms exist, PRC2.1 (containing one polycomb-like protein) and PRC2.2 (containing AEBP2 and JARID2), little is known about their differential functions. Here, we report the discovery of a family of vertebrate-specific PRC2.1 proteins, “PRC2 associated LCOR isoform 1” (PALI1) and PALI2, encoded by the LCOR and LCORL gene loci, respectively. PALI1 promotes PRC2 methyltransferase activity in vitro and in vivo and is essential for mouse development. Pali1 and Aebp2 define mutually exclusive, antagonistic PRC2 subtypes that exhibit divergent H3K27-tri-methylation activities. The balance of these PRC2.1/PRC2.2 activities is required for the appropriate regulation of polycomb target genes during differentiation. PALI1/2 potentially link polycombs with transcriptional co-repressors in the regulation of cellular identity during development and in cancer. [Display omitted] •Pali1 and Pali2 form a new family of vertebrate-specific proteins that bind PRC2•Pali1 promotes PRC2 methyltransferase activity in vitro and in vivo•Pali1 defines a distinct PRC2.1 subtype essential for mouse development•PRC2 subtype balance is essential for proper regulation of Polycomb target genes Pali1 and Pali2 form a new family of vertebrate-specific proteins that bind PRC2. Conway et al. show that Pali1 promotes PRC2 methyltransferase activity and defines a distinct PRC2.1 subtype essential for mouse development. They also establish that the balance of PRC2.1 and PRC2.2 activities is essential for proper regulation of polycomb target genes.
AbstractList The polycomb repressive complex 2 (PRC2) consists of core subunits SUZ12, EED, RBBP4/7, and EZH1/2 and is responsible for mono-, di-, and tri-methylation of lysine 27 on histone H3. Whereas two distinct forms exist, PRC2.1 (containing one polycomb-like protein) and PRC2.2 (containing AEBP2 and JARID2), little is known about their differential functions. Here, we report the discovery of a family of vertebrate-specific PRC2.1 proteins, “PRC2 associated LCOR isoform 1” (PALI1) and PALI2, encoded by the LCOR and LCORL gene loci, respectively. PALI1 promotes PRC2 methyltransferase activity in vitro and in vivo and is essential for mouse development. Pali1 and Aebp2 define mutually exclusive, antagonistic PRC2 subtypes that exhibit divergent H3K27-tri-methylation activities. The balance of these PRC2.1/PRC2.2 activities is required for the appropriate regulation of polycomb target genes during differentiation. PALI1/2 potentially link polycombs with transcriptional co-repressors in the regulation of cellular identity during development and in cancer. [Display omitted] •Pali1 and Pali2 form a new family of vertebrate-specific proteins that bind PRC2•Pali1 promotes PRC2 methyltransferase activity in vitro and in vivo•Pali1 defines a distinct PRC2.1 subtype essential for mouse development•PRC2 subtype balance is essential for proper regulation of Polycomb target genes Pali1 and Pali2 form a new family of vertebrate-specific proteins that bind PRC2. Conway et al. show that Pali1 promotes PRC2 methyltransferase activity and defines a distinct PRC2.1 subtype essential for mouse development. They also establish that the balance of PRC2.1 and PRC2.2 activities is essential for proper regulation of polycomb target genes.
The polycomb repressive complex 2 (PRC2) consists of core subunits SUZ12, EED, RBBP4/7, and EZH1/2 and is responsible for mono-, di-, and tri-methylation of lysine 27 on histone H3. Whereas two distinct forms exist, PRC2.1 (containing one polycomb-like protein) and PRC2.2 (containing AEBP2 and JARID2), little is known about their differential functions. Here, we report the discovery of a family of vertebrate-specific PRC2.1 proteins, "PRC2 associated LCOR isoform 1" (PALI1) and PALI2, encoded by the LCOR and LCORL gene loci, respectively. PALI1 promotes PRC2 methyltransferase activity in vitro and in vivo and is essential for mouse development. Pali1 and Aebp2 define mutually exclusive, antagonistic PRC2 subtypes that exhibit divergent H3K27-tri-methylation activities. The balance of these PRC2.1/PRC2.2 activities is required for the appropriate regulation of polycomb target genes during differentiation. PALI1/2 potentially link polycombs with transcriptional co-repressors in the regulation of cellular identity during development and in cancer.
Author Deevy, Orla
Watson, Ariane
Koseki, Haruhiko
Oliviero, Giorgio
Koseki, Yoko
Cagney, Gerard
Jerman, Emilia
Margueron, Raphaël
Conway, Eric
Holoch, Daniel
Mucha, Marlena
McLysaght, Aoife
Wynne, Kieran
Nakayama, Manabu
Hokamp, Karsten
Ito, Shinsuke
Ciferri, Claudio
Healy, Evan
Chammas, Paul
Streubel, Gundula
Bracken, Adrian P.
Rice, Alan M.
Pratt-Kelly, Indigo
Fitzpatrick, Darren J.
Ishikura, Tomoyuki
Huang, Christine
Di Croce, Luciano
Glancy, Eleanor
Author_xml – sequence: 1
  givenname: Eric
  surname: Conway
  fullname: Conway, Eric
  organization: Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
– sequence: 2
  givenname: Emilia
  surname: Jerman
  fullname: Jerman, Emilia
  organization: Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
– sequence: 3
  givenname: Evan
  surname: Healy
  fullname: Healy, Evan
  organization: Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
– sequence: 4
  givenname: Shinsuke
  surname: Ito
  fullname: Ito, Shinsuke
  organization: Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
– sequence: 5
  givenname: Daniel
  surname: Holoch
  fullname: Holoch, Daniel
  organization: Institut Curie, Paris Sciences et Lettres (PSL) Research University, CNRS UMR 3215, INSERM U934, 75248 Paris Cedex 05, France
– sequence: 6
  givenname: Giorgio
  surname: Oliviero
  fullname: Oliviero, Giorgio
  organization: School of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland
– sequence: 7
  givenname: Orla
  surname: Deevy
  fullname: Deevy, Orla
  organization: Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
– sequence: 8
  givenname: Eleanor
  surname: Glancy
  fullname: Glancy, Eleanor
  organization: Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
– sequence: 9
  givenname: Darren J.
  surname: Fitzpatrick
  fullname: Fitzpatrick, Darren J.
  organization: Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
– sequence: 10
  givenname: Marlena
  surname: Mucha
  fullname: Mucha, Marlena
  organization: Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
– sequence: 11
  givenname: Ariane
  surname: Watson
  fullname: Watson, Ariane
  organization: School of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland
– sequence: 12
  givenname: Alan M.
  surname: Rice
  fullname: Rice, Alan M.
  organization: Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
– sequence: 13
  givenname: Paul
  surname: Chammas
  fullname: Chammas, Paul
  organization: Gene Regulation, Stem Cells and Cancer Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain
– sequence: 14
  givenname: Christine
  surname: Huang
  fullname: Huang, Christine
  organization: Department of Structural Biology, Genentech, San Francisco, CA 94080, USA
– sequence: 15
  givenname: Indigo
  surname: Pratt-Kelly
  fullname: Pratt-Kelly, Indigo
  organization: Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
– sequence: 16
  givenname: Yoko
  surname: Koseki
  fullname: Koseki, Yoko
  organization: Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
– sequence: 17
  givenname: Manabu
  surname: Nakayama
  fullname: Nakayama, Manabu
  organization: Chromosome Engineering Team, Department of Technology Development, Kazusa DNA Research Institute, Kisarazu 292-0818, Japan
– sequence: 18
  givenname: Tomoyuki
  surname: Ishikura
  fullname: Ishikura, Tomoyuki
  organization: Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
– sequence: 19
  givenname: Gundula
  surname: Streubel
  fullname: Streubel, Gundula
  organization: Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
– sequence: 20
  givenname: Kieran
  surname: Wynne
  fullname: Wynne, Kieran
  organization: Gene Regulation, Stem Cells and Cancer Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain
– sequence: 21
  givenname: Karsten
  surname: Hokamp
  fullname: Hokamp, Karsten
  organization: Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
– sequence: 22
  givenname: Aoife
  surname: McLysaght
  fullname: McLysaght, Aoife
  organization: Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
– sequence: 23
  givenname: Claudio
  surname: Ciferri
  fullname: Ciferri, Claudio
  organization: Chromosome Engineering Team, Department of Technology Development, Kazusa DNA Research Institute, Kisarazu 292-0818, Japan
– sequence: 24
  givenname: Luciano
  surname: Di Croce
  fullname: Di Croce, Luciano
  organization: Gene Regulation, Stem Cells and Cancer Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain
– sequence: 25
  givenname: Gerard
  surname: Cagney
  fullname: Cagney, Gerard
  organization: School of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland
– sequence: 26
  givenname: Raphaël
  surname: Margueron
  fullname: Margueron, Raphaël
  organization: Institut Curie, Paris Sciences et Lettres (PSL) Research University, CNRS UMR 3215, INSERM U934, 75248 Paris Cedex 05, France
– sequence: 27
  givenname: Haruhiko
  surname: Koseki
  fullname: Koseki, Haruhiko
  organization: Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
– sequence: 28
  givenname: Adrian P.
  surname: Bracken
  fullname: Bracken, Adrian P.
  email: adrian.bracken@tcd.ie
  organization: Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29628311$$D View this record in MEDLINE/PubMed
https://hal.science/hal-03951752$$DView record in HAL
BookMark eNp9kVtr3DAQhUVJaS7tPyhFj-2DHd0se18KmyWXgiEhafsqJHlMtNjWVtIu-N9Xi7d57MtoEN_MYc65RGeTnwChz5SUlFB5vS1HP1gYSkZoUxJeElK9QxeUrOpCUCnOTj2rZXWOLmPcEkJF1aw-oHO2kqzhlF4gt8Z3enTDjH2Pf0NIYIJOULzswLreWfzkh9n60UR8O1nfQYfNjNMr4Hbz-Hx9LC2-hwkivtGDnizgp-cNwy97k-Yd4LVN7uCSg_gRve_1EOHT6b1Cv-5uf24eivbx_sdm3Ra2Ik0quDayrzWThBAJTWcE1ZIYbg10ohGiqW1tqOFSdIJoIXglBFTQi5oJzU3Hr9C3Ze-rHtQuuFGHWXnt1MO6Vcc_wlcVrSt2oJn9urC74P_sISY1upg9zYeA30fFCOOCskbKjIoFtcHHGKB_202JOgaitmoJRB0DySoqB5LHvpwU9maE7m3oXwIZ-L4AkD05OAgqWgfZx84FsEl13v1f4S9fxp0Z
CitedBy_id crossref_primary_10_1016_j_molcel_2024_02_011
crossref_primary_10_1016_j_molmet_2024_101939
crossref_primary_10_1016_j_molcel_2019_12_001
crossref_primary_10_1021_acs_biochem_8b01064
crossref_primary_10_1186_s13072_022_00439_6
crossref_primary_10_1002_bies_201900249
crossref_primary_10_1038_s41388_021_01982_4
crossref_primary_10_1016_j_celrep_2022_110889
crossref_primary_10_1038_s41594_019_0197_y
crossref_primary_10_3390_cancers16122175
crossref_primary_10_3390_genes12101485
crossref_primary_10_1016_j_xplc_2021_100267
crossref_primary_10_1042_BST20200737
crossref_primary_10_1093_nar_gkad889
crossref_primary_10_3389_fcell_2022_986319
crossref_primary_10_1038_s41467_021_26203_0
crossref_primary_10_1146_annurev_biochem_120219_103641
crossref_primary_10_1016_j_gde_2023_102137
crossref_primary_10_1016_j_molcel_2019_08_012
crossref_primary_10_1016_j_molcel_2019_12_019
crossref_primary_10_1038_s42003_023_05501_x
crossref_primary_10_1016_j_tig_2020_12_006
crossref_primary_10_3390_epigenomes3020012
crossref_primary_10_1038_s41467_020_17878_y
crossref_primary_10_1016_j_canlet_2023_216143
crossref_primary_10_1016_j_molcel_2019_11_021
crossref_primary_10_1093_nar_gkac047
crossref_primary_10_1186_s12864_024_10090_y
crossref_primary_10_1101_gad_328773_119
crossref_primary_10_1038_s41467_019_11800_x
crossref_primary_10_3389_fcell_2024_1383200
crossref_primary_10_1126_sciadv_add0103
crossref_primary_10_1016_j_celrep_2024_113858
crossref_primary_10_1038_s41416_019_0615_2
crossref_primary_10_7554_eLife_51373
crossref_primary_10_1038_s41467_021_24866_3
crossref_primary_10_1038_s41401_019_0247_3
crossref_primary_10_3390_cells11071113
crossref_primary_10_1038_s12276_020_0462_5
crossref_primary_10_3390_ijms23179574
crossref_primary_10_1371_journal_pbio_3000221
crossref_primary_10_1038_s41419_019_1935_0
crossref_primary_10_1080_14728222_2019_1696309
crossref_primary_10_1016_j_stem_2019_03_005
crossref_primary_10_1080_15476286_2019_1565283
crossref_primary_10_1016_j_bbrc_2018_12_153
crossref_primary_10_1101_gad_326066_119
crossref_primary_10_1016_j_molcel_2019_03_011
crossref_primary_10_1042_BST20210450
crossref_primary_10_1371_journal_pone_0249406
crossref_primary_10_3390_epigenomes4030017
crossref_primary_10_1186_s13072_020_00369_1
crossref_primary_10_1038_s41580_021_00341_1
crossref_primary_10_1111_gtc_12634
crossref_primary_10_1210_clinem_dgac010
crossref_primary_10_1016_j_tcb_2019_05_004
crossref_primary_10_1016_j_molcel_2021_06_020
crossref_primary_10_1016_j_molcel_2019_03_024
crossref_primary_10_1016_j_jmb_2022_167936
crossref_primary_10_1042_BST20230336
crossref_primary_10_1002_bies_201900192
crossref_primary_10_1038_s41556_022_01056_x
crossref_primary_10_1038_s41580_021_00398_y
crossref_primary_10_1016_j_stemcr_2020_07_007
crossref_primary_10_1073_pnas_1814634116
crossref_primary_10_1016_j_imlet_2018_06_008
crossref_primary_10_3390_genes15050576
crossref_primary_10_1016_j_molcel_2023_03_018
crossref_primary_10_3390_epigenomes6030023
crossref_primary_10_1038_s41467_021_27314_4
crossref_primary_10_1016_j_molcel_2022_11_010
crossref_primary_10_5411_wji_v10_i1_1
crossref_primary_10_1038_s41467_019_09981_6
crossref_primary_10_1093_nar_gkab304
crossref_primary_10_1111_cpr_13413
crossref_primary_10_1242_dev_181354
crossref_primary_10_1002_ddr_21796
crossref_primary_10_1002_ajmg_c_31754
crossref_primary_10_1371_journal_pgen_1008681
crossref_primary_10_1038_s41467_022_34431_1
crossref_primary_10_1186_s12864_022_08694_3
crossref_primary_10_1242_dev_199628
crossref_primary_10_1016_j_gde_2020_02_023
crossref_primary_10_1016_j_jgg_2021_03_013
crossref_primary_10_1016_j_sbi_2020_10_017
crossref_primary_10_3390_genes14040938
crossref_primary_10_1002_bies_201800222
crossref_primary_10_3390_v13081470
crossref_primary_10_1371_journal_pone_0286861
crossref_primary_10_1021_acs_jmedchem_1c00226
crossref_primary_10_2139_ssrn_4089979
crossref_primary_10_1016_j_stemcr_2021_01_009
crossref_primary_10_1016_j_molcel_2021_03_038
crossref_primary_10_1093_nar_gkac290
crossref_primary_10_1042_BST20230426
crossref_primary_10_1016_j_molcel_2019_07_031
crossref_primary_10_1101_gad_325050_119
crossref_primary_10_1042_BST20200238
crossref_primary_10_5483_BMBRep_2022_55_12_174
crossref_primary_10_1093_narcan_zcab039
crossref_primary_10_1083_jcb_202311021
crossref_primary_10_1158_2767_9764_CRC_23_0013
Cites_doi 10.1093/emboj/cdg542
10.1016/j.molcel.2013.10.030
10.15252/embj.201696307
10.1038/nrm4067
10.1101/gad.225888.113
10.1101/gad.381706
10.1038/nature08788
10.1038/sj.emboj.7600402
10.1242/dev.122.5.1513
10.1101/gr.188920.114
10.1101/gad.415507
10.1186/1471-2164-15-284
10.1093/nar/gkv1157
10.1128/MCB.00107-17
10.1016/j.celrep.2016.08.096
10.1210/er.2002-0032
10.1172/JCI27987
10.1038/nbt.3519
10.1186/s13059-014-0550-8
10.1016/j.jhep.2011.07.014
10.1038/nature09784
10.1038/nprot.2016.095
10.1016/j.ceb.2015.10.003
10.1038/msb.2011.75
10.1016/j.celrep.2014.10.018
10.1242/dev.123935
10.1038/nbt.1511
10.1016/j.molcel.2016.10.018
10.1038/nature14248
10.1038/nsmb.2833
10.1074/jbc.M109.051201
10.1016/j.stem.2014.05.006
10.1073/pnas.1400648111
10.1093/nar/gkv397
10.1016/j.cell.2017.08.002
10.1016/S1097-2765(03)00014-5
10.1016/j.molcel.2004.06.020
10.1038/nature23881
10.12688/f1000research.7563.1
10.1101/gad.1886410
10.1038/sj.emboj.7601187
10.1186/1471-2164-14-206
10.1002/stem.578
10.1038/nmeth.1923
10.1016/j.tibs.2017.04.003
10.1038/ncomms13661
10.1016/j.devcel.2013.08.016
10.1126/science.aah5403
10.1101/gad.267930.115
10.1093/bioinformatics/bti541
10.1093/nar/gks941
10.1038/nsmb.2449
10.1016/j.molcel.2014.12.020
10.1016/j.celrep.2015.06.060
10.1093/nar/gkw257
10.1038/nprot.2012.101
10.1038/nsmb.3488
10.1186/1471-2105-10-421
10.1016/j.molcel.2008.11.004
10.1038/s41594-018-0036-6
10.1016/j.molcel.2016.10.019
10.1093/bioinformatics/btu033
10.1038/nrc.2016.83
10.1016/j.jmb.2016.12.001
ContentType Journal Article
Copyright 2018 Elsevier Inc.
Copyright © 2018 Elsevier Inc. All rights reserved.
Distributed under a Creative Commons Attribution 4.0 International License
Copyright_xml – notice: 2018 Elsevier Inc.
– notice: Copyright © 2018 Elsevier Inc. All rights reserved.
– notice: Distributed under a Creative Commons Attribution 4.0 International License
DBID 6I.
AAFTH
NPM
AAYXX
CITATION
7X8
1XC
DOI 10.1016/j.molcel.2018.03.005
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
PubMed
CrossRef
MEDLINE - Academic
Hyper Article en Ligne (HAL)
DatabaseTitle PubMed
CrossRef
MEDLINE - Academic
DatabaseTitleList
PubMed
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1097-4164
EndPage 421.e8
ExternalDocumentID oai_HAL_hal_03951752v1
10_1016_j_molcel_2018_03_005
29628311
S1097276518301862
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: Biotechnology and Biological Sciences Research Council
GroupedDBID ---
--K
-DZ
-~X
0R~
123
1~5
2WC
4.4
457
4G.
5RE
62-
6I.
7-5
AACTN
AAEDW
AAFTH
AAIAV
AAKRW
AAKUH
AALRI
AAUCE
AAVLU
AAXJY
AAXUO
ABJNI
ABMAC
ABMWF
ABVKL
ACGFO
ACGFS
ACNCT
ADBBV
ADEZE
ADJPV
AEFWE
AENEX
AEXQZ
AFFNX
AFTJW
AGKMS
AITUG
ALKID
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
ASPBG
AVWKF
AZFZN
BAWUL
CS3
DIK
DU5
E3Z
EBS
EJD
F5P
FCP
FDB
FEDTE
FIRID
HH5
HVGLF
IH2
IHE
IXB
J1W
JIG
KQ8
L7B
M3Z
M41
N9A
NCXOZ
O-L
O9-
OK1
P2P
RCE
RIG
ROL
RPZ
SDG
SES
SSZ
TR2
WQ6
ZA5
0SF
AAEDT
AAHBH
AAMRU
ADVLN
AKAPO
AKRWK
NPM
.55
.GJ
29M
3O-
53G
5VS
AAIKJ
AAQFI
AAQXK
AAYXX
ACRPL
ADMUD
ADNMO
AGHFR
CITATION
FGOYB
HZ~
OZT
R2-
UHS
X7M
ZGI
ZXP
7X8
1XC
ID FETCH-LOGICAL-c508t-3ab6f7a260006e8db41a60b3cbed484487c7b1b364d40a443544e5ef4724a3bd3
IEDL.DBID ABVKL
ISSN 1097-2765
IngestDate Thu Oct 31 07:32:07 EDT 2024
Sun Sep 29 07:41:31 EDT 2024
Fri Dec 06 03:24:22 EST 2024
Wed Oct 16 00:50:36 EDT 2024
Fri Feb 23 02:30:35 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 3
Keywords PRC2
AEBP2
PALI1
polycomb
LCOR
C10ORF12
H3K27me2
EZH2
H3K27me3
Language English
License This article is made available under the Elsevier license.
Copyright © 2018 Elsevier Inc. All rights reserved.
Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c508t-3ab6f7a260006e8db41a60b3cbed484487c7b1b364d40a443544e5ef4724a3bd3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0001-6399-0230
OpenAccessLink https://www.sciencedirect.com/science/article/pii/S1097276518301862
PMID 29628311
PQID 2023412866
PQPubID 23479
ParticipantIDs hal_primary_oai_HAL_hal_03951752v1
proquest_miscellaneous_2023412866
crossref_primary_10_1016_j_molcel_2018_03_005
pubmed_primary_29628311
elsevier_sciencedirect_doi_10_1016_j_molcel_2018_03_005
PublicationCentury 2000
PublicationDate 2018-05-03
PublicationDateYYYYMMDD 2018-05-03
PublicationDate_xml – month: 05
  year: 2018
  text: 2018-05-03
  day: 03
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Molecular cell
PublicationTitleAlternate Mol Cell
PublicationYear 2018
Publisher Elsevier Inc
Cell Press
Publisher_xml – name: Elsevier Inc
– name: Cell Press
References Finn, Clements, Arndt, Miller, Wheeler, Schreiber, Bateman, Eddy (bib23) 2015; 43
Schoeftner, Sengupta, Kubicek, Mechtler, Spahn, Koseki, Jenuwein, Wutz (bib50) 2006; 25
Smits, Jansen, Poser, Hyman, Vermeulen (bib55) 2013; 41
Brien, Healy, Jerman, Conway, Fadda, O’Donovan, Krivtsov, Rice, Kearney, Flaus (bib10) 2015; 29
Sievers, Wilm, Dineen, Gibson, Karplus, Li, Lopez, McWilliam, Remmert, Söding (bib54) 2011; 7
Choi, Bachmann, Tauscher, Benda, Fierz, Müller (bib13) 2017; 24
Mullin, Gagliardi, Khoa, Colby, Hall-Ponsele, Rowe, Chambers (bib42) 2017; 429
Zhang, Jones, Sun, Li, Chang, Joo, Dai, Mysliwiec, Wu, Guo (bib62) 2011; 29
Ramírez, Ryan, Grüning, Bhardwaj, Kilpert, Richter, Heyne, Dündar, Manke (bib48) 2016; 44
Streubel, Fitzpatrick, Oliviero, Scelfo, Moran, Das, Munawar, Watson, Wynne, Negri (bib60) 2017; 36
Hauri, Comoglio, Seimiya, Gerstung, Glatter, Hansen, Aebersold, Paro, Gstaiger, Beisel (bib25) 2016; 17
Shen, Shao, Liu, Nestler (bib53) 2014; 15
Lee, Kahn, Simcox, Schwartz, Pirrotta (bib35) 2015; 25
Beringer, Pisano, Di Carlo, Blanco, Chammas, Vizán, Gutiérrez, Aranda, Payer, Wierer, Di Croce (bib3) 2016; 64
Alekseyenko, Gorchakov, Kharchenko, Kuroda (bib2) 2014; 111
Shalom-Barak, Liersemann, Memari, Flechner, Devor, Bernardo, Kim, Matsumoto, Friedman, Evans (bib52) 2018
Cao, Zhang (bib12) 2004; 15
Cooper, Grijzenhout, Underwood, Ancelin, Zhang, Nesterova, Anil-Kirmizitas, Bassett, Kooistra, Agger (bib16) 2016; 7
Kundaje, Meuleman, Ernst, Bilenky, Yen, Heravi-Moussavi, Kheradpour, Zhang, Wang, Ziller (bib30) 2015; 518
Camacho, Coulouris, Avagyan, Ma, Papadopoulos, Bealer, Madden (bib11) 2009; 10
Bracken, Pasini, Capra, Prosperini, Colli, Helin (bib5) 2003; 22
Conway, Healy, Bracken (bib15) 2015; 37
Cox, Mann (bib17) 2008; 26
Li, Margueron, Ku, Chambon, Bernstein, Reinberg (bib36) 2010; 24
Stamatakis (bib59) 2014; 30
Akasaka, Kanno, Balling, Mieza, Taniguchi, Koseki (bib1) 1996; 122
Højfeldt, Laugesen, Willumsen, Damhofer, Hedehus, Tvardovskiy, Mohammad, Jensen, Helin (bib64) 2018; 25
Yates, Akanni, Amode, Barrell, Billis, Carvalho-Silva, Cummins, Clapham, Fitzgerald, Gil (bib61) 2016; 44
Comet, Riising, Leblanc, Helin (bib14) 2016; 16
Isono, Endo, Ku, Yamada, Suzuki, Sharif, Ishikura, Toyoda, Bernstein, Koseki (bib28) 2013; 26
Pasini, Bracken, Jensen, Lazzerini Denchi, Helin (bib45) 2004; 23
Sanulli, Justin, Teissandier, Ancelin, Portoso, Caron, Michaud, Lombard, da Rocha, Offer (bib49) 2015; 57
Li, Liefke, Jiang, Kurland, Tian, Deng, Zhang, He, Patel, Bulyk (bib37) 2017; 549
Deroo, Korach (bib18) 2006; 116
Love, Huber, Anders (bib39) 2014; 15
Zhu, Xiang, Chen, Chen, Yang (bib63) 2013; 14
Pasini, Cloos, Walfridsson, Olsson, Bukowski, Johansen, Bak, Tommerup, Rappsilber, Helin (bib46) 2010; 464
Landeira, Bagci, Malinowski, Brown, Soza-Ried, Feytout, Webster, Ndjetehe, Cantone, Asenjo (bib31) 2015; 12
Laugesen, Helin (bib34) 2014; 14
Schuettengruber, Bourbon, Di Croce, Cavalli (bib51) 2017; 171
Soneson, Love, Robinson (bib57) 2015; 4
Bracken, Kleine-Kohlbrecher, Dietrich, Pasini, Gargiulo, Beekman, Theilgaard-Mönch, Minucci, Porse, Marine (bib7) 2007; 21
Fernandes, Bastien, Wai, Nygard, Lin, Cormier, Lee, Eng, Bertos, Pelletier (bib21) 2003; 11
Liefke, Karwacki-Neisius, Shi (bib38) 2016; 64
Brien, Gambero, O’Connell, Jerman, Turner, Egan, Dunne, Jurgens, Wynne, Piao (bib9) 2012; 19
Son, Shen, Margueron, Reinberg (bib56) 2013; 27
Orlando, Chen, Brown, Solanki, Choi, Olson, Fritz, Bradner, Guenther (bib43) 2014; 9
Ferrari, Scelfo, Jammula, Cuomo, Barozzi, Stützer, Fischle, Bonaldi, Pasini (bib22) 2014; 53
Lau, Schwartz, Kundu, Savol, Wang, Marr, Grau, Schorderet, Sadreyev, Tabin, Kingston (bib33) 2017; 355
Holoch, Margueron (bib27) 2017; 42
Kalb, Latwiel, Baymaz, Jansen, Müller, Vermeulen, Müller (bib29) 2014; 21
Margueron, Reinberg (bib40) 2011; 469
Dosztányi, Csizmok, Tompa, Simon (bib19) 2005; 21
Bracken, Dietrich, Pasini, Hansen, Helin (bib6) 2006; 20
Feng, Liu, Qin, Zhang, Liu (bib20) 2012; 7
Margueron, Li, Sarma, Blais, Zavadil, Woodcock, Dynlacht, Reinberg (bib41) 2008; 32
Langmead, Salzberg (bib32) 2012; 9
Song, Shan, Zhang, Liu, Ding, Ren, Xia, Li, Zhang, Zhao (bib58) 2012; 56
Heinlein, Chang (bib26) 2004; 25
Palijan, Fernandes, Verway, Kourelis, Bastien, Tavera-Mendoza, Sacheli, Bourdeau, Mader, White (bib44) 2009; 284
Pertea, Kim, Pertea, Leek, Salzberg (bib47) 2016; 11
Blackledge, Rose, Klose (bib4) 2015; 16
Grijzenhout, Godwin, Koseki, Gdula, Szumska, McGouran, Bhattacharya, Kessler, Brockdorff, Cooper (bib24) 2016; 143
Bray, Pimentel, Melsted, Pachter (bib8) 2016; 34
Beringer (10.1016/j.molcel.2018.03.005_bib3) 2016; 64
Cox (10.1016/j.molcel.2018.03.005_bib17) 2008; 26
Comet (10.1016/j.molcel.2018.03.005_bib14) 2016; 16
Bray (10.1016/j.molcel.2018.03.005_bib8) 2016; 34
Kalb (10.1016/j.molcel.2018.03.005_bib29) 2014; 21
Landeira (10.1016/j.molcel.2018.03.005_bib31) 2015; 12
Pertea (10.1016/j.molcel.2018.03.005_bib47) 2016; 11
Mullin (10.1016/j.molcel.2018.03.005_bib42) 2017; 429
Shen (10.1016/j.molcel.2018.03.005_bib53) 2014; 15
Streubel (10.1016/j.molcel.2018.03.005_bib60) 2017; 36
Smits (10.1016/j.molcel.2018.03.005_bib55) 2013; 41
Palijan (10.1016/j.molcel.2018.03.005_bib44) 2009; 284
Finn (10.1016/j.molcel.2018.03.005_bib23) 2015; 43
Bracken (10.1016/j.molcel.2018.03.005_bib5) 2003; 22
Holoch (10.1016/j.molcel.2018.03.005_bib27) 2017; 42
Schoeftner (10.1016/j.molcel.2018.03.005_bib50) 2006; 25
Cao (10.1016/j.molcel.2018.03.005_bib12) 2004; 15
Ferrari (10.1016/j.molcel.2018.03.005_bib22) 2014; 53
Hauri (10.1016/j.molcel.2018.03.005_bib25) 2016; 17
Margueron (10.1016/j.molcel.2018.03.005_bib41) 2008; 32
Li (10.1016/j.molcel.2018.03.005_bib36) 2010; 24
Song (10.1016/j.molcel.2018.03.005_bib58) 2012; 56
Bracken (10.1016/j.molcel.2018.03.005_bib7) 2007; 21
Son (10.1016/j.molcel.2018.03.005_bib56) 2013; 27
Stamatakis (10.1016/j.molcel.2018.03.005_bib59) 2014; 30
Laugesen (10.1016/j.molcel.2018.03.005_bib34) 2014; 14
Ramírez (10.1016/j.molcel.2018.03.005_bib48) 2016; 44
Højfeldt (10.1016/j.molcel.2018.03.005_bib64) 2018; 25
Brien (10.1016/j.molcel.2018.03.005_bib9) 2012; 19
Margueron (10.1016/j.molcel.2018.03.005_bib40) 2011; 469
Lau (10.1016/j.molcel.2018.03.005_bib33) 2017; 355
Zhang (10.1016/j.molcel.2018.03.005_bib62) 2011; 29
Pasini (10.1016/j.molcel.2018.03.005_bib46) 2010; 464
Heinlein (10.1016/j.molcel.2018.03.005_bib26) 2004; 25
Pasini (10.1016/j.molcel.2018.03.005_bib45) 2004; 23
Deroo (10.1016/j.molcel.2018.03.005_bib18) 2006; 116
Sievers (10.1016/j.molcel.2018.03.005_bib54) 2011; 7
Cooper (10.1016/j.molcel.2018.03.005_bib16) 2016; 7
Kundaje (10.1016/j.molcel.2018.03.005_bib30) 2015; 518
Fernandes (10.1016/j.molcel.2018.03.005_bib21) 2003; 11
Choi (10.1016/j.molcel.2018.03.005_bib13) 2017; 24
Camacho (10.1016/j.molcel.2018.03.005_bib11) 2009; 10
Liefke (10.1016/j.molcel.2018.03.005_bib38) 2016; 64
Zhu (10.1016/j.molcel.2018.03.005_bib63) 2013; 14
Akasaka (10.1016/j.molcel.2018.03.005_bib1) 1996; 122
Love (10.1016/j.molcel.2018.03.005_bib39) 2014; 15
Conway (10.1016/j.molcel.2018.03.005_bib15) 2015; 37
Yates (10.1016/j.molcel.2018.03.005_bib61) 2016; 44
Lee (10.1016/j.molcel.2018.03.005_bib35) 2015; 25
Alekseyenko (10.1016/j.molcel.2018.03.005_bib2) 2014; 111
Soneson (10.1016/j.molcel.2018.03.005_bib57) 2015; 4
Langmead (10.1016/j.molcel.2018.03.005_bib32) 2012; 9
Li (10.1016/j.molcel.2018.03.005_bib37) 2017; 549
Sanulli (10.1016/j.molcel.2018.03.005_bib49) 2015; 57
Shalom-Barak (10.1016/j.molcel.2018.03.005_bib52) 2018
Grijzenhout (10.1016/j.molcel.2018.03.005_bib24) 2016; 143
Orlando (10.1016/j.molcel.2018.03.005_bib43) 2014; 9
Feng (10.1016/j.molcel.2018.03.005_bib20) 2012; 7
Brien (10.1016/j.molcel.2018.03.005_bib10) 2015; 29
Schuettengruber (10.1016/j.molcel.2018.03.005_bib51) 2017; 171
Dosztányi (10.1016/j.molcel.2018.03.005_bib19) 2005; 21
Isono (10.1016/j.molcel.2018.03.005_bib28) 2013; 26
Blackledge (10.1016/j.molcel.2018.03.005_bib4) 2015; 16
Bracken (10.1016/j.molcel.2018.03.005_bib6) 2006; 20
References_xml – volume: 64
  start-page: 645
  year: 2016
  end-page: 658
  ident: bib3
  article-title: EPOP functionally links elongin and polycomb in pluripotent stem cells
  publication-title: Mol. Cell
  contributor:
    fullname: Di Croce
– volume: 23
  start-page: 4061
  year: 2004
  end-page: 4071
  ident: bib45
  article-title: Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
  publication-title: EMBO J.
  contributor:
    fullname: Helin
– volume: 464
  start-page: 306
  year: 2010
  end-page: 310
  ident: bib46
  article-title: JARID2 regulates binding of the polycomb repressive complex 2 to target genes in ES cells
  publication-title: Nature
  contributor:
    fullname: Helin
– volume: 24
  start-page: 1039
  year: 2017
  end-page: 1047
  ident: bib13
  article-title: DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation
  publication-title: Nat. Struct. Mol. Biol.
  contributor:
    fullname: Müller
– volume: 34
  start-page: 525
  year: 2016
  end-page: 527
  ident: bib8
  article-title: Near-optimal probabilistic RNA-seq quantification
  publication-title: Nat. Biotechnol.
  contributor:
    fullname: Pachter
– volume: 25
  start-page: 225
  year: 2018
  end-page: 232
  ident: bib64
  article-title: Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2
  publication-title: Nat. Struct. Mol. Biol.
  contributor:
    fullname: Helin
– volume: 42
  start-page: 531
  year: 2017
  end-page: 542
  ident: bib27
  article-title: Mechanisms regulating PRC2 recruitment and enzymatic activity
  publication-title: Trends Biochem. Sci.
  contributor:
    fullname: Margueron
– volume: 15
  start-page: 550
  year: 2014
  ident: bib39
  article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
  publication-title: Genome Biol.
  contributor:
    fullname: Anders
– volume: 25
  start-page: 3110
  year: 2006
  end-page: 3122
  ident: bib50
  article-title: Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing
  publication-title: EMBO J.
  contributor:
    fullname: Wutz
– volume: 143
  start-page: 2716
  year: 2016
  end-page: 2723
  ident: bib24
  article-title: Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs
  publication-title: Development
  contributor:
    fullname: Cooper
– volume: 429
  start-page: 1544
  year: 2017
  end-page: 1553
  ident: bib42
  article-title: Distinct contributions of tryptophan residues within the dimerization domain to Nanog function
  publication-title: J. Mol. Biol.
  contributor:
    fullname: Chambers
– volume: 171
  start-page: 34
  year: 2017
  end-page: 57
  ident: bib51
  article-title: Genome regulation by polycomb and Trithorax: 70 years and counting
  publication-title: Cell
  contributor:
    fullname: Cavalli
– volume: 56
  start-page: 248
  year: 2012
  end-page: 254
  ident: bib58
  article-title: Ligand-dependent corepressor acts as a novel corepressor of thyroid hormone receptor and represses hepatic lipogenesis in mice
  publication-title: J. Hepatol.
  contributor:
    fullname: Zhao
– volume: 21
  start-page: 569
  year: 2014
  end-page: 571
  ident: bib29
  article-title: Histone H2A monoubiquitination promotes histone H3 methylation in polycomb repression
  publication-title: Nat. Struct. Mol. Biol.
  contributor:
    fullname: Müller
– volume: 25
  start-page: 1170
  year: 2015
  end-page: 1181
  ident: bib35
  article-title: Genome-wide activities of Polycomb complexes control pervasive transcription
  publication-title: Genome Res.
  contributor:
    fullname: Pirrotta
– volume: 116
  start-page: 561
  year: 2006
  end-page: 570
  ident: bib18
  article-title: Estrogen receptors and human disease
  publication-title: J. Clin. Invest.
  contributor:
    fullname: Korach
– volume: 11
  start-page: 139
  year: 2003
  end-page: 150
  ident: bib21
  article-title: Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms
  publication-title: Mol. Cell
  contributor:
    fullname: Pelletier
– volume: 4
  start-page: 1521
  year: 2015
  ident: bib57
  article-title: Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences
  publication-title: F1000Res.
  contributor:
    fullname: Robinson
– volume: 44
  start-page: W160
  year: 2016
  end-page: W165
  ident: bib48
  article-title: deepTools2: a next generation web server for deep-sequencing data analysis
  publication-title: Nucleic Acids Res.
  contributor:
    fullname: Manke
– volume: 14
  start-page: 735
  year: 2014
  end-page: 751
  ident: bib34
  article-title: Chromatin repressive complexes in stem cells, development, and cancer
  publication-title: Cell Stem Cell
  contributor:
    fullname: Helin
– volume: 19
  start-page: 1273
  year: 2012
  end-page: 1281
  ident: bib9
  article-title: Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation
  publication-title: Nat. Struct. Mol. Biol.
  contributor:
    fullname: Piao
– volume: 32
  start-page: 503
  year: 2008
  end-page: 518
  ident: bib41
  article-title: Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms
  publication-title: Mol. Cell
  contributor:
    fullname: Reinberg
– volume: 43
  start-page: W30
  year: 2015
  end-page: W38
  ident: bib23
  article-title: HMMER web server: 2015 update
  publication-title: Nucleic Acids Res.
  contributor:
    fullname: Eddy
– volume: 22
  start-page: 5323
  year: 2003
  end-page: 5335
  ident: bib5
  article-title: EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
  publication-title: EMBO J.
  contributor:
    fullname: Helin
– volume: 26
  start-page: 565
  year: 2013
  end-page: 577
  ident: bib28
  article-title: SAM domain polymerization links subnuclear clustering of PRC1 to gene silencing
  publication-title: Dev. Cell
  contributor:
    fullname: Koseki
– volume: 36
  start-page: 2216
  year: 2017
  end-page: 2232
  ident: bib60
  article-title: Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal
  publication-title: EMBO J.
  contributor:
    fullname: Negri
– volume: 26
  start-page: 1367
  year: 2008
  end-page: 1372
  ident: bib17
  article-title: MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
  publication-title: Nat. Biotechnol.
  contributor:
    fullname: Mann
– year: 2018
  ident: bib52
  article-title: Ligand-dependent corepressor (LCoR) is a rexinoid-inhibited PPARγ-RXRα coactivator
  publication-title: Mol. Cell. Biol.
  contributor:
    fullname: Evans
– volume: 7
  start-page: 539
  year: 2011
  ident: bib54
  article-title: Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega
  publication-title: Mol. Syst. Biol.
  contributor:
    fullname: Söding
– volume: 41
  start-page: e28
  year: 2013
  ident: bib55
  article-title: Stoichiometry of chromatin-associated protein complexes revealed by label-free quantitative mass spectrometry-based proteomics
  publication-title: Nucleic Acids Res.
  contributor:
    fullname: Vermeulen
– volume: 111
  start-page: 2488
  year: 2014
  end-page: 2493
  ident: bib2
  article-title: Reciprocal interactions of human C10orf12 and C17orf96 with PRC2 revealed by BioTAP-XL cross-linking and affinity purification
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Kuroda
– volume: 37
  start-page: 42
  year: 2015
  end-page: 48
  ident: bib15
  article-title: PRC2 mediated H3K27 methylations in cellular identity and cancer
  publication-title: Curr. Opin. Cell Biol.
  contributor:
    fullname: Bracken
– volume: 7
  start-page: 13661
  year: 2016
  ident: bib16
  article-title: Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2
  publication-title: Nat. Commun.
  contributor:
    fullname: Agger
– volume: 16
  start-page: 643
  year: 2015
  end-page: 649
  ident: bib4
  article-title: Targeting polycomb systems to regulate gene expression: modifications to a complex story
  publication-title: Nat. Rev. Mol. Cell Biol.
  contributor:
    fullname: Klose
– volume: 469
  start-page: 343
  year: 2011
  end-page: 349
  ident: bib40
  article-title: The polycomb complex PRC2 and its mark in life
  publication-title: Nature
  contributor:
    fullname: Reinberg
– volume: 27
  start-page: 2663
  year: 2013
  end-page: 2677
  ident: bib56
  article-title: Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin
  publication-title: Genes Dev.
  contributor:
    fullname: Reinberg
– volume: 549
  start-page: 287
  year: 2017
  end-page: 291
  ident: bib37
  article-title: Polycomb-like proteins link the PRC2 complex to CpG islands
  publication-title: Nature
  contributor:
    fullname: Bulyk
– volume: 20
  start-page: 1123
  year: 2006
  end-page: 1136
  ident: bib6
  article-title: Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
  publication-title: Genes Dev.
  contributor:
    fullname: Helin
– volume: 21
  start-page: 525
  year: 2007
  end-page: 530
  ident: bib7
  article-title: The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
  publication-title: Genes Dev.
  contributor:
    fullname: Marine
– volume: 15
  start-page: 57
  year: 2004
  end-page: 67
  ident: bib12
  article-title: SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex
  publication-title: Mol. Cell
  contributor:
    fullname: Zhang
– volume: 355
  start-page: 1081
  year: 2017
  end-page: 1084
  ident: bib33
  article-title: Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning
  publication-title: Science
  contributor:
    fullname: Kingston
– volume: 29
  start-page: 229
  year: 2011
  end-page: 240
  ident: bib62
  article-title: PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming
  publication-title: Stem Cells
  contributor:
    fullname: Guo
– volume: 10
  start-page: 421
  year: 2009
  ident: bib11
  article-title: BLAST+: architecture and applications
  publication-title: BMC Bioinformatics
  contributor:
    fullname: Madden
– volume: 284
  start-page: 30275
  year: 2009
  end-page: 30287
  ident: bib44
  article-title: Ligand-dependent corepressor LCoR is an attenuator of progesterone-regulated gene expression
  publication-title: J. Biol. Chem.
  contributor:
    fullname: White
– volume: 12
  start-page: 573
  year: 2015
  end-page: 586
  ident: bib31
  article-title: Jarid2 coordinates Nanog expression and PCP/Wnt signaling required for efficient ESC differentiation and early embryo development
  publication-title: Cell Rep.
  contributor:
    fullname: Asenjo
– volume: 64
  start-page: 659
  year: 2016
  end-page: 672
  ident: bib38
  article-title: EPOP interacts with elongin BC and USP7 to modulate the chromatin landscape
  publication-title: Mol. Cell
  contributor:
    fullname: Shi
– volume: 24
  start-page: 368
  year: 2010
  end-page: 380
  ident: bib36
  article-title: Jarid2 and PRC2, partners in regulating gene expression
  publication-title: Genes Dev.
  contributor:
    fullname: Reinberg
– volume: 122
  start-page: 1513
  year: 1996
  end-page: 1522
  ident: bib1
  article-title: A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton
  publication-title: Development
  contributor:
    fullname: Koseki
– volume: 44
  start-page: D710
  year: 2016
  end-page: D716
  ident: bib61
  article-title: Ensembl 2016
  publication-title: Nucleic Acids Res.
  contributor:
    fullname: Gil
– volume: 30
  start-page: 1312
  year: 2014
  end-page: 1313
  ident: bib59
  article-title: RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies
  publication-title: Bioinformatics
  contributor:
    fullname: Stamatakis
– volume: 14
  start-page: 206
  year: 2013
  ident: bib63
  article-title: Prediction of constitutive A-to-I editing sites from human transcriptomes in the absence of genomic sequences
  publication-title: BMC Genomics
  contributor:
    fullname: Yang
– volume: 29
  start-page: 2231
  year: 2015
  end-page: 2243
  ident: bib10
  article-title: A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence
  publication-title: Genes Dev.
  contributor:
    fullname: Flaus
– volume: 9
  start-page: 357
  year: 2012
  end-page: 359
  ident: bib32
  article-title: Fast gapped-read alignment with Bowtie 2
  publication-title: Nat. Methods
  contributor:
    fullname: Salzberg
– volume: 17
  start-page: 583
  year: 2016
  end-page: 595
  ident: bib25
  article-title: A high-density map for navigating the human polycomb complexome
  publication-title: Cell Rep.
  contributor:
    fullname: Beisel
– volume: 15
  start-page: 284
  year: 2014
  ident: bib53
  article-title: ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases
  publication-title: BMC Genomics
  contributor:
    fullname: Nestler
– volume: 53
  start-page: 49
  year: 2014
  end-page: 62
  ident: bib22
  article-title: Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity
  publication-title: Mol. Cell
  contributor:
    fullname: Pasini
– volume: 16
  start-page: 803
  year: 2016
  end-page: 810
  ident: bib14
  article-title: Maintaining cell identity: PRC2-mediated regulation of transcription and cancer
  publication-title: Nat. Rev. Cancer
  contributor:
    fullname: Helin
– volume: 9
  start-page: 1163
  year: 2014
  end-page: 1170
  ident: bib43
  article-title: Quantitative ChIP-seq normalization reveals global modulation of the epigenome
  publication-title: Cell Rep.
  contributor:
    fullname: Guenther
– volume: 518
  start-page: 317
  year: 2015
  end-page: 330
  ident: bib30
  article-title: Integrative analysis of 111 reference human epigenomes
  publication-title: Nature
  contributor:
    fullname: Ziller
– volume: 57
  start-page: 769
  year: 2015
  end-page: 783
  ident: bib49
  article-title: Jarid2 methylation via the PRC2 complex regulates H3K27me3 deposition during cell differentiation
  publication-title: Mol. Cell
  contributor:
    fullname: Offer
– volume: 21
  start-page: 3433
  year: 2005
  end-page: 3434
  ident: bib19
  article-title: IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content
  publication-title: Bioinformatics
  contributor:
    fullname: Simon
– volume: 25
  start-page: 276
  year: 2004
  end-page: 308
  ident: bib26
  article-title: Androgen receptor in prostate cancer
  publication-title: Endocr. Rev.
  contributor:
    fullname: Chang
– volume: 7
  start-page: 1728
  year: 2012
  end-page: 1740
  ident: bib20
  article-title: Identifying ChIP-seq enrichment using MACS
  publication-title: Nat. Protoc.
  contributor:
    fullname: Liu
– volume: 11
  start-page: 1650
  year: 2016
  end-page: 1667
  ident: bib47
  article-title: Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown
  publication-title: Nat. Protoc.
  contributor:
    fullname: Salzberg
– volume: 22
  start-page: 5323
  year: 2003
  ident: 10.1016/j.molcel.2018.03.005_bib5
  article-title: EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
  publication-title: EMBO J.
  doi: 10.1093/emboj/cdg542
  contributor:
    fullname: Bracken
– volume: 53
  start-page: 49
  year: 2014
  ident: 10.1016/j.molcel.2018.03.005_bib22
  article-title: Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2013.10.030
  contributor:
    fullname: Ferrari
– volume: 36
  start-page: 2216
  year: 2017
  ident: 10.1016/j.molcel.2018.03.005_bib60
  article-title: Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal
  publication-title: EMBO J.
  doi: 10.15252/embj.201696307
  contributor:
    fullname: Streubel
– volume: 16
  start-page: 643
  year: 2015
  ident: 10.1016/j.molcel.2018.03.005_bib4
  article-title: Targeting polycomb systems to regulate gene expression: modifications to a complex story
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm4067
  contributor:
    fullname: Blackledge
– volume: 27
  start-page: 2663
  year: 2013
  ident: 10.1016/j.molcel.2018.03.005_bib56
  article-title: Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin
  publication-title: Genes Dev.
  doi: 10.1101/gad.225888.113
  contributor:
    fullname: Son
– volume: 20
  start-page: 1123
  year: 2006
  ident: 10.1016/j.molcel.2018.03.005_bib6
  article-title: Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
  publication-title: Genes Dev.
  doi: 10.1101/gad.381706
  contributor:
    fullname: Bracken
– volume: 464
  start-page: 306
  year: 2010
  ident: 10.1016/j.molcel.2018.03.005_bib46
  article-title: JARID2 regulates binding of the polycomb repressive complex 2 to target genes in ES cells
  publication-title: Nature
  doi: 10.1038/nature08788
  contributor:
    fullname: Pasini
– volume: 23
  start-page: 4061
  year: 2004
  ident: 10.1016/j.molcel.2018.03.005_bib45
  article-title: Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7600402
  contributor:
    fullname: Pasini
– volume: 122
  start-page: 1513
  year: 1996
  ident: 10.1016/j.molcel.2018.03.005_bib1
  article-title: A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton
  publication-title: Development
  doi: 10.1242/dev.122.5.1513
  contributor:
    fullname: Akasaka
– volume: 25
  start-page: 1170
  year: 2015
  ident: 10.1016/j.molcel.2018.03.005_bib35
  article-title: Genome-wide activities of Polycomb complexes control pervasive transcription
  publication-title: Genome Res.
  doi: 10.1101/gr.188920.114
  contributor:
    fullname: Lee
– volume: 21
  start-page: 525
  year: 2007
  ident: 10.1016/j.molcel.2018.03.005_bib7
  article-title: The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
  publication-title: Genes Dev.
  doi: 10.1101/gad.415507
  contributor:
    fullname: Bracken
– volume: 15
  start-page: 284
  year: 2014
  ident: 10.1016/j.molcel.2018.03.005_bib53
  article-title: ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-15-284
  contributor:
    fullname: Shen
– volume: 44
  start-page: D710
  issue: D1
  year: 2016
  ident: 10.1016/j.molcel.2018.03.005_bib61
  article-title: Ensembl 2016
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv1157
  contributor:
    fullname: Yates
– year: 2018
  ident: 10.1016/j.molcel.2018.03.005_bib52
  article-title: Ligand-dependent corepressor (LCoR) is a rexinoid-inhibited PPARγ-RXRα coactivator
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.00107-17
  contributor:
    fullname: Shalom-Barak
– volume: 17
  start-page: 583
  year: 2016
  ident: 10.1016/j.molcel.2018.03.005_bib25
  article-title: A high-density map for navigating the human polycomb complexome
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.08.096
  contributor:
    fullname: Hauri
– volume: 25
  start-page: 276
  year: 2004
  ident: 10.1016/j.molcel.2018.03.005_bib26
  article-title: Androgen receptor in prostate cancer
  publication-title: Endocr. Rev.
  doi: 10.1210/er.2002-0032
  contributor:
    fullname: Heinlein
– volume: 116
  start-page: 561
  year: 2006
  ident: 10.1016/j.molcel.2018.03.005_bib18
  article-title: Estrogen receptors and human disease
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI27987
  contributor:
    fullname: Deroo
– volume: 34
  start-page: 525
  year: 2016
  ident: 10.1016/j.molcel.2018.03.005_bib8
  article-title: Near-optimal probabilistic RNA-seq quantification
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.3519
  contributor:
    fullname: Bray
– volume: 15
  start-page: 550
  year: 2014
  ident: 10.1016/j.molcel.2018.03.005_bib39
  article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0550-8
  contributor:
    fullname: Love
– volume: 56
  start-page: 248
  year: 2012
  ident: 10.1016/j.molcel.2018.03.005_bib58
  article-title: Ligand-dependent corepressor acts as a novel corepressor of thyroid hormone receptor and represses hepatic lipogenesis in mice
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2011.07.014
  contributor:
    fullname: Song
– volume: 469
  start-page: 343
  year: 2011
  ident: 10.1016/j.molcel.2018.03.005_bib40
  article-title: The polycomb complex PRC2 and its mark in life
  publication-title: Nature
  doi: 10.1038/nature09784
  contributor:
    fullname: Margueron
– volume: 11
  start-page: 1650
  year: 2016
  ident: 10.1016/j.molcel.2018.03.005_bib47
  article-title: Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2016.095
  contributor:
    fullname: Pertea
– volume: 37
  start-page: 42
  year: 2015
  ident: 10.1016/j.molcel.2018.03.005_bib15
  article-title: PRC2 mediated H3K27 methylations in cellular identity and cancer
  publication-title: Curr. Opin. Cell Biol.
  doi: 10.1016/j.ceb.2015.10.003
  contributor:
    fullname: Conway
– volume: 7
  start-page: 539
  year: 2011
  ident: 10.1016/j.molcel.2018.03.005_bib54
  article-title: Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega
  publication-title: Mol. Syst. Biol.
  doi: 10.1038/msb.2011.75
  contributor:
    fullname: Sievers
– volume: 9
  start-page: 1163
  year: 2014
  ident: 10.1016/j.molcel.2018.03.005_bib43
  article-title: Quantitative ChIP-seq normalization reveals global modulation of the epigenome
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.10.018
  contributor:
    fullname: Orlando
– volume: 143
  start-page: 2716
  year: 2016
  ident: 10.1016/j.molcel.2018.03.005_bib24
  article-title: Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs
  publication-title: Development
  doi: 10.1242/dev.123935
  contributor:
    fullname: Grijzenhout
– volume: 26
  start-page: 1367
  year: 2008
  ident: 10.1016/j.molcel.2018.03.005_bib17
  article-title: MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1511
  contributor:
    fullname: Cox
– volume: 64
  start-page: 645
  year: 2016
  ident: 10.1016/j.molcel.2018.03.005_bib3
  article-title: EPOP functionally links elongin and polycomb in pluripotent stem cells
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2016.10.018
  contributor:
    fullname: Beringer
– volume: 518
  start-page: 317
  year: 2015
  ident: 10.1016/j.molcel.2018.03.005_bib30
  article-title: Integrative analysis of 111 reference human epigenomes
  publication-title: Nature
  doi: 10.1038/nature14248
  contributor:
    fullname: Kundaje
– volume: 21
  start-page: 569
  year: 2014
  ident: 10.1016/j.molcel.2018.03.005_bib29
  article-title: Histone H2A monoubiquitination promotes histone H3 methylation in polycomb repression
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.2833
  contributor:
    fullname: Kalb
– volume: 284
  start-page: 30275
  year: 2009
  ident: 10.1016/j.molcel.2018.03.005_bib44
  article-title: Ligand-dependent corepressor LCoR is an attenuator of progesterone-regulated gene expression
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M109.051201
  contributor:
    fullname: Palijan
– volume: 14
  start-page: 735
  year: 2014
  ident: 10.1016/j.molcel.2018.03.005_bib34
  article-title: Chromatin repressive complexes in stem cells, development, and cancer
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2014.05.006
  contributor:
    fullname: Laugesen
– volume: 111
  start-page: 2488
  year: 2014
  ident: 10.1016/j.molcel.2018.03.005_bib2
  article-title: Reciprocal interactions of human C10orf12 and C17orf96 with PRC2 revealed by BioTAP-XL cross-linking and affinity purification
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1400648111
  contributor:
    fullname: Alekseyenko
– volume: 43
  start-page: W30
  issue: W1
  year: 2015
  ident: 10.1016/j.molcel.2018.03.005_bib23
  article-title: HMMER web server: 2015 update
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv397
  contributor:
    fullname: Finn
– volume: 171
  start-page: 34
  year: 2017
  ident: 10.1016/j.molcel.2018.03.005_bib51
  article-title: Genome regulation by polycomb and Trithorax: 70 years and counting
  publication-title: Cell
  doi: 10.1016/j.cell.2017.08.002
  contributor:
    fullname: Schuettengruber
– volume: 11
  start-page: 139
  year: 2003
  ident: 10.1016/j.molcel.2018.03.005_bib21
  article-title: Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms
  publication-title: Mol. Cell
  doi: 10.1016/S1097-2765(03)00014-5
  contributor:
    fullname: Fernandes
– volume: 15
  start-page: 57
  year: 2004
  ident: 10.1016/j.molcel.2018.03.005_bib12
  article-title: SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2004.06.020
  contributor:
    fullname: Cao
– volume: 549
  start-page: 287
  year: 2017
  ident: 10.1016/j.molcel.2018.03.005_bib37
  article-title: Polycomb-like proteins link the PRC2 complex to CpG islands
  publication-title: Nature
  doi: 10.1038/nature23881
  contributor:
    fullname: Li
– volume: 4
  start-page: 1521
  year: 2015
  ident: 10.1016/j.molcel.2018.03.005_bib57
  article-title: Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences
  publication-title: F1000Res.
  doi: 10.12688/f1000research.7563.1
  contributor:
    fullname: Soneson
– volume: 24
  start-page: 368
  year: 2010
  ident: 10.1016/j.molcel.2018.03.005_bib36
  article-title: Jarid2 and PRC2, partners in regulating gene expression
  publication-title: Genes Dev.
  doi: 10.1101/gad.1886410
  contributor:
    fullname: Li
– volume: 25
  start-page: 3110
  year: 2006
  ident: 10.1016/j.molcel.2018.03.005_bib50
  article-title: Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7601187
  contributor:
    fullname: Schoeftner
– volume: 14
  start-page: 206
  year: 2013
  ident: 10.1016/j.molcel.2018.03.005_bib63
  article-title: Prediction of constitutive A-to-I editing sites from human transcriptomes in the absence of genomic sequences
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-14-206
  contributor:
    fullname: Zhu
– volume: 29
  start-page: 229
  year: 2011
  ident: 10.1016/j.molcel.2018.03.005_bib62
  article-title: PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming
  publication-title: Stem Cells
  doi: 10.1002/stem.578
  contributor:
    fullname: Zhang
– volume: 9
  start-page: 357
  year: 2012
  ident: 10.1016/j.molcel.2018.03.005_bib32
  article-title: Fast gapped-read alignment with Bowtie 2
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1923
  contributor:
    fullname: Langmead
– volume: 42
  start-page: 531
  year: 2017
  ident: 10.1016/j.molcel.2018.03.005_bib27
  article-title: Mechanisms regulating PRC2 recruitment and enzymatic activity
  publication-title: Trends Biochem. Sci.
  doi: 10.1016/j.tibs.2017.04.003
  contributor:
    fullname: Holoch
– volume: 7
  start-page: 13661
  year: 2016
  ident: 10.1016/j.molcel.2018.03.005_bib16
  article-title: Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms13661
  contributor:
    fullname: Cooper
– volume: 26
  start-page: 565
  year: 2013
  ident: 10.1016/j.molcel.2018.03.005_bib28
  article-title: SAM domain polymerization links subnuclear clustering of PRC1 to gene silencing
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2013.08.016
  contributor:
    fullname: Isono
– volume: 355
  start-page: 1081
  year: 2017
  ident: 10.1016/j.molcel.2018.03.005_bib33
  article-title: Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning
  publication-title: Science
  doi: 10.1126/science.aah5403
  contributor:
    fullname: Lau
– volume: 29
  start-page: 2231
  year: 2015
  ident: 10.1016/j.molcel.2018.03.005_bib10
  article-title: A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence
  publication-title: Genes Dev.
  doi: 10.1101/gad.267930.115
  contributor:
    fullname: Brien
– volume: 21
  start-page: 3433
  year: 2005
  ident: 10.1016/j.molcel.2018.03.005_bib19
  article-title: IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bti541
  contributor:
    fullname: Dosztányi
– volume: 41
  start-page: e28
  year: 2013
  ident: 10.1016/j.molcel.2018.03.005_bib55
  article-title: Stoichiometry of chromatin-associated protein complexes revealed by label-free quantitative mass spectrometry-based proteomics
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gks941
  contributor:
    fullname: Smits
– volume: 19
  start-page: 1273
  year: 2012
  ident: 10.1016/j.molcel.2018.03.005_bib9
  article-title: Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.2449
  contributor:
    fullname: Brien
– volume: 57
  start-page: 769
  year: 2015
  ident: 10.1016/j.molcel.2018.03.005_bib49
  article-title: Jarid2 methylation via the PRC2 complex regulates H3K27me3 deposition during cell differentiation
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2014.12.020
  contributor:
    fullname: Sanulli
– volume: 12
  start-page: 573
  year: 2015
  ident: 10.1016/j.molcel.2018.03.005_bib31
  article-title: Jarid2 coordinates Nanog expression and PCP/Wnt signaling required for efficient ESC differentiation and early embryo development
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2015.06.060
  contributor:
    fullname: Landeira
– volume: 44
  start-page: W160
  issue: W1
  year: 2016
  ident: 10.1016/j.molcel.2018.03.005_bib48
  article-title: deepTools2: a next generation web server for deep-sequencing data analysis
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkw257
  contributor:
    fullname: Ramírez
– volume: 7
  start-page: 1728
  year: 2012
  ident: 10.1016/j.molcel.2018.03.005_bib20
  article-title: Identifying ChIP-seq enrichment using MACS
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2012.101
  contributor:
    fullname: Feng
– volume: 24
  start-page: 1039
  year: 2017
  ident: 10.1016/j.molcel.2018.03.005_bib13
  article-title: DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.3488
  contributor:
    fullname: Choi
– volume: 10
  start-page: 421
  year: 2009
  ident: 10.1016/j.molcel.2018.03.005_bib11
  article-title: BLAST+: architecture and applications
  publication-title: BMC Bioinformatics
  doi: 10.1186/1471-2105-10-421
  contributor:
    fullname: Camacho
– volume: 32
  start-page: 503
  year: 2008
  ident: 10.1016/j.molcel.2018.03.005_bib41
  article-title: Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2008.11.004
  contributor:
    fullname: Margueron
– volume: 25
  start-page: 225
  year: 2018
  ident: 10.1016/j.molcel.2018.03.005_bib64
  article-title: Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/s41594-018-0036-6
  contributor:
    fullname: Højfeldt
– volume: 64
  start-page: 659
  year: 2016
  ident: 10.1016/j.molcel.2018.03.005_bib38
  article-title: EPOP interacts with elongin BC and USP7 to modulate the chromatin landscape
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2016.10.019
  contributor:
    fullname: Liefke
– volume: 30
  start-page: 1312
  year: 2014
  ident: 10.1016/j.molcel.2018.03.005_bib59
  article-title: RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu033
  contributor:
    fullname: Stamatakis
– volume: 16
  start-page: 803
  year: 2016
  ident: 10.1016/j.molcel.2018.03.005_bib14
  article-title: Maintaining cell identity: PRC2-mediated regulation of transcription and cancer
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc.2016.83
  contributor:
    fullname: Comet
– volume: 429
  start-page: 1544
  year: 2017
  ident: 10.1016/j.molcel.2018.03.005_bib42
  article-title: Distinct contributions of tryptophan residues within the dimerization domain to Nanog function
  publication-title: J. Mol. Biol.
  doi: 10.1016/j.jmb.2016.12.001
  contributor:
    fullname: Mullin
SSID ssj0014589
Score 2.6072605
Snippet The polycomb repressive complex 2 (PRC2) consists of core subunits SUZ12, EED, RBBP4/7, and EZH1/2 and is responsible for mono-, di-, and tri-methylation of...
SourceID hal
proquest
crossref
pubmed
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 408
SubjectTerms AEBP2
C10ORF12
EZH2
H3K27me2
H3K27me3
LCOR
Life Sciences
PALI1
polycomb
PRC2
Title A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities
URI https://dx.doi.org/10.1016/j.molcel.2018.03.005
https://www.ncbi.nlm.nih.gov/pubmed/29628311
https://search.proquest.com/docview/2023412866
https://hal.science/hal-03951752
Volume 70
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBZ5UOil9N1N26CWXsXa1ss-ek3Ctt0mIW3C0ouQLJlsSe2QdQL77zvjx0IPodCLQUKy5dF49Mkz-oaQT7xKtfNBMgsAn4nAI-YymzHlXGxtpVXWkVV_O1HzC_FlKZc7pBjPwmBY5WD7e5veWeuhZjpIc3qzWk2_o-800UqCUkZxinZ4H7nMQbX389nl18XWmSBklwkP2zPsMJ6g68K8fjfXZUAfRJz2bKfyoRVq9wpDJR_Cod16dPyUPBmAJM37sT4jO6F-Th71qSU3L8gqp31OC9pU9DLctuggbgPr8s1Xq5KeNdcbeGm3pkc1nmv31G0ooEG6KE7Pp3hZUOSkXtMZRj-WgZ6dFwkFQ4N_bWledmknYJ_9klwcH_0o5mxIq8BKQGMt49apSltkpo9USL0TsVWR46ULXqSwXdOldrHjSngRWQF4SoggQyV0Iix3nr8ie3VThzeEBid8BZDFugxap8EKD7ZfWg-4JPFCTggbRWluevYMM4aV_TK96A2K3kTcgOgnRI_yNn9pgQED_4-eH2F6tg9B0ux5vjBYF3FAkVom9_GEfBhnz8BXhK4RW4fmbm0wibyApVqpCXndT-v2XkmmAIPF8cF_D-4teYylLk6SvyN77e1deA9YpnWHg64ekt3PyxmUTorl6c8_qZryGA
link.rule.ids 230,314,780,784,885,3506,27569,27924,27925,45663,45874
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwELYoqCqXqu9uW1q36tXaJH4lx7ACbUugiALiZtmxo24FCWID0v57ZvJYqQeE1EsOjp0448n4s2c8HyHfeZVq54NkFgA-E4FHzGU2Y8q52NpKq6xLVn14pOZn4ueFvNggs_EsDIZVDra_t-mdtR5KpoM0p9eLxfQ3-k4TrSQoZRSnaIe3AA0oUPatfPf8oFg7E4TsmPCwPsMG4wm6LszrqrksA_og4rTPdiofmqGe_MFQyYdwaDcf7b8gzwcgSfO-ry_JRqhfkac9teTqNVnktOe0oE1Fz8NNiw7iNrCOb75alPS4uVzBR7sl3avxXLunbkUBDdJi9utkipeCYk7qJd3F6Mcy0OOTWULB0OCuLc3LjnYC1tlvyNn-3ulszgZaBVYCGmsZt05V2mJm-kiF1DsRWxU5XrrgRQrLNV1qFzuuhBeRFYCnhAgyVEInwnLn-VuyWTd1eE9ocMJXAFmsy6B2GqzwYPul9YBLEi_khLBRlOa6z55hxrCyv6YXvUHRm4gbEP2E6FHe5h8tMGDgH2n5DYZn_RJMmj3PC4NlEQcUqWVyF0_I13H0DPxF6BqxdWhulwZJ5AVM1UpNyLt-WNfPSjIFGCyOP_x3576QZ_PTw8IUP44OPpJtvNPFTPJPZLO9uQ07gGta93nQ23vMKvJE
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+Family+of+Vertebrate-Specific+Polycombs+Encoded+by+the+LCOR%2FLCORL+Genes+Balance+PRC2+Subtype+Activities&rft.jtitle=Molecular+cell&rft.au=Conway%2C+Eric&rft.au=Jerman%2C+Emilia&rft.au=Healy%2C+Evan&rft.au=Ito%2C+Shinsuke&rft.date=2018-05-03&rft.eissn=1097-4164&rft.volume=70&rft.issue=3&rft.spage=408&rft.epage=421.e8&rft_id=info:doi/10.1016%2Fj.molcel.2018.03.005&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1097-2765&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1097-2765&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1097-2765&client=summon