Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer's Disease Pathogenesis

• Published in: The Journal of neuroscience Vol. 42; no. 8; pp. 1574 - 1586
• Main Authors: Islam, Sadequl, Sun, Yang, Gao, Yuan, Nakamura, Tomohisa, Noorani, Arshad Ali, Li, Tong, Wong, Philip C., Kimura, Noriyuki, Matsubara, Etsuro, Kasuga, Kensaku, Ikeuchi, Takeshi, Tomita, Taisuke, Zou, Kun, Michikawa, Makoto
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 23.02.2022
• Subjects: Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid beta-Peptides - genetics; Amyloid beta-Peptides - metabolism; Amyloid beta-Protein Precursor - genetics; Amyloid beta-Protein Precursor - metabolism; Amyloid Precursor Protein Secretases - genetics; Amyloid Precursor Protein Secretases - metabolism; Apolipoprotein E; Apolipoprotein E4; Apolipoprotein E4 - genetics; Apolipoprotein E4 - metabolism; Dementia disorders; Humans; Mutation; Neurodegenerative diseases; Nicastrin; Nuclear transport; Pathogenesis; Presenilin; Presenilin 1; Presenilin-1 - genetics; Presenilin-1 - metabolism; Presenilin-2 - genetics; Presenilin-2 - metabolism; Risk analysis; Risk factors; Secretase; Secretion; Senile plaques; Translocation; β-Amyloid; sporadic AD; apolipoprotein E; secretion; familial AD; presenilin

Alzheimer's disease (AD) is a debilitating dementia characterized by progressive memory loss and aggregation of amyloid-β (Aβ) protein into amyloid plaques in patient brains. Mutations in presenilin (PS) lead to abnormal generation of Aβ, which is the major cause of familial AD (FAD), and apoli...