The Retroviral Hypermutation Specificity of APOBEC3F and APOBEC3G Is Governed by the C-terminal DNA Cytosine Deaminase Domain

The human proteins APOBEC3F and APOBEC3G restrict retroviral infection by deaminating cytosine residues in the first cDNA strand of a replicating virus. These proteins have two putative deaminase domains, and it is unclear whether one or both catalyze deamination, unlike their homologs, AID and APOB...

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Bibliographic Details
Published inThe Journal of biological chemistry Vol. 280; no. 12; pp. 10920 - 10924
Main Authors Haché, Guylaine, Liddament, Mark T., Harris, Reuben S.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 25.03.2005
American Society for Biochemistry and Molecular Biology
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