Association between metabolic syndrome, insulin resistance, and IGF-1 in breast cancer survivors of DIANA-5 study

• Published in: Journal of cancer research and clinical oncology Vol. 149; no. 11; pp. 8639 - 8648
• Main Authors: De Santi, Mauro, Annibalini, Giosuè, Marano, Giuseppe, Biganzoli, Giacomo, Venturelli, Elisabetta, Pellegrini, Massimo, Lucertini, Francesco, Brandi, Giorgio, Biganzoli, Elia, Barbieri, Elena, Villarini, Anna
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2023; Springer Nature B.V
• Subjects: Aged; Blood glucose; Breast cancer; breast neoplasms; Breast Neoplasms - complications; Cancer Research; Cancer Survivors; Cholesterol; Cholesterol, HDL; Diagnosis; diet; Female; Hematology; High density lipoprotein; high density lipoprotein cholesterol; Humans; insulin; Insulin Resistance; Insulin-like growth factor I; Insulin-Like Growth Factor I - metabolism; Insulin-like growth factors; Internal Medicine; lifestyle; Medicine; Medicine & Public Health; Metabolic syndrome; Metabolic Syndrome - complications; nutritional intervention; obesity; Oncology; Physical activity; risk; Survivors; Tertiary cancer prevention; IGF-1; Breast cancer survivors; Metabolic syndrome

Purpose Circulating insulin-like growth factor-1 (IGF-1) is positively associated with the risk of BC recurrence, and is more frequently dysregulated in older people, especially in those with metabolic syndrome (MetS) and obesity. This study aimed to analyze the association between IGF-1 levels and...