Role of vanilloid VR1 receptor in thermal allodynia and hyperalgesia in diabetic mice

• Published in: European journal of pharmacology Vol. 422; no. 1; pp. 83 - 86
• Main Authors: Kamei, Junzo, Zushida, Ko, Morita, Kayo, Sasaki, Mitsumasa, Tanaka, Shun-ichi
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 22.06.2001; Elsevier
• Subjects: Allodynia; Animals; Associated diseases and complications; Biological and medical sciences; Capsaicin; Diabetes; Diabetes Mellitus, Experimental - physiopathology; Diabetes. Impaired glucose tolerance; Dose-Response Relationship, Drug; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Hyperalgesia; Hyperalgesia - physiopathology; Hyperalgesia - prevention & control; Immune Sera - pharmacology; Injections, Spinal; Male; Medical sciences; Mice; Mice, Inbred ICR; Pain - physiopathology; Pain - prevention & control; Pain Measurement - methods; Receptors, Drug - immunology; Receptors, Drug - physiology; Spinal cord; Vanilloid VR1 receptor; Allodynia; Spinal cord; Diabetes; Capsaicin; Vanilloid VR1 receptor; Hyperalgesia; Endocrinopathy; Pathogenesis; Diabetes mellitus; Rodentia; Central nervous system; Thermal stimulus; Vertebrata; Mammalia; Mouse; Animal; Complication; Sensory neuron; Brain (vertebrata); Biological receptor

We examined the role of the vanilloid VR1 receptor in the thermal hyperalgesia and allodynia seen in diabetic mice. Tail-flick latencies at source voltages of 35 and 50 V for a 50-W projection bulb in diabetic mice were significantly shorter than those in non-diabetic mice. Tail-flick latencies at 3...