Role of Traditional Chinese Medicine in Bone Regeneration and Osteoporosis
According to World Health Organization (WHO), osteoporosis is a systematic bone disability marked by reduced bone mass and microarchitectural degeneration of osseous cells, which leads to increased bones feebleness and fractures vulnerability. It is a polygenetic, physiological bone deformity that f...
Saved in:
Published in | Frontiers in bioengineering and biotechnology Vol. 10; p. 911326 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
31.05.2022
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | According to World Health Organization (WHO), osteoporosis is a systematic bone disability marked by reduced bone mass and microarchitectural degeneration of osseous cells, which leads to increased bones feebleness and fractures vulnerability. It is a polygenetic, physiological bone deformity that frequently leads to osteoporotic fractures and raises the risk of fractures in minimal trauma. Additionally, the molecular changes that cause osteoporosis are linked to decreased fracture repair and delayed bone regeneration. Bones have the ability to regenerate as part of the healing mechanism after an accident or trauma, including musculoskeletal growth and ongoing remodeling throughout adulthood. The principal treatment approaches for bone loss illnesses, such as osteoporosis, are hormone replacement therapy (HRT) and bisphosphonates. In this review, we searched literature regarding the Traditional Chinese medicines (TCM) in osteoporosis and bone regeneration. The literature results are summarized in this review for osteoporosis and bone regeneration. Traditional Chinese medicines (TCM) have grown in popularity as a result of its success in curing ailments while causing minimal adverse effects. Natural Chinese medicine has already been utilized to cure various types of orthopedic illnesses, notably osteoporosis, bone fractures and rheumatism with great success. TCM is a discipline of conventional remedy that encompasses herbal medication, massage (tui na), acupuncture, food, and exercise (qigong) therapy. It is based on more than 2,500 years of Chinese healthcare profession. This article serves as a comprehensive review summarizing the osteoporosis, bone regeneration and the traditional Chinese medicines used since ancient times for the management of osteoporosis and bone regeneration. |
---|---|
AbstractList | According to World Health Organization (WHO), osteoporosis is a systematic bone disability marked by reduced bone mass and microarchitectural degeneration of osseous cells, which leads to increased bones feebleness and fractures vulnerability. It is a polygenetic, physiological bone deformity that frequently leads to osteoporotic fractures and raises the risk of fractures in minimal trauma. Additionally, the molecular changes that cause osteoporosis are linked to decreased fracture repair and delayed bone regeneration. Bones have the ability to regenerate as part of the healing mechanism after an accident or trauma, including musculoskeletal growth and ongoing remodeling throughout adulthood. The principal treatment approaches for bone loss illnesses, such as osteoporosis, are hormone replacement therapy (HRT) and bisphosphonates. In this review, we searched literature regarding the Traditional Chinese medicines (TCM) in osteoporosis and bone regeneration. The literature results are summarized in this review for osteoporosis and bone regeneration. Traditional Chinese medicines (TCM) have grown in popularity as a result of its success in curing ailments while causing minimal adverse effects. Natural Chinese medicine has already been utilized to cure various types of orthopedic illnesses, notably osteoporosis, bone fractures and rheumatism with great success. TCM is a discipline of conventional remedy that encompasses herbal medication, massage (tui na), acupuncture, food, and exercise (qigong) therapy. It is based on more than 2,500 years of Chinese healthcare profession. This article serves as a comprehensive review summarizing the osteoporosis, bone regeneration and the traditional Chinese medicines used since ancient times for the management of osteoporosis and bone regeneration. According to World Health Organization (WHO), osteoporosis is a systematic bone disability marked by reduced bone mass and microarchitectural degeneration of osseous cells, which leads to increased bones feebleness and fractures vulnerability. It is a polygenetic, physiological bone deformity that frequently leads to osteoporotic fractures and raises the risk of fractures in minimal trauma. Additionally, the molecular changes that cause osteoporosis are linked to decreased fracture repair and delayed bone regeneration. Bones have the ability to regenerate as part of the healing mechanism after an accident or trauma, including musculoskeletal growth and ongoing remodeling throughout adulthood. The principal treatment approaches for bone loss illnesses, such as osteoporosis, are hormone replacement therapy (HRT) and bisphosphonates. In this review, we searched literature regarding the Traditional Chinese medicines (TCM) in osteoporosis and bone regeneration. The literature results are summarized in this review for osteoporosis and bone regeneration. Traditional Chinese medicines (TCM) have grown in popularity as a result of its success in curing ailments while causing minimal adverse effects. Natural Chinese medicine has already been utilized to cure various types of orthopedic illnesses, notably osteoporosis, bone fractures and rheumatism with great success. TCM is a discipline of conventional remedy that encompasses herbal medication, massage (tui na), acupuncture, food, and exercise (qigong) therapy. It is based on more than 2,500 years of Chinese healthcare profession. This article serves as a comprehensive review summarizing the osteoporosis, bone regeneration and the traditional Chinese medicines used since ancient times for the management of osteoporosis and bone regeneration.According to World Health Organization (WHO), osteoporosis is a systematic bone disability marked by reduced bone mass and microarchitectural degeneration of osseous cells, which leads to increased bones feebleness and fractures vulnerability. It is a polygenetic, physiological bone deformity that frequently leads to osteoporotic fractures and raises the risk of fractures in minimal trauma. Additionally, the molecular changes that cause osteoporosis are linked to decreased fracture repair and delayed bone regeneration. Bones have the ability to regenerate as part of the healing mechanism after an accident or trauma, including musculoskeletal growth and ongoing remodeling throughout adulthood. The principal treatment approaches for bone loss illnesses, such as osteoporosis, are hormone replacement therapy (HRT) and bisphosphonates. In this review, we searched literature regarding the Traditional Chinese medicines (TCM) in osteoporosis and bone regeneration. The literature results are summarized in this review for osteoporosis and bone regeneration. Traditional Chinese medicines (TCM) have grown in popularity as a result of its success in curing ailments while causing minimal adverse effects. Natural Chinese medicine has already been utilized to cure various types of orthopedic illnesses, notably osteoporosis, bone fractures and rheumatism with great success. TCM is a discipline of conventional remedy that encompasses herbal medication, massage (tui na), acupuncture, food, and exercise (qigong) therapy. It is based on more than 2,500 years of Chinese healthcare profession. This article serves as a comprehensive review summarizing the osteoporosis, bone regeneration and the traditional Chinese medicines used since ancient times for the management of osteoporosis and bone regeneration. |
Author | You, Qinjian Peng, Zhicai Xu, Ronghua |
AuthorAffiliation | Department of Orthopaedics, Yongchuan Hospita of Traditional Chinese Medicine, Chongqing Medical Uninersity , Chongqing , China |
AuthorAffiliation_xml | – name: Department of Orthopaedics, Yongchuan Hospita of Traditional Chinese Medicine, Chongqing Medical Uninersity , Chongqing , China |
Author_xml | – sequence: 1 givenname: Zhicai surname: Peng fullname: Peng, Zhicai – sequence: 2 givenname: Ronghua surname: Xu fullname: Xu, Ronghua – sequence: 3 givenname: Qinjian surname: You fullname: You, Qinjian |
BookMark | eNp1kUtvUzEQhS1UREvpD2DnJZsEv6-9QYKIR1FRpSp7y49x6urGDvZNJf49N0mRKBKrGY3P-caa8xqdlVoAobeULDnX5n3yucKSEcaWhlLO1At0wZhRC0G1PPurP0dXvT8QQiiTg9TsFTrncqBUcXmBvt_VEXBNeN1czFOuxY14dZ8LdMA_IOYwtzgX_Gneju9gAwWaO-iwKxHf9gnqrrbac3-DXiY3drh6qpdo_eXzevVtcXP79Xr18WYRJNHTgouBSy1lIiy6EAfCqdKJckpJkIZRoryWXkeveHDJBwhmIEIJJ00ywPkluj5hY3UPdtfy1rVftrpsj4PaNta1KYcRLGEDTUIKIMwLH7VxNCkZJZFeUSr8zPpwYu32fgsxQJmaG59Bn7-UfG839dEaagQxega8ewK0-nMPfbLb3AOMoytQ990yNWjB-CAO0uEkDfO1eoNkQ56Ol5zJebSU2EOu9pirPeRqT7nOTvqP888H_-_5DSaapuo |
CitedBy_id | crossref_primary_10_1016_j_phymed_2023_155137 crossref_primary_10_1186_s13020_024_00883_4 crossref_primary_10_1371_journal_pone_0289455 crossref_primary_10_1016_j_phymed_2023_154745 crossref_primary_10_3390_ijms24054876 crossref_primary_10_3389_fphar_2023_1203767 crossref_primary_10_1016_j_jep_2024_118141 crossref_primary_10_12677_ces_2024_1212886 crossref_primary_10_1016_j_prmcm_2024_100390 crossref_primary_10_2147_DMSO_S446318 crossref_primary_10_1016_j_ajps_2024_100988 crossref_primary_10_1097_MD_0000000000036489 crossref_primary_10_1186_s13018_025_05504_w crossref_primary_10_15188_kjopp_2024_08_38_4_101 crossref_primary_10_3389_fphar_2025_1516038 crossref_primary_10_3892_br_2023_1715 crossref_primary_10_1002_fsn3_4604 crossref_primary_10_1007_s11596_023_2782_x crossref_primary_10_1016_j_jchromb_2023_123762 crossref_primary_10_1093_rb_rbae070 crossref_primary_10_54817_IC_v65n3a11 crossref_primary_10_3389_fendo_2023_1276631 crossref_primary_10_1049_nbt2_12136 crossref_primary_10_3389_fendo_2023_1158042 crossref_primary_10_1111_eci_14198 crossref_primary_10_1186_s13036_023_00354_8 crossref_primary_10_1016_j_jep_2023_117480 crossref_primary_10_3389_fendo_2022_1015483 crossref_primary_10_1002_adbi_202400166 crossref_primary_10_1016_j_jep_2024_118234 crossref_primary_10_1016_j_jep_2024_118690 crossref_primary_10_5582_ddt_2024_01006 crossref_primary_10_3390_ijms242417389 crossref_primary_10_1097_MD_0000000000035061 crossref_primary_10_3389_fendo_2023_1234683 crossref_primary_10_3389_fphar_2024_1456796 crossref_primary_10_1016_j_indcrop_2023_117749 crossref_primary_10_3389_fphar_2024_1370900 crossref_primary_10_1097_MD_0000000000034773 crossref_primary_10_1371_journal_pone_0289912 crossref_primary_10_3389_fphar_2023_1242194 crossref_primary_10_1016_j_jep_2022_115835 crossref_primary_10_1088_1748_605X_ad2554 crossref_primary_10_1142_S0192415X24500393 crossref_primary_10_1155_term_2812191 crossref_primary_10_18632_aging_206067 crossref_primary_10_1016_j_chmed_2023_09_006 crossref_primary_10_1016_j_heliyon_2024_e37249 |
Cites_doi | 10.1038/s41598-020-72797-8 10.1080/13697137.2016.1183624 10.1007/bf02980202 10.1016/j.intimp.2011.04.004 10.1016/j.jep.2006.04.020 10.2174/1389450118666170321105425 10.1016/j.bone.2005.11.019 10.1016/j.jep.2005.09.041 10.3389/fphar.2017.00266 10.1016/j.ejphar.2009.01.035 10.1017/s0007114513002043 10.1016/j.biocel.2014.03.005 10.1055/s-0043-100100 10.1016/j.bbrc.2011.02.017 10.1142/s0192415x02000351 10.3109/13880209.2014.884606 10.1111/j.1476-5381.2009.00593.x 10.1016/j.cellimm.2011.05.011 10.1016/j.phymed.2013.01.001 10.1016/j.phymed.2013.03.001 10.1038/srep32260 10.1186/1749-8546-2-13 10.1016/j.bone.2008.08.127 10.1016/j.bone.2007.12.136 10.1007/s11684-014-0362-y 10.1016/j.jep.2018.01.007 10.1016/j.cub.2017.05.064 10.1097/gme.0b013e318215101a 10.1016/j.maturitas.2008.03.010 10.1016/j.msec.2020.111760 10.2174/1568026616666160530181328 10.1142/s0192415x07005156 10.12659/msm.915170 10.1159/000447841 10.1016/j.fct.2018.03.013 10.3389/fphar.2018.00981 10.1172/jci.insight.125679 10.1002/art.40137 10.1002/jbmr.4171 10.1016/j.phyplu.2021.100049 10.1155/2020/5687421 10.1038/484455c 10.1515/folmed-2015-0037 10.1002/ptr.1683 10.3390/life11080783 10.1055/s-2001-18343 10.1097/gme.0b013e318265e7dd 10.1016/j.jep.2004.09.038 10.1016/s0925-4773(99)00142-2 10.1016/j.ejphar.2011.06.059 10.1359/jbmr.061113 10.1080/21655979.2021.2011637 10.1155/2013/356260 10.1002/14651858.CD005467.pub2 10.1056/nejmoa041943 10.1177/0885328215581551 10.1016/j.jep.2009.02.034 10.1016/s0020-1383(09)00642-1 10.1371/journal.pone.0087864 10.1016/j.joms.2006.01.017 10.5152/eurjrheum.2016.048 10.3892/mmr.2019.10209 10.1359/jbmr.070405 10.7554/eLife.66275 10.3390/molecules14062049 10.1016/j.ejphar.2007.10.013 10.1016/j.intimp.2008.01.027 10.1016/j.abb.2014.06.003 10.1038/nbt1007-1110 10.1007/s00268-007-9394-7 10.1002/ptr.2560 10.3892/ijmm.2012.1079 10.1016/j.intimp.2011.05.011 10.1201/9781315117294-14 10.1097/gme.0000000000000673 10.1016/j.maturitas.2008.09.023 10.1016/j.jep.2014.09.033 10.1016/j.bone.2015.01.002 10.1359/jbmr.2002.17.3.513 10.1142/s0192415x96000104 10.1016/j.fitote.2014.07.013 10.1016/j.semcdb.2008.08.002 10.1097/gme.0b013e31814fad27 10.1016/j.intimp.2011.01.018 10.7150/ijms.6084 10.1016/j.phymed.2009.01.005 10.1016/j.archoralbio.2011.06.008 10.1001/jama.2016.11136 10.1016/j.phymed.2011.03.002 10.1016/j.fct.2013.09.019 10.1007/978-1-62703-373-2_32 10.1186/s12906-018-2171-3 10.1007/s11657-016-0301-4 10.1016/j.bone.2014.06.010 10.1007/BF03026324 10.1038/sj.ebd.6401243 10.1155/2017/6062707 10.1210/js.2018-00118 10.1007/978-3-662-09163-0_3 10.1016/j.ejphar.2011.04.047 10.1016/j.carbpol.2017.06.051 10.1097/gme.0000000000000201 10.1097/01.blo.0000163836.66906.74 10.2106/00004623-199708000-00019 10.15386/cjmed-838 10.4103/0971-6580.155323 10.1186/1741-7015-9-66 10.1016/j.bone.2008.10.035 10.1016/S1875-5364(14)60034-0 10.1155/2021/5338182 10.3892/etm.2015.2616 10.1055/s-2006-957839 10.1111/j.1422-2213.2007.00311.x 10.1089/scd.2013.0261 10.1017/s0007114507801589 10.1002/jbmr.3031 10.3390/ijms20010083 10.1097/00003086-199810001-00003 10.1016/j.injury.2005.07.029 10.1016/j.jsbmb.2014.08.002 10.1007/s00198-011-1577-2 |
ContentType | Journal Article |
Copyright | Copyright © 2022 Peng, Xu and You. Copyright © 2022 Peng, Xu and You. 2022 Peng, Xu and You |
Copyright_xml | – notice: Copyright © 2022 Peng, Xu and You. – notice: Copyright © 2022 Peng, Xu and You. 2022 Peng, Xu and You |
DBID | AAYXX CITATION 7X8 5PM DOA |
DOI | 10.3389/fbioe.2022.911326 |
DatabaseName | CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
DatabaseTitle | CrossRef MEDLINE - Academic |
DatabaseTitleList | CrossRef MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journal Collection url: https://www.doaj.org/ sourceTypes: Open Website |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Engineering |
DocumentTitleAlternate | Peng et al |
EISSN | 2296-4185 |
ExternalDocumentID | oai_doaj_org_article_0271f454e02b4bd89a1f65d505b6114b PMC9194098 10_3389_fbioe_2022_911326 |
GroupedDBID | 53G 5VS 9T4 AAFWJ AAYXX ACGFS ACXDI ADBBV ADRAZ AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK GROUPED_DOAJ GX1 HYE KQ8 M48 M~E OK1 PGMZT RPM 7X8 5PM |
ID | FETCH-LOGICAL-c508t-34735855f02dacd703168f13110c592106b85b8db63cafbcec970464a59f9e33 |
IEDL.DBID | M48 |
ISSN | 2296-4185 |
IngestDate | Wed Aug 27 01:31:42 EDT 2025 Thu Aug 21 18:07:44 EDT 2025 Fri Jul 11 06:46:45 EDT 2025 Thu Apr 24 23:08:19 EDT 2025 Tue Jul 01 02:45:52 EDT 2025 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Language | English |
License | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c508t-34735855f02dacd703168f13110c592106b85b8db63cafbcec970464a59f9e33 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Reviewed by: Anjali P. Kusumbe, University of Oxford, United Kingdom Edited by: Antonella Motta, University of Trento, Italy Francesco Grassi, Rizzoli Orthopedic Institute (IRCCS), Italy This article was submitted to Tissue Engineering and Regenerative Medicine, a section of the journal Frontiers in Bioengineering and Biotechnology |
OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.3389/fbioe.2022.911326 |
PMID | 35711635 |
PQID | 2678423748 |
PQPubID | 23479 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_0271f454e02b4bd89a1f65d505b6114b pubmedcentral_primary_oai_pubmedcentral_nih_gov_9194098 proquest_miscellaneous_2678423748 crossref_citationtrail_10_3389_fbioe_2022_911326 crossref_primary_10_3389_fbioe_2022_911326 |
ProviderPackageCode | CITATION AAYXX |
PublicationCentury | 2000 |
PublicationDate | 2022-05-31 |
PublicationDateYYYYMMDD | 2022-05-31 |
PublicationDate_xml | – month: 05 year: 2022 text: 2022-05-31 day: 31 |
PublicationDecade | 2020 |
PublicationTitle | Frontiers in bioengineering and biotechnology |
PublicationYear | 2022 |
Publisher | Frontiers Media S.A |
Publisher_xml | – name: Frontiers Media S.A |
References | Zhu (B138) 1998 Zhang (B135) 2013; 20 Cho (B13) 2002; 17 Ferguson (B20) 1999; 87 Hejazi (B31) 2018; 115 Hopkins (B32) 2007; 25 Xu (B116) 2014; 51 Xie (B115) 2015; 30 Liu (B70) 2014; 157 Giannoudis (B25) 2009; 40 He (B30) 2017; 12 Yang (B119) 2016; 39 Ma (B74) 1996; 24 Wong (B113) 2006; 64 Burge (B8) 2007; 22 Sheng (B89) 2013; 10 Yu (B124) 1999; 2 Zhang (B132) 2020; 10 Ivanova (B37) 2015; 57 Li (B56) 2009; 14 Miller (B76) 2016; 316 Wazzani (B109) 2021; 11 Li (B53) 2013; 20 Liu (B67) 2014; 23 Srivastava (B96) 2013; 20 Lee (B50) 2008; 8 Wang (B105) 2017; 8 Choi (B14) 2011; 11 Sheng (B90) 2012; 484 Audigé (B3) 2005; 438 Zhang (B127) 2009; 44 Shi (B91) 2017; 2017 Zhang (B130) 2009; 45 Mok (B78) 2010; 159 Lee (B47) 2011; 668 Liu (B69) 2014; 1 Zhang (B126) 2006; 38 Nian (B80) 2006; 108 Russow (B85) 2019; 20 Huh (B36) 2006; 104 Tang (B102) 2018; 18 Wang (B107) 2017; 174 Wong (B111) 2013 Giannoudis (B24) 2005; 36 Reid (B84) 2008 Lee (B52) 2011; 11 Society (B93) 2021 Wei (B110) 2007; 35 Haung (B29) 2003; 12 Schnatz (B86) 2011; 18 Yoon (B123) 2011; 664 Ju (B43) 2014; 8 Li (B59) 2021; 1 Ramchandani (B83) 2014; 21 Bates (B5) 2018; 1 Jiang (B40) 2005; 16 Yuan (B125) 2018; 220 Dinger (B18) 2016; 19 Sözen (B94) 2017; 4 Tan (B99) 2017; 32 Mukwaya (B79) 2014; 52 Dai (B16) 2009; 607 Huang (B34) 2014; 66 Lin (B65) 2002; 30 Liu (B72) 2018 Cosman (B21) 2014 Bone (B6) 2007; 22 Lee (B48) 2009; 23 Matuk (B75) 2006; 32 Gan (B22) 2019; 25 Li (B58) 2014; 12 Guerrini (B26) 2014; 561 Kim (B46) 2014; 98 Zhang (B133) 2008; 15 Anderson (B1) 2002; 17 Lee (B49) 2011; 11 Ye (B121) 2014; 9 Bartl (B4) 2004 Jiang (B41) 2002; 27 Liang (B61) 2020; 2020 Jeong (B38) 2005; 96 Shahinian (B88) 2005; 352 Aronson (B2) 1997; 79 Hsiao (B33) 2007; 10 Li (B55) 2011; 18 Chen (B11) 2020; 35 Cao (B9) 2008; 59 Ha (B27) 2003; 26 Limmer (B64) 2017; 155 Buckley (B7) 2017; 69 Liu (B68) 2005; 30 Wang (B106) 2017; 18 Tang (B101) 2021; 120 Spivakovsky (B95) 2017; 18 Yang (B120) 2021; 2021 Singh (B92) 2019; 4 Wang (B104) 2001; 67 Zhang (B129) 2008; 61 Zhu (B137) 2012; 23 Dimitriou (B17) 2011; 9 Zhang (B131) 2021; 10 Liu (B71) 2016; 6 Cui (B15) 2019; 19 Kawamata (B44) 2008; 32 Jiao (B42) 2009; 16 Zhu (B136) 2015; 8 Gao (B23) 1985; 5 Huang (B35) 2015; 74 Liang (B62) 2012; 30 Wong (B112) 2007; 2 Li (B60) 2015; 10 Lungu (B73) 2018; 91 Xu (B118) 1991 Kihara (B45) 2011; 406 Ye (B122) 2016; 16 Jeremiah (B39) 2015; 92 Sze (B98) 2009; 123 Suvarna (B97) 2018; 9 Miura (B77) 1996; 62 Tang (B100) 2008; 579 Xiao (B114) 2014; 144 Xu (B117) 2016; 23 Haas (B28) 2018; 2 Vickers (B103) 2017; 27 Qin (B82) 2005 Wang (B108) 2013; 2013 Chen (B10) 2013; 62 Zhang (B134) 2008; 99 (B81) 2004 Seo (B87) 2005; 19 Li (B57) 2022; 13 Zhang (B128) 2007; 22 Einhorn (B19) 1998 Lee (B51) 2011; 270 Liu (B66) 1991; 16 Li (B54) 2014; 21 Liao (B63) 2014; 111 Chen (B12) 2011; 56 |
References_xml | – start-page: 973 volume-title: Management of Osteoporosis in Postmenopausal Women: The 2021 Position Statement of the North American Menopause Society year: 2021 ident: B93 – volume: 10 start-page: 15730 year: 2020 ident: B132 article-title: Network Pharmacology Based Virtual Screening of Active Constituents of Prunella Vulgaris L. And the Molecular Mechanism against Breast Cancer publication-title: Sci. Rep. doi: 10.1038/s41598-020-72797-8 – volume: 19 start-page: 349 year: 2016 ident: B18 article-title: Drospirenone Plus Estradiol and the Risk of Serious Cardiovascular Events in Postmenopausal Women publication-title: Climacteric doi: 10.1080/13697137.2016.1183624 – volume: 26 start-page: 929 year: 2003 ident: B27 article-title: Effects of Eucommiae Cortex on Osteoblast-like Cell Proliferation and Osteoclast Inhibition publication-title: Arch. Pharm. Res. doi: 10.1007/bf02980202 – volume: 11 start-page: 1251 year: 2011 ident: B49 article-title: Protective Effect of Kobophenol A on Nitric Oxide-Induced Cell Apoptosis in Human Osteoblast-like MG-63 Cells: Involvement of JNK, NF-Κb and AP-1 Pathways publication-title: Int. Immunopharmacol. doi: 10.1016/j.intimp.2011.04.004 – volume: 108 start-page: 96 year: 2006 ident: B80 article-title: Antiosteoporotic Activity of Er-Xian Decoction, a Traditional Chinese Herbal Formula, in Ovariectomized Rats publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2006.04.020 – volume: 18 start-page: 1051 year: 2017 ident: B106 article-title: Therapeutic Potential and Outlook of Alternative Medicine for Osteoporosis publication-title: Curr. Drug Targets doi: 10.2174/1389450118666170321105425 – volume: 38 start-page: 818 year: 2006 ident: B126 article-title: Flavonoids Derived from Herbal Epimedium Brevicornum Maxim Prevent OVX-Induced Osteoporosis in Rats Independent of its Enhancement in Intestinal Calcium Absorption publication-title: Bone doi: 10.1016/j.bone.2005.11.019 – volume: 104 start-page: 345 year: 2006 ident: B36 article-title: Puerariae Radix Promotes Differentiation and Mineralization in Human Osteoblast-like SaOS-2 Cells publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2005.09.041 – volume: 8 start-page: 266 year: 2017 ident: B105 article-title: Antioxidant Effect of Fructus Ligustri Lucidi Aqueous Extract in Ovariectomized Rats Is Mediated through Nox4-ROS-NF-Κb Pathway publication-title: Front. Pharmacol. doi: 10.3389/fphar.2017.00266 – volume: 607 start-page: 1 year: 2009 ident: B16 article-title: Effects of Naringin on the Proliferation and Osteogenic Differentiation of Human Bone Mesenchymal Stem Cell publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2009.01.035 – volume: 111 start-page: 55 year: 2014 ident: B63 article-title: Genistein Induces Oestrogen Receptor-α Gene Expression in Osteoblasts through the Activation of Mitogen-Activated Protein kinases/NF-κB/activator Protein-1 and Promotes Cell Mineralisation publication-title: Br. J. Nutr. doi: 10.1017/s0007114513002043 – volume: 51 start-page: 1 year: 2014 ident: B116 article-title: Salvianolic Acid B Promotes Osteogenesis of Human Mesenchymal Stem Cells through Activating ERK Signaling Pathway publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/j.biocel.2014.03.005 – volume-title: Osteogenesis and Bone Regeneration year: 2018 ident: B72 article-title: Traditional Chinese Medicine Therapy for Targeting Osteoblastogenesis – volume: 32 start-page: 1 year: 2006 ident: B75 article-title: Seeing the Body: The Divergence of Ancient Chinese and Western Medical Illustration publication-title: J. Biocommunication – volume: 155 start-page: 273 year: 2017 ident: B64 article-title: Osteoimmunology: Influence of the Immune System on Bone Regeneration and Consumption publication-title: Z Orthop. Unf. doi: 10.1055/s-0043-100100 – volume: 406 start-page: 211 year: 2011 ident: B45 article-title: Acerogenin A, a Natural Compound Isolated from Acer Nikoense Maxim, Stimulates Osteoblast Differentiation through Bone Morphogenetic Protein Action publication-title: Biochem. Biophysical Res. Commun. doi: 10.1016/j.bbrc.2011.02.017 – volume: 30 start-page: 271 year: 2002 ident: B65 article-title: The Effect of Chinese Medicine on Bone Cell Activities publication-title: Am. J. Chin. Med. doi: 10.1142/s0192415x02000351 – volume-title: International Statistical Classification of Diseases and Related Health Problems: Alphabetical Index year: 2004 ident: B81 – volume: 52 start-page: 1223 year: 2014 ident: B79 article-title: Chinese Herbal Medicine for Bone Health publication-title: Pharm. Biol. doi: 10.3109/13880209.2014.884606 – volume: 159 start-page: 939 year: 2010 ident: B78 article-title: Icariin Protects against Bone Loss Induced by Oestrogen Deficiency and Activates Oestrogen Receptor-dependent Osteoblastic Functions in UMR 106 Cells publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2009.00593.x – volume: 2 start-page: 7 year: 1999 ident: B124 article-title: In Vitro and In Vivo Studies of the Effect of a Chinese Herb Medicine on Osteoclastic Bone Resorption publication-title: Chin. J. Dent. Res. – volume: 270 start-page: 224 year: 2011 ident: B51 article-title: Apocynin Stimulates Osteoblast Differentiation and Inhibits Bone-Resorbing Mediators in MC3T3-E1 Cells publication-title: Cell. Immunol. doi: 10.1016/j.cellimm.2011.05.011 – volume: 20 start-page: 549 year: 2013 ident: B53 article-title: Antiosteoporotic Activity of Echinacoside in Ovariectomized Rats publication-title: Phytomedicine doi: 10.1016/j.phymed.2013.01.001 – volume: 20 start-page: 683 year: 2013 ident: B96 article-title: Assessment of the Role of Flavonoids for Inducing Osteoblast Differentiation in Isolated Mouse Bone Marrow Derived Mesenchymal Stem Cells publication-title: Phytomedicine doi: 10.1016/j.phymed.2013.03.001 – volume: 6 start-page: 32260 year: 2016 ident: B71 article-title: Wedelolactone Enhances Osteoblastogenesis by Regulating Wnt/β-Catenin Signaling Pathway but Suppresses Osteoclastogenesis by NF-κB/c-fos/NFATc1 Pathway publication-title: Sci. Rep. doi: 10.1038/srep32260 – volume: 2 start-page: 13 year: 2007 ident: B112 article-title: The Effects of Rhizoma Curculiginis and Rhizoma Drynariae Extracts on Bones publication-title: Chin. Med. doi: 10.1186/1749-8546-2-13 – volume: 45 start-page: 553 year: 2009 ident: B130 article-title: Du-Zhong (Eucommia Ulmoides Oliv.) Cortex Extract Prevent OVX-Induced Osteoporosis in Rats publication-title: Bone doi: 10.1016/j.bone.2008.08.127 – volume: 22 start-page: S37 year: 2007 ident: B6 article-title: A Randomized Double-Blind, Placebo-Controlled Study of a Cathepsin K Inhibitor in the Treatment of Postmenopausal Women with Low BMD: One Year Results publication-title: J. Bone Min. Res. doi: 10.1016/j.bone.2007.12.136 – volume: 8 start-page: 389 year: 2014 ident: B43 article-title: Mechanisms Of “Kidney Governing Bones” Theory in Traditional Chinese Medicine publication-title: Front. Med. doi: 10.1007/s11684-014-0362-y – volume: 220 start-page: 228 year: 2018 ident: B125 article-title: Bu-Shen-Tong-Luo Decoction Prevents Bone Loss via Inhibition of Bone Resorption and Enhancement of Angiogenesis in Ovariectomy-Induced Osteoporosis of Rats publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2018.01.007 – volume: 30 start-page: 1023 year: 2005 ident: B68 article-title: Effects on Secretory Function of Rat Gonad by Erxian Decoction and its Disassembled Prescriptions publication-title: Zhongguo Zhong Yao Za Zhi – volume: 27 start-page: R713 year: 2017 ident: B103 article-title: Animal Communication: When I'm Calling You, Will You Answer Too? publication-title: Curr. Biol. doi: 10.1016/j.cub.2017.05.064 – volume: 18 start-page: 1072 year: 2011 ident: B86 article-title: Osteoporosis Screening and Treatment Guidelines publication-title: Menopause doi: 10.1097/gme.0b013e318215101a – volume: 59 start-page: 373 year: 2008 ident: B9 article-title: Curculigo Orchioides, a Traditional Chinese Medicinal Plant, Prevents Bone Loss in Ovariectomized Rats publication-title: Maturitas doi: 10.1016/j.maturitas.2008.03.010 – volume: 16 start-page: 1014 year: 2005 ident: B40 article-title: Authentication Of “Bone Penetrating Herbs” publication-title: Lishizhen Med. Materia Medica Res. – volume: 120 start-page: 111760 year: 2021 ident: B101 article-title: Traditional Chinese Medicine and Orthopedic Biomaterials: Host of Opportunities from Herbal Extracts publication-title: Mater. Sci. Eng. C doi: 10.1016/j.msec.2020.111760 – volume: 16 start-page: 3646 year: 2016 ident: B122 article-title: Drug Repositioning through Network Pharmacology publication-title: Ctmc doi: 10.2174/1568026616666160530181328 – volume: 35 start-page: 663 year: 2007 ident: B110 article-title: Anti-osteoporosis Activity of Naringin in the Retinoic Acid-Induced Osteoporosis Model publication-title: Am. J. Chin. Med. doi: 10.1142/s0192415x07005156 – volume: 25 start-page: 5700 year: 2019 ident: B22 article-title: Network Pharmacology-Based Pharmacological Mechanism of the Chinese Medicine Rhizoma Drynariae against Osteoporosis publication-title: Med. Sci. Monit. doi: 10.12659/msm.915170 – volume: 39 start-page: 1369 year: 2016 ident: B119 article-title: Astragalus Polysaccharide Attenuated Iron Overload-Induced Dysfunction of Mesenchymal Stem Cells via Suppressing Mitochondrial ROS publication-title: Cell Physiol. Biochem. doi: 10.1159/000447841 – volume: 115 start-page: 244 year: 2018 ident: B31 article-title: Antioxidative and Anti-proliferative Potential of Curculigo Orchioides Gaertn in Oxidative Stress Induced Cytotoxicity: In Vitro, Ex Vivo and In Silico Studies publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2018.03.013 – volume: 9 start-page: 981 year: 2018 ident: B97 article-title: Bone Health and Natural Products- an Insight publication-title: Front. Pharmacol. doi: 10.3389/fphar.2018.00981 – volume: 4 year: 2019 ident: B92 article-title: Angiocrine Signals Regulate Quiescence and Therapy Resistance in Bone Metastasis publication-title: JCI Insight doi: 10.1172/jci.insight.125679 – volume: 69 start-page: 1521 year: 2017 ident: B7 article-title: 2017 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis publication-title: Arthritis & Rheumatology doi: 10.1002/art.40137 – volume: 35 start-page: 2103 year: 2020 ident: B11 article-title: Bone Vasculature and Bone Marrow Vascular Niches in Health and Disease publication-title: J. Bone Min. Res. doi: 10.1002/jbmr.4171 – volume: 1 start-page: 100049 year: 2021 ident: B59 article-title: Network Pharmacology Combined with Bioinformatics to Investigate the Mechanism of Xianlinggubao Capsule in the Treatment of Osteoporosis publication-title: Phytomedicine Plus doi: 10.1016/j.phyplu.2021.100049 – volume: 2020 start-page: 5687421 year: 2020 ident: B61 article-title: The Efficacy and Safety of Traditional Chinese Medicine Tonifying-Shen (Kidney) Principle for Primary Osteoporosis: a Systematic Review and Meta-Analysis of Randomized Controlled Trials publication-title: Evidence-Based Complementary Altern. Med. doi: 10.1155/2020/5687421 – volume: 484 start-page: 455 year: 2012 ident: B90 article-title: China's Bear Farms Prompt Public Outcry publication-title: Nature doi: 10.1038/484455c – volume: 57 start-page: 181 year: 2015 ident: B37 article-title: Osteoporosis: Therapeutic Options publication-title: Folia Med. Plovdiv. doi: 10.1515/folmed-2015-0037 – volume: 19 start-page: 231 year: 2005 ident: B87 article-title: Effect of Mornidae Radix Extracts on Experimental Osteoporosis in Sciatic Neurectomized Mice publication-title: Phytother. Res. doi: 10.1002/ptr.1683 – volume: 11 start-page: 783 year: 2021 ident: B109 article-title: Physical Activity and Bone Vascularization: a Way to Explore in Bone Repair Context? publication-title: Life doi: 10.3390/life11080783 – volume: 67 start-page: 748 year: 2001 ident: B104 article-title: Osteoblastic Proliferation Stimulating Activity ofPsoralea corylifoliaExtracts and Two of its Flavonoids publication-title: Planta Med. doi: 10.1055/s-2001-18343 – volume: 20 start-page: 232 year: 2013 ident: B135 article-title: Therapeutic Effect of Aqueous Extract from Ecliptae Herba on Bone Metabolism of Ovariectomized Rats publication-title: Menopause doi: 10.1097/gme.0b013e318265e7dd – volume: 96 start-page: 489 year: 2005 ident: B38 article-title: Stimulative Effects of Drynariae Rhizoma Extracts on the Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2004.09.038 – volume: 87 start-page: 57 year: 1999 ident: B20 article-title: Does Adult Fracture Repair Recapitulate Embryonic Skeletal Formation? publication-title: Mech. Dev. doi: 10.1016/s0925-4773(99)00142-2 – volume: 668 start-page: 383 year: 2011 ident: B47 article-title: Ugonin K Promotes Osteoblastic Differentiation and Mineralization by Activation of P38 MAPK- and ERK-Mediated Expression of Runx2 and Osterix publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2011.06.059 – volume: 22 start-page: 465 year: 2007 ident: B8 article-title: Incidence and Economic Burden of Osteoporosis-Related Fractures in the United States, 2005-2025 publication-title: J. Bone Min. Res. doi: 10.1359/jbmr.061113 – volume: 13 start-page: 164 year: 2022 ident: B57 article-title: Icariin Activates Autophagy to Trigger TGFβ1 Upregulation and Promote Angiogenesis in EA.Hy926 Human Vascular Endothelial Cells publication-title: Bioengineered doi: 10.1080/21655979.2021.2011637 – volume: 2013 start-page: 356260 year: 2013 ident: B108 article-title: Chinese Herbal Medicine for Osteoporosis: a Systematic Review of Randomized Controlled Trails publication-title: Evidence-Based Complementary Altern. Med. doi: 10.1155/2013/356260 – volume: 1 start-page: CD005467 year: 2014 ident: B69 article-title: Chinese Herbal Medicines for Treating Osteoporosis publication-title: Cochrane Database Syst. Rev. doi: 10.1002/14651858.CD005467.pub2 – volume: 352 start-page: 154 year: 2005 ident: B88 article-title: Risk of Fracture after Androgen Deprivation for Prostate Cancer publication-title: N. Engl. J. Med. doi: 10.1056/nejmoa041943 – volume: 30 start-page: 290 year: 2015 ident: B115 article-title: Icariin: A Promising Osteoinductive Compound for Repairing Bone Defect and Osteonecrosis publication-title: J. Biomater. Appl. doi: 10.1177/0885328215581551 – volume: 123 start-page: 27 year: 2009 ident: B98 article-title: A Novel Mechanism: Erxian Decoction, a Chinese Medicine Formula, for Relieving Menopausal Syndrome publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2009.02.034 – volume: 40 start-page: S1 year: 2009 ident: B25 article-title: Bone Morphogenetic Proteins in Musculoskeletal Medicine publication-title: Injury doi: 10.1016/s0020-1383(09)00642-1 – volume: 9 start-page: e87864 year: 2014 ident: B121 article-title: Construction of Drug Network Based on Side Effects and its Application for Drug Repositioning publication-title: PloS one doi: 10.1371/journal.pone.0087864 – volume: 64 start-page: 828 year: 2006 ident: B113 article-title: Traditional Chinese Medicines and Bone Formation-A Review publication-title: J. Oral Maxillofac. Surg. doi: 10.1016/j.joms.2006.01.017 – volume: 17 start-page: S454 year: 2002 ident: B1 article-title: The Effect of Gu-Sui-Bu (Drynaria Fortunei) on Bone Cell Activity: A Preliminary Study publication-title: J. bone mineral Res. – volume: 4 start-page: 46 year: 2017 ident: B94 article-title: An Overview and Management of Osteoporosis publication-title: Eur. J. Rheumatology doi: 10.5152/eurjrheum.2016.048 – volume: 16 start-page: 620 year: 1991 ident: B66 article-title: Effects of Epimedium Sagittatum Maxim. Polysaccharides on DNA Synthesis of Bone Marrow Cells of "yang Deficiency" Animal Model Caused by Hydroxyurea publication-title: Zhongguo Zhong Yao Za Zhi – volume: 19 start-page: 5053 year: 2019 ident: B15 article-title: Perspectives of Small Molecule Inhibitors of Activin Receptor-like K-inase in A-nti-tumor T-reatment and S-tem C-ell D-ifferentiation (Review) publication-title: Mol. Med. Rep. doi: 10.3892/mmr.2019.10209 – volume: 22 start-page: 1072 year: 2007 ident: B128 article-title: Epimedium-Derived Phytoestrogen Flavonoids Exert Beneficial Effect on Preventing Bone Loss in Late Postmenopausal Women: A 24-Month Randomized, Double-Blind and Placebo-Controlled Trial publication-title: J. Bone Min. Res. doi: 10.1359/jbmr.070405 – volume: 10 start-page: e66275 year: 2021 ident: B131 article-title: A Bone-specific Adipogenesis Pathway in Fat-free Mice Defines Key Origins and Adaptations of Bone Marrow Adipocytes with Age and Disease publication-title: Elife doi: 10.7554/eLife.66275 – volume: 14 start-page: 2049 year: 2009 ident: B56 article-title: Inhibitory Effects of Morinda Officinalis Extract on Bone Loss in Ovariectomized Rats publication-title: Molecules doi: 10.3390/molecules14062049 – volume: 579 start-page: 40 year: 2008 ident: B100 article-title: Enhancement of Bone Morphogenetic Protein-2 Expression and Bone Formation by Coumarin Derivatives via P38 and ERK-dependent Pathway in Osteoblasts publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2007.10.013 – volume: 8 start-page: 741 year: 2008 ident: B50 article-title: Emodin Accelerates Osteoblast Differentiation through Phosphatidylinositol 3-kinase Activation and Bone Morphogenetic Protein-2 Gene Expression publication-title: Int. Immunopharmacol. doi: 10.1016/j.intimp.2008.01.027 – volume: 561 start-page: 118 year: 2014 ident: B26 article-title: The Immune System, Bone and RANKL publication-title: Archives Biochem. Biophysics doi: 10.1016/j.abb.2014.06.003 – volume: 25 start-page: 1110 year: 2007 ident: B32 article-title: Network Pharmacology publication-title: Nat. Biotechnol. doi: 10.1038/nbt1007-1110 – volume: 32 start-page: 890 year: 2008 ident: B44 article-title: Bone Mineral Density before and after Surgical Cure of Cushing's Syndrome Due to Adrenocortical Adenoma: Prospective Study publication-title: World J. Surg. doi: 10.1007/s00268-007-9394-7 – volume: 23 start-page: 129 year: 2009 ident: B48 article-title: Stimulatory Constituents ofEclipta Prostrataon Mouse Osteoblast Differentiation publication-title: Phytother. Res. doi: 10.1002/ptr.2560 – volume: 30 start-page: 889 year: 2012 ident: B62 article-title: Icariin Promotes Bone Formation via the BMP-2/Smad4 Signal Transduction Pathway in the hFOB 1.19 Human Osteoblastic Cell Line publication-title: Int. J. Mol. Med. doi: 10.3892/ijmm.2012.1079 – volume: 11 start-page: 1541 year: 2011 ident: B14 article-title: Honokiol Isolated from Magnolia Officinalis Stimulates Osteoblast Function and Inhibits the Release of Bone-Resorbing Mediators publication-title: Int. Immunopharmacol. doi: 10.1016/j.intimp.2011.05.011 – volume: 1 start-page: 205 year: 2018 ident: B5 article-title: Bone Injury, Healing and Grafting publication-title: Basic Orthop. Sci. doi: 10.1201/9781315117294-14 – volume: 23 start-page: 1152 year: 2016 ident: B117 article-title: Bone Mass Improved Effect of Icariin for Postmenopausal Osteoporosis in Ovariectomy-Induced Rats: a Meta-Analysis and Systematic Review publication-title: Menopause doi: 10.1097/gme.0000000000000673 – volume: 61 start-page: 334 year: 2008 ident: B129 article-title: Effects of a Traditional Chinese Herbal Preparation on Osteoblasts and Osteoclasts publication-title: Maturitas doi: 10.1016/j.maturitas.2008.09.023 – volume: 157 start-page: 206 year: 2014 ident: B70 article-title: Inhibitory Effect of Ecliptae Herba Extract and its Component Wedelolactone on Pre-osteoclastic Proliferation and Differentiation publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2014.09.033 – volume: 74 start-page: 18 year: 2015 ident: B35 article-title: Ophiopogonin D: a New Herbal Agent against Osteoporosis publication-title: Bone doi: 10.1016/j.bone.2015.01.002 – volume: 17 start-page: 513 year: 2002 ident: B13 article-title: Differential Temporal Expression of Members of the Transforming Growth Factor β Superfamily during Murine Fracture Healing publication-title: J. Bone Min. Res. doi: 10.1359/jbmr.2002.17.3.513 – volume: 24 start-page: 77 year: 1996 ident: B74 article-title: Stimulative Effects of Gusuibu (Drynaria Baronii) Injection on Chick Embryo Bone Primordium Calcification In Vitro publication-title: Am. J. Chin. Med. doi: 10.1142/s0192415x96000104 – start-page: 469 volume-title: The English-Chinese Encyclopedia of Practical Traditional Chinese Medicine: Orthopedics and Traumatology year: 1991 ident: B118 – volume: 98 start-page: 59 year: 2014 ident: B46 article-title: Kirenol Stimulates Osteoblast Differentiation through Activation of the BMP and Wnt/β-Catenin Signaling Pathways in MC3T3-E1 Cells publication-title: Fitoterapia doi: 10.1016/j.fitote.2014.07.013 – volume-title: Seminars in Cell & Developmental Biology year: 2008 ident: B84 article-title: Anti-resorptive Therapies for Osteoporosis doi: 10.1016/j.semcdb.2008.08.002 – volume: 15 start-page: 558 year: 2008 ident: B133 article-title: Fructus Ligustri Lucidi Extract Improves Calcium Balance and Modulates the Calciotropic Hormone Level and Vitamin D-dependent Gene Expression in Aged Ovariectomized Rats publication-title: Menopause doi: 10.1097/gme.0b013e31814fad27 – volume: 27 start-page: 221 year: 2002 ident: B41 article-title: Effects of Epimedium Total Flavonoids Phytosomes on Preventing and Treating Bone-Loss of Ovariectomized Rats publication-title: Zhongguo Zhong Yao Za Zhi – volume: 11 start-page: 712 year: 2011 ident: B52 article-title: Costunolide Stimulates the Function of Osteoblastic MC3T3-E1 Cells publication-title: Int. Immunopharmacol. doi: 10.1016/j.intimp.2011.01.018 – volume: 10 start-page: 782 year: 2013 ident: B89 article-title: A Novel Semisynthetic Molecule Icaritin Stimulates Osteogenic Differentiation and Inhibits Adipogenesis of Mesenchymal Stem Cells publication-title: Int. J. Med. Sci. doi: 10.7150/ijms.6084 – volume: 16 start-page: 874 year: 2009 ident: B42 article-title: Antiosteoporotic Activity of Phenolic Compounds from Curculigo Orchioides publication-title: Phytomedicine doi: 10.1016/j.phymed.2009.01.005 – volume: 12 start-page: 772 year: 2003 ident: B29 article-title: Pharmacological and Clinical Research Progression of Privet Berry and its Active Ingredient publication-title: Mod. J. Integr. Chin. Traditional West. Med. – volume: 56 start-page: 1655 year: 2011 ident: B12 article-title: Osteogenic Effect of Drynariae Rhizoma Extracts and Naringin on MC3T3-E1 Cells and an Induced Rat Alveolar Bone Resorption Model publication-title: Archives Oral Biol. doi: 10.1016/j.archoralbio.2011.06.008 – volume: 316 start-page: 722 year: 2016 ident: B76 article-title: Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women with Osteoporosis publication-title: Jama doi: 10.1001/jama.2016.11136 – start-page: 2359 volume-title: Osteop. Int. year: 2014 ident: B21 article-title: Clinician’s guide to prevention and treatment of osteoporosis – volume: 18 start-page: 985 year: 2011 ident: B55 article-title: Comparison of Neoeriocitrin and Naringin on Proliferation and Osteogenic Differentiation in MC3T3-E1 publication-title: Phytomedicine doi: 10.1016/j.phymed.2011.03.002 – volume: 62 start-page: 499 year: 2013 ident: B10 article-title: Salidroside Stimulates Osteoblast Differentiation through BMP Signaling Pathway publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2013.09.019 – start-page: 427 volume-title: Nutrition and Diet in Menopause year: 2013 ident: B111 article-title: Flavonoids of Herba Epimedii and Bone Metabolism in Experimental Ovarian Deficiency doi: 10.1007/978-1-62703-373-2_32 – volume: 18 start-page: 118 year: 2018 ident: B102 article-title: Fructus Ligustri Lucidi Modulates Estrogen Receptor Expression with No Uterotrophic Effect in Ovariectomized Rats publication-title: BMC Complement. Altern. Med. doi: 10.1186/s12906-018-2171-3 – volume: 92 start-page: 261 year: 2015 ident: B39 article-title: Diagnosis and Management of Osteoporosis publication-title: Am. Fam. Physician – volume: 12 start-page: 14 year: 2017 ident: B30 article-title: New Insights into the Tonifying Kidney-Yin Herbs and Formulas for the Treatment of Osteoporosis publication-title: Arch. Osteoporos. doi: 10.1007/s11657-016-0301-4 – volume: 66 start-page: 306 year: 2014 ident: B34 article-title: Ginsenoside-Rb2 Displays Anti-osteoporosis Effects through Reducing Oxidative Damage and Bone-Resorbing Cytokines during Osteogenesis publication-title: Bone doi: 10.1016/j.bone.2014.06.010 – start-page: 55 year: 2005 ident: B82 article-title: Phytoestrogen-rich Herb Formula "XLGB" Prevents OVX-Induced Deterioration of Musculoskeletal Tissues at the Hip in Old Rats publication-title: J. Bone Min. Metab. doi: 10.1007/BF03026324 – volume: 18 start-page: 56 year: 2017 ident: B95 article-title: Treatment for Bisphosphonate-Related Osteonecrosis of the Jaw publication-title: Evid. Based Dent. doi: 10.1038/sj.ebd.6401243 – volume: 2017 start-page: 6062707 year: 2017 ident: B91 article-title: Effect of Traditional Chinese Medicine Product, QiangGuYin, on Bone Mineral Density and Bone Turnover in Chinese Postmenopausal Osteoporosis publication-title: Evidence-Based Complementary Altern. Med. doi: 10.1155/2017/6062707 – volume: 2 start-page: 922 year: 2018 ident: B28 article-title: Osteoanabolic Agents for Osteoporosis publication-title: J. Endocr. Soc. doi: 10.1210/js.2018-00118 – start-page: 24 volume-title: Osteoporosis year: 2004 ident: B4 article-title: Definition of Osteoporosis doi: 10.1007/978-3-662-09163-0_3 – volume: 664 start-page: 54 year: 2011 ident: B123 article-title: Poncirin Promotes Osteoblast Differentiation but Inhibits Adipocyte Differentiation in Mesenchymal Stem Cells publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2011.04.047 – volume: 8 start-page: 12337 year: 2015 ident: B136 article-title: Curculigoside Regulates Proliferation, Differentiation, and Pro-inflammatory Cytokines Levels in Dexamethasone-Induced Rat Calvarial Osteoblasts publication-title: Int. J. Clin. Exp. Med. – volume: 174 start-page: 48 year: 2017 ident: B107 article-title: An O-Acetyl-Glucomannan from the Rhizomes of Curculigo Orchioides: Structural Characterization and Anti-osteoporosis Activity In Vitro publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2017.06.051 – volume: 21 start-page: 1007 year: 2014 ident: B54 article-title: Icariin Prevents Ovariectomy-Induced Bone Loss and Lowers Marrow Adipogenesis publication-title: Menopause doi: 10.1097/gme.0000000000000201 – volume: 438 start-page: 221 year: 2005 ident: B3 article-title: Path Analysis of Factors for Delayed Healing and Nonunion in 416 Operatively Treated Tibial Shaft Fractures publication-title: Clin. Orthop. Relat. Research® doi: 10.1097/01.blo.0000163836.66906.74 – volume: 79 start-page: 1243 year: 1997 ident: B2 article-title: Current Concepts Review - Limb-Lengthening, Skeletal Reconstruction, and Bone Transport with the Ilizarov Method publication-title: J. Bone & Jt. Surg. doi: 10.2106/00004623-199708000-00019 – volume: 91 start-page: 209 year: 2018 ident: B73 article-title: Observational Study of the Bisphosphonate-Related Osteonecrosis of Jaws publication-title: Med. Pharm. Rep. doi: 10.15386/cjmed-838 – volume: 21 start-page: 232 year: 2014 ident: B83 article-title: Protective Effect of Curculigo Orchioides Extract on Cyclophosphamide-Induced Neurotoxicity in Murine Model publication-title: Toxicol. Int. doi: 10.4103/0971-6580.155323 – volume: 9 start-page: 66 year: 2011 ident: B17 article-title: Bone Regeneration: Current Concepts and Future Directions publication-title: BMC Med. doi: 10.1186/1741-7015-9-66 – volume: 44 start-page: 345 year: 2009 ident: B127 article-title: A Novel Semisynthesized Small Molecule Icaritin Reduces Incidence of Steroid-Associated Osteonecrosis with Inhibition of Both Thrombosis and Lipid-Deposition in a Dose-dependent Manner publication-title: Bone doi: 10.1016/j.bone.2008.10.035 – volume: 12 start-page: 204 year: 2014 ident: B58 article-title: Effect of Morinda Officinalis Capsule on Osteoporosis in Ovariectomized Rats publication-title: Chin. J. Nat. Med. doi: 10.1016/S1875-5364(14)60034-0 – volume: 2021 start-page: 5338182 year: 2021 ident: B120 article-title: Network Pharmacology-Based Strategy and Molecular Docking to Explore the Potential Mechanism of Jintiange Capsule for Treating Osteoporosis publication-title: Evid. Based Complement. Altern. Med. doi: 10.1155/2021/5338182 – volume: 10 start-page: 1089 year: 2015 ident: B60 article-title: Effect of Serum from Postmenopausal Women with Osteoporosis Exhibiting the Kidney-Yang Deficiency Pattern on Bone Formation in an hFOB 1.19 Human Osteoblastic Cell Line publication-title: Exp. Ther. Med. doi: 10.3892/etm.2015.2616 – volume: 62 start-page: 150 year: 1996 ident: B77 article-title: Effect of Crude Fractions ofPsoralea corylifoliaSeed Extract on Bone Calcification publication-title: Planta Med. doi: 10.1055/s-2006-957839 – volume: 10 start-page: 1 year: 2007 ident: B33 article-title: Patent Protection for Chinese Herbal Medicine Product Invention in Taiwan publication-title: J. World Intellect. Prop. doi: 10.1111/j.1422-2213.2007.00311.x – volume: 23 start-page: 146 year: 2014 ident: B67 article-title: Curculigoside Improves Osteogenesis of Human Amniotic Fluid-Derived Stem Cells publication-title: Stem cells Dev. doi: 10.1089/scd.2013.0261 – volume: 99 start-page: 494 year: 2008 ident: B134 article-title: Improvement of Bone Properties and Enhancement of Mineralization by Ethanol Extract of Fructus Ligustri Lucidi publication-title: Br. J. Nutr. doi: 10.1017/s0007114507801589 – volume: 5 start-page: 172133 year: 1985 ident: B23 article-title: Stimulant Effect of Epimedium in an Injection Form on the Growth of the Chick Embryo Femur In Vitro publication-title: Zhong Xi Yi Jie He Za Zhi – volume: 32 start-page: 846 year: 2017 ident: B99 article-title: TRAF6 Mediates Suppression of Osteoclastogenesis and Prevention of Ovariectomy-Induced Bone Loss by a Novel Prenylflavonoid publication-title: J. Bone Min. Res. doi: 10.1002/jbmr.3031 – volume: 20 start-page: 83 year: 2019 ident: B85 article-title: Anabolic Therapies in Osteoporosis and Bone Regeneration publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms20010083 – start-page: S7 year: 1998 ident: B19 article-title: The Cell and Molecular Biology of Fracture Healing publication-title: Clin. Orthop. Relat. Res. doi: 10.1097/00003086-199810001-00003 – volume-title: Chinese Materia Medica: Chemistry, Pharmacology and Applications year: 1998 ident: B138 – volume: 36 start-page: S20 year: 2005 ident: B24 article-title: Bone Substitutes: an Update publication-title: Injury doi: 10.1016/j.injury.2005.07.029 – volume: 144 start-page: 382 year: 2014 ident: B114 article-title: Vanillic Acid Exerts Oestrogen-like Activities in Osteoblast-like UMR 106 Cells through MAP Kinase (MEK/ERK)-mediated ER Signaling Pathway publication-title: J. steroid Biochem. Mol. Biol. doi: 10.1016/j.jsbmb.2014.08.002 – volume: 23 start-page: 1317 year: 2012 ident: B137 article-title: The First Multicenter and Randomized Clinical Trial of Herbal Fufang for Treatment of Postmenopausal Osteoporosis publication-title: Osteoporos. Int. doi: 10.1007/s00198-011-1577-2 |
SSID | ssj0001257582 |
Score | 2.4391143 |
SecondaryResourceType | review_article |
Snippet | According to World Health Organization (WHO), osteoporosis is a systematic bone disability marked by reduced bone mass and microarchitectural degeneration of... |
SourceID | doaj pubmedcentral proquest crossref |
SourceType | Open Website Open Access Repository Aggregation Database Enrichment Source Index Database |
StartPage | 911326 |
SubjectTerms | adrenocorticotropic hormone (ACTH) Bioengineering and Biotechnology bone regeneration decoction osteoporosis traditional Chinese medicines |
SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LS8QwEA7iSQ_iE9cXETwJ1b7STY4qLougwrKCt5CnFqQVu_5_Z5ru0l704qnQpiSdmXbmy0y_IeRCM8cyxn0UqzSLkFEuUsaPo5iZ3IqEec7wB-fHp2L6kj-8stdeqy-sCQv0wEFw1wCbEp-z3MWpzrXlQiW-YBYcty4gltf49QWf1wNTYXcFwhCehjQmoDBx7XVZIy1mml4J7K5eDBxRy9c_CDKHJZI9nzPZJltdsEhvwiJ3yJqrdslmj0JwjzzM6g9Ha0_B6dgybOxRbIrtGkcfu8Q5LSt6W8Nx5t5ammkcR1Vl6TMouYYQvG7KZp_MJ_fzu2nU9UeIDIRViyjDtsGcMR-nVhmLTPQF98ifExsmAMsVmjPNrS4yo7w2zogxZjIVE164LDsg6xXMfUhooowxgBVjjS47ibUVNgXslIGwnXJsROKlrKTpuMOxhcWHBAyB4pWteCWKVwbxjsjl6pbPQJzx2-BbVMBqIHJetyfAEmRnCfIvSxiR86X6JLwjmPhQlau_G5mCR8byn5yPyHig18GMwytV-d6ybYtEAAbmR_-xxGOygU8dqg9OyPri69udQlCz0Get_f4AGOf0iw priority: 102 providerName: Directory of Open Access Journals |
Title | Role of Traditional Chinese Medicine in Bone Regeneration and Osteoporosis |
URI | https://www.proquest.com/docview/2678423748 https://pubmed.ncbi.nlm.nih.gov/PMC9194098 https://doaj.org/article/0271f454e02b4bd89a1f65d505b6114b |
Volume | 10 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9VAEB5qBakP4hWPl7KCT0JqbpPsPohYsZTCUSgt9G3Zaxs4JHpyCvrvnUlySgPFB58CyS6bzOww37e7-QbgvcWABcqYpCYvElaUS4yLdZKiK73KMErkH5yX36vj8_LkAi92YFveajJgfye143pS5-vVwe9ffz5TwH9ixkn59mO0TceKl3l-oLhwenUP7lNiqjlOlxPaH5dcCJvIfNzbvLvnHjwosM4IpOAsUQ16_jMQOj9CeSsnHT2GRxOYFF9G7z-BndA-hYe3JAafwclptwqii4KSkm_GhT_BRbNDH8Ry2lgXTSsOO7qehstBhprbCdN68YMmQUfW6fqmfw5nR9_Ovh4nU_2ExBHs2iQFlxWWiDHNvXGeleorGVlfJ3WoiOtVVqKV3laFM9G64FTNO50GVVShKF7AbktjvwSRGeccccnUckrPUuuVz4lbFSaLwQRcQLq1lXaTtjiXuFhp4hhsaT1YWrOl9WjpBXy46fJzFNb4V-NDdsBNQ9bEHm5060s9hZgmgp3FEsuQ5ra0Xip6uQo9QTxbEeuzC3i3dZ-mGOKNEdOG7rrXOWVsPh5UygXUM7_ORpw_aZurQY1bZYo4snz13z1fwx5_6ngk4Q3sbtbX4S0hnY3dH1YI9odZ_Bf0iP7n |
linkProvider | Scholars Portal |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Role+of+Traditional+Chinese+Medicine+in+Bone+Regeneration+and+Osteoporosis&rft.jtitle=Frontiers+in+bioengineering+and+biotechnology&rft.au=Peng%2C+Zhicai&rft.au=Xu%2C+Ronghua&rft.au=You%2C+Qinjian&rft.date=2022-05-31&rft.pub=Frontiers+Media+S.A&rft.eissn=2296-4185&rft.volume=10&rft_id=info:doi/10.3389%2Ffbioe.2022.911326&rft_id=info%3Apmid%2F35711635&rft.externalDocID=PMC9194098 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2296-4185&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2296-4185&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2296-4185&client=summon |