Clinical Performance of the Line Immunoassay, Digital Liquid Chip Method, and Chemiluminescent Immunoassay for Detecting Specific Antinuclear Antibodies

• Published in: Archives of pathology & laboratory medicine (1976) Vol. 148; no. 5; pp. 566 - 572
• Main Authors: Su, Zhenzhen, Wang, Li, Gao, Xuedan, Huang, Zhuochun, Hu, Jing, Yang, Bin
• Format: Journal Article
• Language: English
• Published: United States College of American Pathologists 01.05.2024
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Agreements; Antibodies; Antibodies, Antinuclear - blood; Antigens; Antinuclear antibodies; Autoantibodies; Autoimmune diseases; Autoimmune Diseases - blood; Autoimmune Diseases - diagnosis; Autoimmune Diseases - immunology; Autoimmunity; Automation; Child; Chromosomes; Clinical medicine; Diagnosis; Distribution; Evaluation; Female; Health aspects; Humans; Immunoassay; Immunoassay - methods; Immunoassay - standards; Luminescent Measurements - methods; Lupus; Male; Methods; Middle Aged; Proteins; Rheumatic diseases; Rheumatic Diseases - blood; Rheumatic Diseases - diagnosis; Rheumatic Diseases - immunology; Rheumatology; Ribonucleic acid; RNA; RNA polymerase; Sensitivity and Specificity; Standardization; Statistical analysis; Systemic lupus erythematosus; Thrombolytic drugs; Tissue polypeptide antigen; TPA; Viral antibodies; Young Adult; China

Antinuclear antibodies (ANAs) against certain antigens are useful for identifying autoimmune disorders. Although new solid phase-based immunoassays have been developed for evaluating ANAs, the conventional line immunoassay (LIA) is commonly used in clinical practice. To compare the clinical performa...