Calbindin regulates Kv4.1 trafficking and excitability in dentate granule cells via CaMKII-dependent phosphorylation

• Published in: Experimental & molecular medicine Vol. 53; no. 7; pp. 1134 - 1147
• Main Authors: Kim, Kyung-Ran, Jeong, Hyeon-Ju, Kim, Yoonsub, Lee, Seung Yeon, Kim, Yujin, Kim, Hyun-Ji, Lee, Suk-Ho, Cho, Hana, Kang, Jong-Sun, Ho, Won-Kyung
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2021; Springer Nature B.V; 생화학분자생물학회
• Subjects: 13/1; 13/109; 38/70; 631/378/1697/2603; 631/378/87; 64/60; 82/80; 82/83; 9/74; Animal models; Animals; Antioxidants; Antioxidants - pharmacology; Benzylamines - pharmacology; Biomedical and Life Sciences; Biomedicine; Ca2+/calmodulin-dependent protein kinase II; Calbindin; Calbindins - genetics; Calbindins - metabolism; Calcium - metabolism; Calcium buffering; Calcium homeostasis; Calcium signalling; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - antagonists & inhibitors; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism; Cognition; Conditioning, Psychological; Dentate gyrus; Dentate Gyrus - cytology; Dentate Gyrus - drug effects; Dentate Gyrus - metabolism; Excitability; Fear - physiology; Granule cells; Homeostasis; HT29 Cells; Humans; Localization; Male; Medical Biochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Medicine; Nervous system; Neurological diseases; Oxidative stress; Phosphorylation; Potassium channels (voltage-gated); Protein Transport; Serine; Serine - metabolism; Stem Cells; Sulfonamides - pharmacology; 생화학

Calbindin, a major Ca 2+ buffer in dentate granule cells (GCs), plays a critical role in shaping Ca 2+ signals, yet how it regulates neuronal function remains largely unknown. Here, we found that calbindin knockout (CBKO) mice exhibited dentate GC hyperexcitability and impaired pattern separation, w...