Robo2 Drives Target-Selective Peripheral Nerve Regeneration in Response to Glia-Derived Signals

• Published in: The Journal of neuroscience Vol. 42; no. 5; pp. 762 - 776
• Main Authors: Murphy, Patricia L., Isaacman-Beck, Jesse, Granato, Michael
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 02.02.2022
• Subjects: Animals; Animals, Genetically Modified; Axon guidance; Axons; Axons - chemistry; Axons - physiology; Divergence; Molecular modelling; Motor Neurons - chemistry; Motor Neurons - physiology; Nerve Regeneration - physiology; Neuroglia - chemistry; Neuroglia - physiology; Peripheral nerves; Peripheral Nerves - chemistry; Peripheral Nerves - physiology; Receptors, Immunologic - analysis; Receptors, Immunologic - genetics; Receptors, Immunologic - metabolism; Regeneration; Selectivity; Zebrafish; Zebrafish Proteins - analysis; Zebrafish Proteins - genetics; Zebrafish Proteins - metabolism; target selection; collagen 4a5; robo2; peripheral nerve regeneration; zebrafish; schwann cells

Peripheral nerves are divided into multiple branches leading to divergent synaptic targets. This poses a remarkable challenge for regenerating axons as they select their original trajectory at nerve branch-points. Despite implications for functional regeneration, the molecular mechanisms underlying...