Tongluo Yishen Decoction Ameliorates Renal Fibrosis via Regulating Mitochondrial Dysfunction Induced by Oxidative Stress in Unilateral Ureteral Obstruction Rats

• Published in: Frontiers in pharmacology Vol. 12; p. 762756
• Main Authors: Jia, Qi, Han, Lin, Zhang, Xiaoyu, Yang, Wenning, Gao, Yushan, Shen, Yifan, Li, Bing, Wang, Shuyan, Qin, Mingzhen, Lowe, Scott, Qin, Jianguo, Hao, Gaimei
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 12.10.2021
• Subjects: Chinese medicine; mitochondria; mitophagy; obstruction-induced renal fibrosis; oxidative stress; Pharmacology; tongluo yishen decoction

Tongluo Yishen (TLYS) decoction is an herb that is extensively applied for the treatment of chronic kidney disease (CKD) in traditional Chinese medicine. In this study, 37 different dominant chemical constituents of TLYS were identified. Rats with unilateral ureteral obstruction (UUO) were used as a...