Identification of a novel CCR7 gene in rainbow trout with differential expression in the context of mucosal or systemic infection

► A CCR7 orthologue has been identified in rainbow trout (Oncorhynchus mykiss). ► CCR7 is strongly transcribed in thymus and spleen T cells. ► CCR7 transcription is down-regulated in head kidney and spleen of VHSV-infected fish. ► VHSV bath infection induces significant changes in CCR7 transcription...

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Published inDevelopmental and comparative immunology Vol. 38; no. 2; pp. 302 - 311
Main Authors Ordás, M. Camino, Castro, Rosario, Dixon, Brian, Sunyer, J. Oriol, Bjork, Sarah, Bartholomew, Jerri, Korytar, Tomas, Köllner, Bernd, Cuesta, Alberto, Tafalla, Carolina
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 01.10.2012
Subjects
Animals
B-lymphocytes
bacteria
CCR7
CCR7 receptor
Ceratomyxa
Ceratomyxa shasta
chemokine CCL19
chemokine CCL21
Chemokine receptors
Chemokines
Fish Diseases - immunology
Fish Proteins - genetics
Fish Proteins - immunology
Gastrointestinal Tract - immunology
gene expression
gene expression regulation
genes
gills
hindgut
intestinal mucosa
kidneys
Leukocytes - immunology
lymph nodes
Lymphocytes
mammals
messenger RNA
Mucosal immunity
Mucous Membrane - immunology
Myxozoa
Novirhabdovirus
Oncorhynchus mykiss
Oncorhynchus mykiss - genetics
Oncorhynchus mykiss - immunology
Organ Specificity
Parasitic Diseases, Animal - immunology
Phylogeny
population
Rainbow trout
Receptors, CCR7 - genetics
Receptors, CCR7 - immunology
Rhabdoviridae Infections - immunology
Rhabdoviridae Infections - veterinary
spleen
T-lymphocytes
thymus gland
Transcriptome
Viral hemorrhagic septicemia virus
viruses
CCR7
Mucosal immunity
Lymphocytes
Chemokines
Chemokine receptors
Rainbow trout
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Abstract ► A CCR7 orthologue has been identified in rainbow trout (Oncorhynchus mykiss). ► CCR7 is strongly transcribed in thymus and spleen T cells. ► CCR7 transcription is down-regulated in head kidney and spleen of VHSV-infected fish. ► VHSV bath infection induces significant changes in CCR7 transcription in the gills. ► CCR7 is up-regulated in B cells recruited to the gut in response to Ceratomyxa shasta. In mammals, CCR7 is the chemokine receptor for the CCL19 and CCL21 chemokines, molecules with a major role in the recruitment of lymphocytes to lymph nodes and Peyer’s patches in the intestinal mucosa, especially naïve T lymphocytes. In the current work, we have identified a CCR7 orthologue in rainbow trout (Oncorhynchus mykiss) that shares many of the conserved features of mammalian CCR7. The receptor is constitutively transcribed in the gills, hindgut, spleen, thymus and gonad. When leukocyte populations were isolated, IgM+ cells, T cells and myeloid cells from head kidney transcribed the CCR7 gene. In blood, both IgM+ and IgT+ B cells and myeloid cells but not T lymphocytes were transcribing CCR7, whereas in the spleen, CCR7 mRNA expression was strongly detected in T lymphocytes. In response to infection with viral hemorrhagic septicemia virus (VHSV), CCR7 transcription was down-regulated in spleen and head kidney upon intraperitoneal infection, whereas upon bath infection, CCR7 was up-regulated in gills but remained undetected in the fin bases, the main site of virus entry. Concerning its regulation in the intestinal mucosa, the ex vivo stimulation of hindgut segments with Poly I:C or inactivated bacteria significantly increased CCR7 transcription, while in the context of an infection with Ceratomyxa shasta, the levels of transcription of CCR7 in both IgM+ and IgT+ cells from the gut were dramatically increased. All these data suggest that CCR7 plays an important role in lymphocyte trafficking during rainbow trout infections, in which CCR7 appears to be implicated in the recruitment of B lymphocytes into the gut.
AbstractList ► A CCR7 orthologue has been identified in rainbow trout (Oncorhynchus mykiss). ► CCR7 is strongly transcribed in thymus and spleen T cells. ► CCR7 transcription is down-regulated in head kidney and spleen of VHSV-infected fish. ► VHSV bath infection induces significant changes in CCR7 transcription in the gills. ► CCR7 is up-regulated in B cells recruited to the gut in response to Ceratomyxa shasta. In mammals, CCR7 is the chemokine receptor for the CCL19 and CCL21 chemokines, molecules with a major role in the recruitment of lymphocytes to lymph nodes and Peyer’s patches in the intestinal mucosa, especially naïve T lymphocytes. In the current work, we have identified a CCR7 orthologue in rainbow trout (Oncorhynchus mykiss) that shares many of the conserved features of mammalian CCR7. The receptor is constitutively transcribed in the gills, hindgut, spleen, thymus and gonad. When leukocyte populations were isolated, IgM+ cells, T cells and myeloid cells from head kidney transcribed the CCR7 gene. In blood, both IgM+ and IgT+ B cells and myeloid cells but not T lymphocytes were transcribing CCR7, whereas in the spleen, CCR7 mRNA expression was strongly detected in T lymphocytes. In response to infection with viral hemorrhagic septicemia virus (VHSV), CCR7 transcription was down-regulated in spleen and head kidney upon intraperitoneal infection, whereas upon bath infection, CCR7 was up-regulated in gills but remained undetected in the fin bases, the main site of virus entry. Concerning its regulation in the intestinal mucosa, the ex vivo stimulation of hindgut segments with Poly I:C or inactivated bacteria significantly increased CCR7 transcription, while in the context of an infection with Ceratomyxa shasta, the levels of transcription of CCR7 in both IgM+ and IgT+ cells from the gut were dramatically increased. All these data suggest that CCR7 plays an important role in lymphocyte trafficking during rainbow trout infections, in which CCR7 appears to be implicated in the recruitment of B lymphocytes into the gut.
In mammals, CCR7 is the chemokine receptor for the CCL19 and CCL21 chemokines, molecules with a major role in the recruitment of lymphocytes to lymph nodes and Peyer’s patches in the intestinal mucosa, especially naïve T lymphocytes. In the current work, we have identified a CCR7 orthologue in rainbow trout (Oncorhynchus mykiss) that shares many of the conserved features of mammalian CCR7. The receptor is constitutively transcribed in the gills, hindgut, spleen, thymus and gonad. When leukocyte populations were isolated, IgM⁺ cells, T cells and myeloid cells from head kidney transcribed the CCR7 gene. In blood, both IgM⁺ and IgT⁺ B cells and myeloid cells but not T lymphocytes were transcribing CCR7, whereas in the spleen, CCR7 mRNA expression was strongly detected in T lymphocytes. In response to infection with viral hemorrhagic septicemia virus (VHSV), CCR7 transcription was down-regulated in spleen and head kidney upon intraperitoneal infection, whereas upon bath infection, CCR7 was up-regulated in gills but remained undetected in the fin bases, the main site of virus entry. Concerning its regulation in the intestinal mucosa, the ex vivo stimulation of hindgut segments with Poly I:C or inactivated bacteria significantly increased CCR7 transcription, while in the context of an infection with Ceratomyxa shasta, the levels of transcription of CCR7 in both IgM⁺ and IgT⁺ cells from the gut were dramatically increased. All these data suggest that CCR7 plays an important role in lymphocyte trafficking during rainbow trout infections, in which CCR7 appears to be implicated in the recruitment of B lymphocytes into the gut.
In mammals, CCR7 is the chemokine receptor for the CCL19 and CCL21 chemokines, molecules with a major role in the recruitment of lymphocytes to lymph nodes and Peyer's patches in the intestinal mucosa, especially naïve T lymphocytes. In the current work, we have identified a CCR7 orthologue in rainbow trout ( Oncorhynchus mykiss ) that shares many of the conserved features of mammalian CCR7. The receptor is constitutively transcribed in the gills, hindgut, spleen, thymus and gonad. When leukocyte populations were isolated, IgM + cells, T cells and myeloid cells from head kidney transcribed the CCR7 gene. In blood, both IgM + and IgT + B cells and myeloid cells but not T lymphocytes were transcribing CCR7, whereas in the spleen, CCR7 mRNA expression was strongly detected in T lymphocytes. In response to infection with viral hemorrhagic septicemia virus (VHSV), CCR7 transcription was down-regulated in spleen and head kidney upon intraperitoneal infection, whereas upon bath infection, CCR7 was up-regulated in gills but remained undetected in the fin bases, the main site of virus entry. Concerning its regulation in the intestinal mucosa, the ex vivo stimulation of hindgut segments with Poly I:C or inactivated bacteria significantly increased CCR7 transcription, while in the context of an infection with Ceratomyxa shasta , the levels of transcription of CCR7 in both IgM + and IgT + cells from the gut were dramatically increased. All these data suggest that CCR7 plays an important role in lymphocyte trafficking during rainbow trout infections, in which CCR7 appears to be implicated in the recruitment of B lymphocytes into the gut.
In mammals, CCR7 is the chemokine receptor for the CCL19 and CCL21 chemokines, molecules with a major role in the recruitment of lymphocytes to lymph nodes and Peyer's patches in the intestinal mucosa, especially naïve T lymphocytes. In the current work, we have identified a CCR7 orthologue in rainbow trout (Oncorhynchus mykiss) that shares many of the conserved features of mammalian CCR7. The receptor is constitutively transcribed in the gills, hindgut, spleen, thymus and gonad. When leukocyte populations were isolated, IgM(+) cells, T cells and myeloid cells from head kidney transcribed the CCR7 gene. In blood, both IgM(+) and IgT(+) B cells and myeloid cells but not T lymphocytes were transcribing CCR7, whereas in the spleen, CCR7 mRNA expression was strongly detected in T lymphocytes. In response to infection with viral hemorrhagic septicemia virus (VHSV), CCR7 transcription was down-regulated in spleen and head kidney upon intraperitoneal infection, whereas upon bath infection, CCR7 was up-regulated in gills but remained undetected in the fin bases, the main site of virus entry. Concerning its regulation in the intestinal mucosa, the ex vivo stimulation of hindgut segments with Poly I:C or inactivated bacteria significantly increased CCR7 transcription, while in the context of an infection with Ceratomyxa shasta, the levels of transcription of CCR7 in both IgM(+) and IgT(+) cells from the gut were dramatically increased. All these data suggest that CCR7 plays an important role in lymphocyte trafficking during rainbow trout infections, in which CCR7 appears to be implicated in the recruitment of B lymphocytes into the gut.
In mammals, CCR7 is the chemokine receptor for the CCL19 and CCL21 chemokines, molecules with a major role in the recruitment of lymphocytes to lymph nodes and Peyer's patches in the intestinal mucosa, especially naieve T lymphocytes. In the current work, we have identified a CCR7 orthologue in rainbow trout (Oncorhynchus mykiss) that shares many of the conserved features of mammalian CCR7. The receptor is constitutively transcribed in the gills, hindgut, spleen, thymus and gonad. When leukocyte populations were isolated, IgM+ cells, T cells and myeloid cells from head kidney transcribed the CCR7 gene. In blood, both IgM+ and IgT+ B cells and myeloid cells but not T lymphocytes were transcribing CCR7, whereas in the spleen, CCR7 mRNA expression was strongly detected in T lymphocytes. In response to infection with viral hemorrhagic septicemia virus (VHSV), CCR7 transcription was down-regulated in spleen and head kidney upon intraperitoneal infection, whereas upon bath infection, CCR7 was up-regulated in gills but remained undetected in the fin bases, the main site of virus entry. Concerning its regulation in the intestinal mucosa, the ex vivo stimulation of hindgut segments with Poly I: C or inactivated bacteria significantly increased CCR7 transcription, while in the context of an infection with Ceratomyxa shasta, the levels of transcription of CCR7 in both IgM+ and IgT+ cells from the gut were dramatically increased. All these data suggest that CCR7 plays an important role in lymphocyte trafficking during rainbow trout infections, in which CCR7 appears to be implicated in the recruitment of B lymphocytes into the gut.
Author Sunyer, J. Oriol
Ordás, M. Camino
Köllner, Bernd
Cuesta, Alberto
Castro, Rosario
Bartholomew, Jerri
Dixon, Brian
Korytar, Tomas
Bjork, Sarah
Tafalla, Carolina
AuthorAffiliation a Centro de Investigación en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain
d Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Institute of Infectology, 17493 Greifswald-Insel Riems, Germany
e Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA
c Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
b Department of Biology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1
AuthorAffiliation_xml – name: e Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA
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Issue 2
Keywords CCR7
Mucosal immunity
Lymphocytes
Chemokines
Chemokine receptors
Rainbow trout
Language English
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Snippet ► A CCR7 orthologue has been identified in rainbow trout (Oncorhynchus mykiss). ► CCR7 is strongly transcribed in thymus and spleen T cells. ► CCR7...
In mammals, CCR7 is the chemokine receptor for the CCL19 and CCL21 chemokines, molecules with a major role in the recruitment of lymphocytes to lymph nodes and...
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SubjectTerms Animals
B-lymphocytes
bacteria
CCR7
CCR7 receptor
Ceratomyxa
Ceratomyxa shasta
chemokine CCL19
chemokine CCL21
Chemokine receptors
Chemokines
Fish Diseases - immunology
Fish Proteins - genetics
Fish Proteins - immunology
Gastrointestinal Tract - immunology
gene expression
gene expression regulation
genes
gills
hindgut
intestinal mucosa
kidneys
Leukocytes - immunology
lymph nodes
Lymphocytes
mammals
messenger RNA
Mucosal immunity
Mucous Membrane - immunology
Myxozoa
Novirhabdovirus
Oncorhynchus mykiss
Oncorhynchus mykiss - genetics
Oncorhynchus mykiss - immunology
Organ Specificity
Parasitic Diseases, Animal - immunology
Phylogeny
population
Rainbow trout
Receptors, CCR7 - genetics
Receptors, CCR7 - immunology
Rhabdoviridae Infections - immunology
Rhabdoviridae Infections - veterinary
spleen
T-lymphocytes
thymus gland
Transcriptome
Viral hemorrhagic septicemia virus
viruses
Title Identification of a novel CCR7 gene in rainbow trout with differential expression in the context of mucosal or systemic infection
URI https://dx.doi.org/10.1016/j.dci.2012.07.001
https://www.ncbi.nlm.nih.gov/pubmed/22858409
https://search.proquest.com/docview/1039884052
https://search.proquest.com/docview/1125226384
https://pubmed.ncbi.nlm.nih.gov/PMC3739294
Volume 38
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