Resilience to Pain: A Peripheral Component Identified Using Induced Pluripotent Stem Cells and Dynamic Clamp - Mis, Malgorzata A.; Yang, Yang; Tanaka, Brian S.; Gomis-Perez, Carolina; Liu, Shujun; Dib-Hajj, Fadia; Adi, Talia; Garcia-Milian, Rolando; Schulman, Betsy R.; Dib-Hajj, Sulayman D.; Waxman, Stephen G. (The Journal of neuroscience, 2019)
Keywords: Adult; Central nervous system; Child; Chronic pain; Chronic Pain - genetics; Chronic Pain - physiopathology; Dorsal root ganglia; Erythromelalgia - genetics; Erythromelalgia - physiopathology; Excitability; Excitatory Postsynaptic Potentials; Exome - genetics; Female; Ganglia, Spinal - cytology; Ganglia, Spinal - physiopathology; Humans; Immunohistochemistry; Individuality; Induced Pluripotent Stem Cells; Inhibitory postsynaptic potentials; KCNQ Potassium Channels - genetics; KCNQ Potassium Channels - metabolism; Male; Membrane Potentials; Mutation; NAV1.7 Voltage-Gated Sodium Channel - genetics; Neurons; Pain; Pain Measurement; Pain sensitivity; Patch-Clamp Techniques; Peripheral nervous system; Pluripotency; Potassium channels (voltage-gated); Resilience, Psychological; Sensitivity; Sensory neurons; Sensory Receptor Cells; Signaling; Sodium channels (voltage-gated); Stem cells; potassium channel; pain; induced pluripotent stem cells; dynamic clamp; voltage-gated sodium channel; whole exome sequencing