JAK/STAT in leukemia: a clinical update

Over the past three decades, considerable efforts have been expended on understanding the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway in leukemia, following the identification of the JAK2V617F mutation in myeloproliferative neoplasms (MPNs). The aim of...

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Published inMolecular cancer Vol. 23; no. 1; pp. 25 - 12
Main Authors Liang, Dong, Wang, Qiaoli, Zhang, Wenbiao, Tang, Hailin, Song, Cailu, Yan, Zhimin, Liang, Yang, Wang, Hua
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 26.01.2024
BioMed Central
BMC
Subjects
Antimitotic agents
Antineoplastic agents
Cell differentiation
Cell division
Cellular signal transduction
Clinical trials
Control systems
Cytokines
Development and progression
DNA methylation
Enzyme inhibitors
Genes
Humans
JAK/STAT inhibitors
JAK/STAT signaling pathway
Janus kinase
Janus Kinases - genetics
Janus Kinases - metabolism
Kinases
Leukemia
Lymphocytes
Mutation
Myeloproliferative Disorders - drug therapy
Myeloproliferative Disorders - genetics
Pathogenesis
Patient compliance
Phosphorylation
Proteins
Signal Transduction
STAT Transcription Factors - genetics
STAT Transcription Factors - metabolism
Leukemia
JAK/STAT signaling pathway
JAK/STAT inhibitors
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Abstract Over the past three decades, considerable efforts have been expended on understanding the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway in leukemia, following the identification of the JAK2V617F mutation in myeloproliferative neoplasms (MPNs). The aim of this review is to summarize the latest progress in our understanding of the involvement of the JAK/STAT signaling pathway in the development of leukemia. We also attempt to provide insights into the current use of JAK/STAT inhibitors in leukemia therapy and explore pertinent clinical trials in this field.
AbstractList Over the past three decades, considerable efforts have been expended on understanding the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway in leukemia, following the identification of the JAK2V617F mutation in myeloproliferative neoplasms (MPNs). The aim of this review is to summarize the latest progress in our understanding of the involvement of the JAK/STAT signaling pathway in the development of leukemia. We also attempt to provide insights into the current use of JAK/STAT inhibitors in leukemia therapy and explore pertinent clinical trials in this field. Keywords: JAK/STAT signaling pathway, Leukemia, JAK/STAT inhibitors
Over the past three decades, considerable efforts have been expended on understanding the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway in leukemia, following the identification of the JAK2V617F mutation in myeloproliferative neoplasms (MPNs). The aim of this review is to summarize the latest progress in our understanding of the involvement of the JAK/STAT signaling pathway in the development of leukemia. We also attempt to provide insights into the current use of JAK/STAT inhibitors in leukemia therapy and explore pertinent clinical trials in this field.
Abstract Over the past three decades, considerable efforts have been expended on understanding the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway in leukemia, following the identification of the JAK2V617F mutation in myeloproliferative neoplasms (MPNs). The aim of this review is to summarize the latest progress in our understanding of the involvement of the JAK/STAT signaling pathway in the development of leukemia. We also attempt to provide insights into the current use of JAK/STAT inhibitors in leukemia therapy and explore pertinent clinical trials in this field.
Over the past three decades, considerable efforts have been expended on understanding the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway in leukemia, following the identification of the JAK2V617F mutation in myeloproliferative neoplasms (MPNs). The aim of this review is to summarize the latest progress in our understanding of the involvement of the JAK/STAT signaling pathway in the development of leukemia. We also attempt to provide insights into the current use of JAK/STAT inhibitors in leukemia therapy and explore pertinent clinical trials in this field.Over the past three decades, considerable efforts have been expended on understanding the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway in leukemia, following the identification of the JAK2V617F mutation in myeloproliferative neoplasms (MPNs). The aim of this review is to summarize the latest progress in our understanding of the involvement of the JAK/STAT signaling pathway in the development of leukemia. We also attempt to provide insights into the current use of JAK/STAT inhibitors in leukemia therapy and explore pertinent clinical trials in this field.
ArticleNumber 25
Audience Academic
Author Tang, Hailin
Song, Cailu
Zhang, Wenbiao
Liang, Yang
Yan, Zhimin
Liang, Dong
Wang, Qiaoli
Wang, Hua
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JAK/STAT signaling pathway
JAK/STAT inhibitors
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SSID ssj0017874
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SecondaryResourceType review_article
Snippet Over the past three decades, considerable efforts have been expended on understanding the Janus kinase/signal transducer and activator of transcription...
Abstract Over the past three decades, considerable efforts have been expended on understanding the Janus kinase/signal transducer and activator of...
SourceID doaj
proquest
gale
pubmed
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SourceType Open Website
Aggregation Database
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Enrichment Source
StartPage 25
SubjectTerms Antimitotic agents
Antineoplastic agents
Cell differentiation
Cell division
Cellular signal transduction
Clinical trials
Control systems
Cytokines
Development and progression
DNA methylation
Enzyme inhibitors
Genes
Humans
JAK/STAT inhibitors
JAK/STAT signaling pathway
Janus kinase
Janus Kinases - genetics
Janus Kinases - metabolism
Kinases
Leukemia
Lymphocytes
Mutation
Myeloproliferative Disorders - drug therapy
Myeloproliferative Disorders - genetics
Pathogenesis
Patient compliance
Phosphorylation
Proteins
Signal Transduction
STAT Transcription Factors - genetics
STAT Transcription Factors - metabolism
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Title JAK/STAT in leukemia: a clinical update
URI https://www.ncbi.nlm.nih.gov/pubmed/38273387
https://www.proquest.com/docview/2925660932
https://www.proquest.com/docview/2919742175
https://doaj.org/article/073783ba1af74fbeb981ff0ef2bd4dea
Volume 23
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