Impact of menstrual cycle phase on endocrine effects of partial sleep restriction in healthy women

• Published in: Psychoneuroendocrinology Vol. 49; pp. 34 - 46
• Main Authors: LeRoux, Amanda, Wright, Lisa, Perrot, Tara, Rusak, Benjamin
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.11.2014; Elsevier
• Subjects: Adult; Affect - physiology; Behavioral psychophysiology; Biological and medical sciences; Circadian rhythm; Cortisol; Endocrinology & Metabolism; Female; Follicular Phase - metabolism; Follicular Phase - psychology; Fundamental and applied biological sciences. Psychology; Health; Hormones and behavior; Humans; Hunger; Hunger - physiology; Hydrocortisone - metabolism; Luteal Phase - metabolism; Luteal Phase - psychology; Menstrual cycle; Metabolism; Mood; Pituitary-Adrenal Function Tests; Progesterone - metabolism; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Saliva - metabolism; Sleep; Sleep Deprivation - metabolism; Sleep Deprivation - psychology; Wakefulness; Young Adult; Hunger; Sleep; Mood; Menstrual cycle; Cortisol; Circadian rhythm; Metabolism; Human; Corticosteroid; Deprivation; Healthy subject; Steroid hormone; Antiinflammatory agent; Biological rhythm; Hydrocortisone; Glucocorticoid; Partial; Adrenal hormone; Sleep wake cycle; Woman
• ISSN: 0306-4530; 1873-3360; 1873-3360
• DOI: 10.1016/j.psyneuen.2014.06.002

There is extensive evidence that sleep restriction alters endocrine function in healthy young men, increasing afternoon cortisol levels and modifying levels of other hormones that regulate metabolism. Recent studies have confirmed these effects in young women, but have not investigated whether menstrual cycle phase influences these responses. The effects on cortisol levels of limiting sleep to 3h for one night were assessed in two groups of women at different points in their menstrual cycles: mid-follicular and mid-luteal. Eighteen healthy, young women, not taking oral contraceptives (age: 21.8±0.53; BMI: 22.5±0.58 [mean±SEM]), were studied. Baseline sleep durations, eating habits and menstrual cycles were monitored. Salivary samples were collected at six times of day (08:00, 08:30, 11:00, 14:00, 17:00, 20:00) during two consecutive days: first after a 10h overnight sleep opportunity (Baseline) and then after a night with a 3h sleep opportunity (Post-sleep restriction). All were awakened at the same time of day. Women in the follicular phase showed a significant decrease (p=0.004) in their cortisol awakening responses (CAR) after sleep restriction and a sustained elevation in afternoon/evening cortisol levels (p=0.008), as has been reported for men. Women in the luteal phase showed neither a depressed CAR, nor an increase in afternoon/evening cortisol levels. Secondary analyses examined the impact of sleep restriction on self-reported hunger and mood. Menstrual cycle phase dramatically altered the cortisol responses of healthy, young women to a single night of sleep restriction, implicating effects of spontaneous changes in endocrine status on adrenal responses to sleep loss.