LRRK2 modifies α-syn pathology and spread in mouse models and human neurons - Bieri, Gregor; Brahic, Michel; Bousset, Luc; Couthouis, Julien; Kramer, Nicholas J.; Ma, Rosanna; Nakayama, Lisa; Monbureau, Marie; Defensor, Erwin; Schüle, Birgitt; Shamloo, Mehrdad; Melki, Ronald; et al. (Acta neuropathologica, 2019)
Keywords: alpha-Synuclein - metabolism; Amyloid - metabolism; Animal models; Animals; Basal ganglia; Biochemistry, Molecular Biology; Brain diseases; Cells, Cultured; Cellular Biology; Central nervous system diseases; Cerebral Cortex - cytology; Clinical trials; Dopamine receptors; Exploratory Behavior; Genetic screening; Glucosylceramidase - genetics; Hippocampus - cytology; Humans; Induced Pluripotent Stem Cells - cytology; Inflammation; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - antagonists & inhibitors; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - deficiency; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - genetics; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - physiology; Life Sciences; LRRK2 protein; Medicine; Medicine & Public Health; Mice; Mice, Inbred C57BL; Mice, Transgenic; Movement disorders; Mutation; Mutation, Missense; Neurodegeneration; Neurodegenerative diseases; Neurons; Neurons - metabolism; Neurons - pathology; Neurons and Cognition; Neurosciences; Original Paper; Parkinson Disease - genetics; Parkinson Disease - pathology; Parkinson's disease; Pars Compacta - pathology; Pathology; Pluripotency; Primary Cell Culture; Protein Aggregation, Pathological - etiology; Protein Aggregation, Pathological - genetics; Protein Aggregation, Pathological - pathology; Recombinant Proteins - metabolism; Risk factors; RNA Interference; Rotarod Performance Test; Stem cells; Substantia nigra; Synuclein; Therapeutic applications; Transgenic mice; Aggregation; Genetic interaction; LRRK2; Parkinson’s disease; Alpha-synuclein; GBA