Efficacy of favipiravir against influenza virus resistant to both baloxavir and neuraminidase inhibitors

• Published in: Journal of Antimicrobial Chemotherapy Vol. 78; no. 7; pp. 1649 - 1657
• Main Authors: Kiso, Maki, Yamayoshi, Seiya, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: US Oxford University Press (OUP) 20.05.2023; Oxford University Press
• Subjects: Animals; Antiviral Agents; Antiviral Agents - pharmacology; Drug Resistance, Viral; Drug Resistance, Viral - genetics; Editor's Choice; Enzyme Inhibitors; Enzyme Inhibitors - pharmacology; Guanidines; Guanidines - pharmacology; Humans; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H1N1 Subtype - genetics; Influenza, Human; Influenza, Human - drug therapy; Mice; Neuraminidase; Neuraminidase - genetics; Original Research; Oseltamivir; Oseltamivir - pharmacology; Pyridones; Pyridones - pharmacology; Triazines; Triazines - pharmacology

Abstract Objectives Widespread resistance of influenza viruses to neuraminidase (NA) inhibitor or polymerase inhibitor, baloxavir, is a major public health concern. The amino acid mutations R152K in NA and I38T in polymerase acidic (PA) are responsible for resistance to NA inhibitors and baloxavir,...