Defining the risk of SARS-CoV-2 variants on immune protection

• Published in: Nature (London) Vol. 605; no. 7911; pp. 640 - 652
• Main Authors: Ghedin, Elodie, Krammer, Florian, Grifoni, Alba, Alter, Galit, Baric, Ralph S., Barouch, Dan H., Bloyet, Louis-Marie, Bonenfant, Gaston, Boon, Adrianus C. M., Boritz, Eli A., Bratt, Debbie L., Bricker, Traci L., Brown, Liliana, Buchser, William J., Carreño, Juan Manuel, Darling, Tamarand L., Di, Han, Dittmann, Meike, Doria-Rose, Nicole A., Douek, Daniel C., Drosten, Christian, Edara, Venkata-Viswanadh, Ellebedy, Ali, Fabrizio, Thomas P., Ferrari, Guido, Fischer, Will M., Florence, William C., Franks, John, García-Sastre, Adolfo, Godzik, Adam, Gonzalez-Reiche, Ana Silvia, Gordon, Aubree, Haagmans, Bart L., Halfmann, Peter J., Holbrook, Michael R., James, Sarah L., Jaroszewski, Lukasz, Johnson, Robert M., Jones, Terry C., Kawaoka, Yoshihiro, Kercher, Lisa, Koopmans, Marion P. G., Korber, Bette, Koren, Eilay, LeGresley, Eric B., Liu, Zhuoming, Livingston, Brandi, Logue, James P., Luo, Yang, McDermott, Adrian B., McElrath, Margaret J., Menachery, Vineet D., Mühlemann, Barbara, Munt, Jenny E., Nair, Manoj S., Netzl, Antonia, O’Dell, Sijy, Pekosz, Andrew, Perlman, Stanley, Pontelli, Marjorie C., Rothlauf, Paul W., Sacharen, Sinai, Scheuermann, Richard H., Schmidt, Stephen D., Schotsaert, Michael, Schultz-Cherry, Stacey, Seder, Robert A., Sedova, Mayya, Shabman, Reed S., Shen, Xiaoying, Shi, Pei-Yong, Shukla, Maulik, Simon, Viviana, Stumpf, Spencer, Thackray, Larissa B., Theiler, James, Thomas, Paul G., Trifkovic, Sanja, Turner, Samuel A., Vakaki, Maria A., van Bakel, Harm, VanBlargan, Laura A., Vincent, Leah R., Wallace, Zachary S., Wang, Li, Wang, Maple, Wang, Pengfei, Wang, Wei, Webby, Richard J., Wentworth, David E., Whelan, Sean P. J., Whitener, Bradley M., Wilks, Samuel H., Xie, Xuping, Ying, Baoling, Zhou, Bin, Hertz, Tomer, Smith, Derek J., Diamond, Michael S., Suthar, Mehul S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.05.2022; Nature Publishing Group
• Subjects: 631/250/590; 692/699/255/2514; Allergies; Animal models; Animals; Antiviral drugs; Bioinformatics; Biological Evolution; Collaboration; Coronaviruses; COVID-19; COVID-19 Vaccines; Disease transmission; Evolution; Evolution & development; Genomes; Health risks; Human populations; Humanities and Social Sciences; Humans; Immunity; Infections; Infectious diseases; Life Sciences; Microbiology and Parasitology; multidisciplinary; Mutation; National Institute of Allergy and Infectious Diseases (U.S.); Pandemics; Pandemics - prevention & control; Peer review; Perspective; Pharmacogenomic Variants; Proteins; Public health; R&D; Reagents; Research & development; Respiratory diseases; Risk assessment; Risk communication; SARS-CoV-2 - genetics; SARS-CoV-2 - pathogenicity; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Teams; United States - epidemiology; Vaccines; Viral diseases; Virology; Virulence; Viruses; United States; United States > US; Variants of concern; SARS-CoV-2

The global emergence of many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants jeopardizes the protective antiviral immunity induced after infection or vaccination. To address the public health threat caused by the increasing SARS-CoV-2 genomic diversity, the National Institute o...