Interplay of mechanical and binding properties of Fibronectin type I

• Published in: Theoretical chemistry accounts Vol. 125; no. 3-6; pp. 397 - 405
• Main Authors: Diao, Jiankuai, Maniotis, Andrew J., Folberg, Robert, Tajkhorshid, Emad
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.03.2010
• Subjects: Atomic/Molecular Structure and Spectra; Chemistry; Chemistry and Materials Science; Inorganic Chemistry; Organic Chemistry; Physical Chemistry; Regular Article; Theoretical and Computational Chemistry; Molecular dynamics; Extracellular matrix; Mechanical proteins; Fibronectin binding protein; Steered molecular dynamics

Fibronectins (FNs) are a major component of the extracellular matrix (ECM), and provide important binding sites for a variety of ligands outside and on the surface of the cell. Similar to other ECM proteins, FNs are consistently subject to mechanical stress in the ECM. Therefore, it is important to...