Monocyte Chemotactic Protein-induced Protein 1 (MCPIP1) Suppresses Stress Granule Formation and Determines Apoptosis under Stress

• Published in: The Journal of biological chemistry Vol. 286; no. 48; pp. 41692 - 41700
• Main Authors: Qi, Dongfei, Huang, Shengping, Miao, Ruidong, She, Zhi-Gang, Quinn, Tim, Chang, Yingzi, Liu, Jianguo, Fan, Daping, Chen, Y. Eugene, Fu, Mingui
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.12.2011; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Apoptosis; Apoptosis - physiology; Cell Biology; GW Body; HEK293 Cells; HeLa Cells; Homeostasis - physiology; Humans; Macrophages; Macrophages - immunology; Macrophages - metabolism; MCPIP1; Mice; Mice, Knockout; Mutagenesis; Ribonucleases - genetics; Ribonucleases - immunology; Ribonucleases - metabolism; Signal Transduction; Stress Granule; Stress, Physiological - physiology; Transcription Factors - genetics; Transcription Factors - immunology; Transcription Factors - metabolism; GW Body; Signal Transduction; Stress Granule; MCPIP1; Macrophages; Apoptosis; Cell Biology
• ISSN: 0021-9258; 1083-351X; 1083-351X
• DOI: 10.1074/jbc.M111.276006

It is unclear how stress granule (SG) formation and cellular apoptosis are coordinately regulated. MCPIP1 (monocyte chemotactic protein-induced protein 1), also known as Zc3h12a, is a critical regulator of the inflammatory response and immune homeostasis. However, the role of MCPIP1 in stress respon...