Evidence for the Presence of Borrelia burgdorferi Biofilm in Infected Mouse Heart Tissues

• Published in: Microorganisms (Basel) Vol. 12; no. 9; p. 1766
• Main Authors: Thippani, Sahaja, Patel, Niraj Jatin, Jathan, Jasmine, Filush, Kate, Socarras, Kayla M., DiLorenzo, Jessica, Balasubramanian, Kunthavai, Gupta, Khusali, Ortiz Aleman, Geneve, Pandya, Jay M., Kavitapu, Venkata V., Zeng, Daina, Miller, Jennifer C., Sapi, Eva
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.08.2024; MDPI
• Subjects: Alginates; Alginic acid; Animal tissues; Antibiotics; Atomic force microscopy; Bacteria; biofilm; Biofilms; Borrelia burgdorferi; C-reactive protein; Carditis; Chronic illnesses; Drinking water; Drug resistance; Ethanol; Ethylenediaminetetraacetic acid; fish; fluorescence; Fluorescence in situ hybridization; Heart; Heart diseases; hybridization; Immunohistochemistry; Infections; Inflammation; Laboratory animals; Lyme disease; mice; Microscopy; myocarditis; Spirochetes; Vector-borne diseases; Massachusetts; St Louis Missouri; United States > US; C-reactive protein; immunohistochemistry; atomic force microscopy; inflammation; carditis; biofilm

Borrelia burgdorferi, the bacterium responsible for Lyme disease, has been shown to form antimicrobial-tolerant biofilms, which protect it from unfavorable conditions. Bacterial biofilms are known to significantly contribute to severe inflammation, such as carditis, a common manifestation of Lyme di...